Aim. To assess the risks of all-cause and cardiovascular mortality in smokers with hypertension (HTN) based on the results of a 34-year prospective observation of a Tomsk population. Material and methods. The study included 630 men and 916 women aged 2059 years who underwent primary screening in 1988-1991. HTN was established with blood pressure (BP) ³140/90 mm Hg and <140/90 mm Hg in persons taking antihypertensive drugs. People who smoked ³1 cigarette per day or stopped smoking less than a year ago were classified as smokers, and those who stopped smoking for more than one year were classified as non-smokers. Over 34-year observation, 535 deaths were identified, of which 232 were from cardiovascular causes. Results. The combination of hypertension and smoking increases the relative risk (RR) of all-cause death by 3,4 times in the general population, by 2,6 times among men and by 3,4 times among women. The risk of cardiovascular death also increases (RR 3,6). This effect was most pronounced among people in the younger age group (RR 8,5). Hypertensive smokers had a 1,5 times higher risk of premature all-cause death compared with nonsmokers with hypertension. Multivariate analysis found that smoking, regardless of other predictors, increases the all-cause and cardiovascular death risk by 2,61 and 2,77 times, respectively. HTN increases allcause and cardiovascular death risk by 1,32 and 1,52 times, respectively. Conclusion. Hypertension and smoking are among the most influential modifiable risk factors for premature death, and their combination increases the RR of allcause and cardiovascular death by 3,4 and 3,6 times, respectively. A more unfavorable prognosis has been established for women and young people. When HTN and smoking are combined, the 34-year survival prognosis decreases to 30,8% compared to 79,3% in individuals without these risk factors.

New coronavirus disease (COVID-19) caused by SARS-CoV-2 is associated with a high mortality rate and is a major public health problem worldwide. In publications from the early months of the COVID-19 pandemic, the authors reported that hypertension (HTN) is associated with higher susceptibility to SARS-CoV-2 infection, severe disease, and increased mortality associated with COVID-19. The risk of more severe clinical manifestations of COVID-19 is higher in men and increases dramatically with age. However, according to the results of multivariate analyses with the inclusion of data on age, risk factors (RF) of cardiovascular diseases (CVD), diabetes mellitus, the independent role of HTN in the development and outcome of COVID-19 was not confirmed, while age turned out to be the most significant factor. The authors made the conclusion that HTN may not play an independent role in SARS-CoV-2 infection and the course of COVID-19, and the formation of adverse outcomes is influenced by old age. However, age-related changes include accumulated chronic diseases, their RF, target organ damage etc. Morphofunctional changes caused by a long course of HTN, the development of associated clinical conditions can increase the susceptibility of the cardiovascular system to the damaging effects of SARS-CoV-2, as well as contribute to the formation of adverse outcomes of COVID-19. In addition, diabetes mellitus, obesity, and other metabolic disorders associated with HTN negatively contribute to the course of COVID-19 and the risk of mortality. A more severe course of COVID-19 in HTN patients, especially the elderly, may be facilitated by the mechanisms of cellular and immune inflammation common in these diseases. The endothelial monolayer plays an important role. Endothelial injury and endothelial dysfunction in HTN and endothelitis in COVID-19 may reinforce each other, increasing the likelihood of cardiovascular events in patients with COVID-19. An important pathogenetic mechanism of HTN — the renin-angiotensin- aldosterone system (RAAS) activation — plays a significant role in the genesis of COVID-19. Angiotensin-converting enzyme 2 (ACE) is a key receptor for SARS-CoV-2 entry into human cells, providing a link between COVID-19 and RAAS. In this regard, it was expected that ACE inhibitors and angiotensin II receptor blockers (ARB), which modulate the RAAS, may increase the risk of SARS-CoV-2 infection and worsen outcomes in COVID-19. However, in further experimental and clinical studies, these assumptions were not confirmed. Moreover, currently international experts strongly recommend that ACE inhibitors or ARB be continued in HTN patients with COVID-19, as they protect against cardiovascular complications and improve prognosis. Observations have shown that COVID-19 significantly increases the likelihood of developing HTN, acute coronary syndrome, cardiac arrhythmias, right ventricular dysfunction, myocardial fibrosis, heart failure, and also increases the risk of death from CVD. Further clinical and long-term prospective studies are needed to evaluate the role of past COVID-19 as a RF for CVD and mortality.

Cardiac metastasis from endometrial cancer is a very rare finding. The article presents a case of death, demonstrating the aggressive clinical course of endometrial serous carcinoma. In this clinical example the disease was accompanied by generalized metastasizing through a lymphogenous route to unexpected distant organs (peribronchial lymph nodes, pleura, pericardium).

Aim. To study the prognostic significance of cardiovascular risk factors (RFs) in the formation of all-cause and cardiovascular mortality based on the results of a 27-year prospective cohort study of Tomsk population of both sexes aged 20-59 years.Material and methods. The object of study was random house-to-house sample of Tomsk population. In total, 1546 people (630 men and 916 women) aged 20-59 were examined. In 1988-1991, the prevalence of following cardiovascular RFs was studied: hypertension (HTN), overweight, smoking, alcohol consumption, hypercholesterolemia (HCE), low high-density lipoprotein cholesterol levels (hypo-HDL-emia), hypertriglyceridemia (HTG). All examination methods used were strictly standardized. To determine the RF, the criteria generally accepted in epidemiological studies were used. Over 27 years of follow-up, 330 deaths were recorded, including 142 due to cardiovascular disease.Results. In the multivariate Cox proportional hazard model, the following va­riables were studied: HTN, overweight, smoking, alcohol consumption, HCE, hypo-HDL-emia, HTG, coronary artery disease (CAD) (according to epi­demio­logical criteria), and age. The strongest predictor of of all-cause death was frequent alcohol use (relative risk (RR) 2,75). Smoking increased the risk of death by 2,72 times. Among former smokers, the risk of all-cause death was 1,9 times higher compared to non-smokers. HTN increases the death risk by 1,61 times. Each year of life lived increases the death risk by 1,06 times. The most significant risk factor for death from CVD was frequent alcohol consumption (RR 3,01). Smoking increases the cardiovascular death risk by 2,28 times. Among former smokers, the RR of cardiovascular death was 1,91. HTN increases the risk of cardiovascular mortality by 1,84 times compared with people with normal blood pressure. Each year of life lived increases the risk of cardiovascular death by 1,1 times. In multivariate analysis, overweight, HCE, hypo-HDL-emia, HTG did not have a significant independent effect on the all-cause and cardiovascular death risk.Conclusion. In a 27-year cohort prospective study, independent predictors of all-cause and cardiovascular mortality, along with hypertension and age, were lifestyle risk factors, such as smoking and frequent alcohol consumption.

Aim . To study the effect of hypertension (HTN) on the risk of cardio­vascular and all-cause death among men and women aged 20-59 years among Tomsk population in a 34-year cohort prospective study. Material and methods . The study was carried out on the model of Tomsk population. At stage I (1988-1991), 1546 people (630 men and 916 women) aged 20-59 years were examined, the prevalence of hypertension among which was studied. At stage II (2022), the effect of HTN on and all-cause death risk was analyzed. Results . A significant effect of HTN on mortality was revealed: the relative risk (RR) of all-cause and cardiovascular death was 1,9 (p<0,001) and 2,7 (p<0,001), respectively. Among men, HTN increased the risk of all-cause death by 1,4 times (p<0,001); among women — 2,5 times (p<0,001). The RR of cardiovascular death among men with HTN was 1,5 (p<0,05); among women with hypertension — 5,2 (p<0,001). The RR of non-cardiovascular death in HTN persons was 1,4 (p<0,01). Mean blood pressure at primary screening were higher in non-survivors compared to survivors. This pattern was observed in all sex and age groups. Among persons with initially normal blood pressure, the 34-year survival rate was 70,9%, while with increased blood pressure — 45,1%. Conclusion . The results of a 34-year cohort prospective study confirm the significant impact of HTN on the death risk and survival prognosis.

Neuropilin is of wide scientific and practical interest in the development of pathological conditions in both adult and pediatric patients. Modern scientific researches expand the role of this protein in various systems of the child's body both intrauterine and after birth. The results of recent studies related to the role of neuropilin, its effects and relationship with the development of various chronic diseases are considered in this bibliographical review of PubMed, ClinicalKey covering 2018-2023 with the purpose of expanding the understanding of neuropilin as a protein involved in the intranatal development of the fetus and metabolic processes in the extrauterine period. Further studies of neuropilin would clarify its role in the development of chronic noninfectious diseases and therapeutic approaches in pediatric practice.

Масса тела (МТ) в течение взрослого периода жизни нестабильна и может изменяться в связи с рядом заболеваний, влияющих на жировую и нежировую составляющие МТ. Поэтому при прогнозировании вероятности развития заболеваний, ассоциированных с ожирением, и оценке риска смертности важно учитывать не только текущий показатель, но и направленность динамики МТ. ЦЕЛЬ ИССЛЕДОВАНИЯ Изучить влияние направленности динамики МТ на формирование риска общей смертности и смертности от сердечно-сосудистых заболеваний (ССЗ) в когортном проспективном исследовании неорганизованной популяции города Томска. МАТЕРИАЛ И МЕТОДЫ Представлены результаты 10-летнего наблюдения мужчин и женщин с изученной предшествующей 17-летней динамикой МТ. Обследованы 1089 человек в возрасте 37—76 лет. В зависимости от направленности динамики МТ выделены группы: 1) МТ снизилась более чем на 5%; 2) стабильная МТ (±5% от исходной); 3) МТ увеличилась более чем на 5%. За период наблюдения умерли 166 человек. РЕЗУЛЬТАТЫ В проспективном когортном 10-летнем исследовании у лиц с ранее установленным снижением МТ по сравнению с лицами, у которых МТ не изменилась, выявлено увеличение риска общей смертности в 1,76 раза, риска смертности от ССЗ — в 1,73 раза. У лиц с абдоминальным ожирением потеря МТ также ассоциировалась с более высокой общей смертностью и смертностью от ССЗ. Наименьший 10-летний риск смертности наблюдался у лиц, у которых произошло увеличение МТ более чем на 5%, по сравнению с лицами, у которых МТ не изменилась или снизилась. ЗАКЛЮЧЕНИЕ При оценке риска общей смертности и смертности от сердечно-сосудистых заболеваний необходимо учитывать не только текущий показатель массы тела, но и направленность динамики массы тела.

Aim. To study the interdependence of spousal body mass and influence of spouse overweight on the death risk according to the 27-year cohort prospective study.Material and methods. We examined a random household sample (n=1546; married couples, 427). Overweight frequency among spouses was studied on the first stage of the study (1988-1991). In 2002-2005 (stage II), the examination was repeated and overweight dynamics were studied. In 2015 (stage III), we analyze mortality rates and significance of overweight and spousal overweight for the mortality risk formation. Overweight was detected in people with body mass index ≥25 kg/m2. Two hundred deaths were recorded during 27-year follow-up. Vital status was established for 97% of observed persons.Results. Overweight was detected in 61,1% of men who lived with overweight wife and in 45% of men whose wife had normal body mass (p<0,01). Overweight was diagnosed more often in women whose husband also had overweight comparing with women who lived with normal weight husband (76,2% vs 61,7%; p<0,001). The risk of overweight formation among individuals whose spouse’s body mass increased from norm to overweight was in 3,04 times higher than in persons whose spouse had a stable normal body mass and in 2,2 times higher than in participants whose spouse had overweight on study stages I and II. Relative risk of mortality in men who lived with overweight wife was 2,07.Conclusion. 1) We found the body mass concordance in spouses. 2) The average body mass index in men and women who lived with overweight spouse is higher than in men and women whose spouse had a normal body mass. 3) Interdependence of spousal body mass was revealed in dynamics. 4) Spousal overweight is an independent predictor of premature mortality in men.

The purpose of the review is to present an analysis of the current literature data on the pathogenesis and therapy of liver damage in Covid-19. Liver damage in COVID-19 patients can be caused by the direct cytopathogenic effect of SARS-CoV-2, an uncontrolled immune response, sepsis, severe hypoxia, or drug damage. In addition, COVID-19 can exacerbate and decompensate previously formed chronic liver diseases with the development of acute liver failure. Physicians should carefully assess the initial state of the liver, and after prescribing therapy, intensify monitoring of its functional state, especially in patients with severe COVID-19. In each clinical case, the doctor needs to establish the possible mechanisms of organ damage in order to select the most optimal patient management tactics, which would take into account all aspects of the COVID-19 course and liver damage. Currently, additional scientific information is required to uncover the features of liver damage during SARS-CoV-2 infection and in the postcovid period. Patients who have undergone COVID-19 need further monitoring to assess the long-term effects of the disease.

The review summarize existing international recommendations for managing patients with atrophic gastritis, intestinal metaplasia and gastric dysplasia. It is shown that patients with chronic anthropic gastritis or intestinal metaplasia have an increased risk of stomach adenocarcinoma development. Helicobacter pylori eradication tends to relieve indications of chronic nonatrophic gastritis and can lead to partial regression of atrophic gastritis, and reduces the risk of stomach cancer development.

Aim To study the effect of arterial hypertension (AH) in combination with frequent alcohol consumption on the formation of risk for cardiovascular death and all-cause death according to results of a 27-year prospective cohort study. Material and methods This 27‑year prospective cohort study of an unorganized population of the Tomsk city (1546 people aged 20–59 years, including 630 men and 916 women) investigated AH prevalence and alcohol consumption (1988–1991) and analyzed the predictive significance of the effect of AH in combination with frequent alcohol consumption on the formation of risk for all-cause and cardiovascular death. AH was diagnosed at blood pressure ≥140 / 90 mm Hg. Frequent alcohol users were defined as those who consumed alcohol more than once a week. Results The combination of AH and frequent alcohol consumption increased the risk of all-cause death 4.1 times compared to that for persons without these risk factors (p<0.001). This was true for all age groups of the total cohort (higher relative risk, RR, was observed for persons aged 20–39 years) and for men (except for the group aged 40–59 years). RR of cardiovascular death was 5.3 (p<0.001) for frequent alcohol users with AH. It was established that frequent alcohol consumption additionally increased RR of all-cause death for persons with AH (RR 1.89; p<0.05) primarily at the expense of persons aged 20-39 years. Prediction of 27‑year survival for frequent alcohol users with AH was 35.3 %. Conclusion A combination of AH with frequent alcohol consumption considerably increases the risk of all-cause and cardiovascular death. Frequent alcohol consumption significantly impairs the prediction of 27-year survival for persons with AH by additionally (1.9 times) increasing the risk of all-cause death. Binary AH combinations with frequent alcohol consumption exert a more pronounced adverse effect on young men and women.

The purpose of the review is to present an analysis of the literature data on the etiopathogenesis and therapy of liver diseases while Covid-19. Liver damage is common in patients with COVID-19, which can be caused by the direct cytopathic effect of the virus, an uncontrolled immune response, sepsis, or drug damage to the liver. Given the presence of ACE2 receptors in the liver, the liver is a potential target for SARS-CoV-2. Moreover, COVID-19 may exacerbate underlying chronic liver disease, leading to hepatic decompensation, acute liver failure, associated with higher mortality. Doctors should carefully assess the initial state of the liver, pay attention to changes in the course of underlying liver disease, and during treatment should intensify monitoring and evaluation of liver function in patients with severe disease. The physician should establish the causes of liver damage in combination with the pathophysiological changes caused by COVID-19 and based on active treatment of the underlying disease, prescribe treatment to protect the liver to reduce the degree of liver damage. Additional data are currently required to clarify the nature and extent of liver damage, and to determine approaches to therapy in patients with COVID-19.

In 2019, a retrospective analysis of medical records for 10 previous years (2019-2009) was conducted for 426 patients with confirmed malignant neoplasm (MN) of the stomach registered in 125 outpatient and polyclinic medical and preventive treatment facilities in 12 cities of the Russian Federation. The average age of patients at the time of diagnosis was 61.9 years, the life expectancy after diagnosis being 2.2 years. In 67.4% of patients the diagnosis was made at stages III and IV of the disease. All patients had a history of any upper digestive tract pathology. The record of H. pylori c examination was detected in 16.9% of patients, all of them with positive results. In 64,3% of esophagogastroduodenoscopy (EGDS) protocols there were visible changes in the gastric mucosa. Dynamic EGDS control was performed irregularly. During the whole period of observation, an average of 2.5 biopsies per patient were taken during EGDS. In the clinical diagnosis of “chronic gastritis” morphological examination was performed in 70.0% of patients. Classical “warning signs” were registered on the average 2.4 years before the diagnosis of gastric cancer. Dyspepsia syndrome was registered 4.6 years before cancer verification. The correlation between dyspepsia and the timing of cancer diagnosis was confirmed. Thus, the dyspepsia syndrome can be categorized as “early warning signs”. For the diagnosis of gastric adenocarcinoma, 3D correlation analysis showed a correlation between the number of biopsy samples taken, the number of “warning signs” and the number of years lived after the diagnosis of malignant neoplasms.

Metabolically associated fatty liver disease is a widespread disease (MAFLD).The main treatment strategy for MAFLD is the correction of metabolic factors, changes in lifestyle, normalization of body weight, which is achieved by the use of diet therapy and physical activity.The purpose of this review is to present the characteristics of diets that have been studied in the treatment of patients with MAFLD.Results. The greatest evidence base on the effectiveness of treatment of MAFLD and the safety profile is the use of the Mediterranean diet and the diet with a low glycemic index. Patients should be advised to reduce their sugar intake, reduce their intake of saturated fatty acids and trans fats, and increase their intake of dietary fiber. Eating a balanced, calorie-restricted diet can help to provide healthy lifestyle and healthy eating habits, which are essential for the prevention and treatment of MAFLD. Hereditary factors, the composition of the intestinal microbiota, comorbid pathology can affect the results of diet therapy, which emphasizes the urgent need for an individualized approach in the treatment of this disease.

Gastritis is a reaction of the mucous membrane (MM) of the stomach to damage and is characterized by the formation of inflammatory, dystrophic and dysregenerative changes in the MM of the stomach, as well as atrophy of epithelial cells with replacement of normal glands with fibrous tissue. The progression of chronic gastritis (CG) is accompanied by the development of MM atrophy, dysplasia and becomes a significant factor in the formation of gastric malignant neoplasms. The article presents the modern etiological classification of CG, approaches to the diagnosis of CG, assessing the stage of gastritis on a scale of progressive increase in the likelihood of developing stomach cancer, presents the histological characteristics, and also substantiates etiopathogenetic approaches to the treatment of various forms of CG, including methods for optimizing the eradication therapy of H. pylori infection. which can be used to increase the effectiveness of not only standard triple therapy, but also other anti-Helicobacter treatment regimens. The use of proton pump inhibitors in the treatment of gastritis is considered.

The aim of the study was to evaluate the timeliness and eff ectiveness of the diagnosis of precancerous diseases and early forms of gastric cancer in primary health care. Materials and methods. A multicenter retrospective descriptive study was conducted with an analysis of the medical records of 426 patients who were diagnosed with malignant neoplasm of the stomach at the time of going to outpatient facilities. We used data from 125 outpatient facilities in 7 centers for the period from 2009 to 2019. Results. The average age of patients with a fi rst established diagnosis of malignant neoplasia was 61,7 (95% CI 58.6 ÷ 64.8) years. The prevailing form of malignant neoplastic disease was the option “Adenocarcinoma, intestinal cancer” — 77,7%, diff use type cancer — 12,7%, other histological types — 9,6%. The diagnosis of malignant neoplastic disease at the III and IV stages of the disease was fi rst established in 67,4% of patients. The number of years lived by patients with a diagnosis of gastric gastric cancer was 2,0 years. Over a 10-year follow-up, 75% of patients died. Risk factors for gastric cancer were identifi ed in 41% of respondents. Signs of dyspepsia syndrome were observed in 31,5% of patients, and they appeared on average 4,6 (95% CI 4,4 ÷ 4,8) years before the diagnosis of gastric malignancy. Among people with gastric cancer, dyspepsia symptoms occur every day in every third patient. The features of the manifestations of dyspepsia in the observed patients were: daily manifestations of symptoms (33,3%), symptoms at night — 9,4%, an increase in the intensity of dyspepsia (21,3%), the lack of a clinical response to the therapy (proton pump inhibitors, prokinetics, eradication of Helicobacter pylori infection) in 58% of cases. Anxiety symptoms were recorded 2,4 years before a diagnosis of stomach cancer.

Aim. To study the influence of arterial hypertension (AH), smoking, and their combination on the risk of all cause and cardiovascular mortality.Material and methods. We conducted a 27-year cohort prospective study of the unorganized population of Tomsk (916 women and 630 men aged 20-59 years). At the first stage, we studied the prevalence of AH and smoking (1998-1991), at the second (2015) — the effect of these risk factors (RF) and their combination on the risk of all cause and cardiovascular mortality. AH was diagnosed at a blood pressure level of >140/90 mmHg and <140/90 mm Hg in individuals taking antihypertensive drugs. Smokers were individuals who smoked at least 1 cigarette per day and quit smoking less than one year ago.Results. The study found a significant effect of AH and smoking on mortality: the relative risk (RR) of all-cause mortality in people with hypertension was 2,2, in smokers — 2,3, in those with a combination of RF — 5,0. The RR of cardiovascular mortality in AH individuals was 3,4, in smokers — 1,6, in smoking men and women suffering from AH — 5,2. An increase in the risk of all-cause mortality in people with AH and smoking was observed in all gender-age groups. Smoking was found to increase the risk of all-cause mortality in individuals with high levels of blood pressure by 2,1 times compared with non-smoking hypertensive patients. It reduces the chances of a 27-year survival rate to 64,4%, and more so in the youngest (20-39 years) age group (RR — 3,9). Multivariate analysis showed that AH and smoking make the most significant contribution to the formation of mortality compared to other modifiable RFs.Conclusion. We found that AH and smoking are among the most influential RFs, and their combination increases the RR of all-cause mortality by 5,0 times (cardiovascular — 5,2 times). We also determined an additional risk of smoking in individuals suffering from AH to the all-cause mortality.

The aim. On clinical examples to demonstrate to the Therapist and General practitioner the possibility of using the road-map of management of primary patients with symptoms of dyspepsia at the stage of outpatient care. Fundamentals. Clinical cases of patients with established diagnoses of Functional dyspepsia; Dyspepsia associated with Helicobacter pylori infection; Nonerosive reflux disease; Gastroesophageal reflux disease of I degree with nocturnal acid breakthroughs in combination with functional dyspepsia are presented. The questions of substantiation of preliminary and final diagnoses, approaches of differential diagnosis of diseases using the road-map are considered in the comments. The main methods of diagnosis of diseases and disorders with symptoms of dyspepsia are presented and justified. It is shown that prior to obtaining the results of esophagogastroduodenoscopy, a preliminary diagnosis Uninvestigated Dyspepsia “K 31.9 Disease of stomach and duodenum, unspecified” should be made. After elimination of the organic cause of dyspepsia, treatment is carried out using proton pump inhibitors (omeprazole or rabeprazole 20 mg/day) in combination with a prokinetic (domperidone 30 mg/day). Rational use of a fixed combination of omeprazole 20 mg with modified release domperidone 30 mg / day (Omez®DSR). Conclusion. Compliance with the algorithm of management of primary patients with symptoms of dyspepsia in a wide clinical practice will avoid errors in the diagnosis, the appointment of unreasonable research, irrational treatment, which will improve the quality of life and prognosis of patients with dyspeptic disorders.

The objective of the paper is to study the effects of anaerobic exercise on fatty acids percentage in adipose tissues of different localization under high-calorie diets in rats. Materials and Methods. The authors examined Wistar rats under high calorie diets (32 % fat content). In the first group the animals were not exposed to any physical exercise. In the second group rats were exposed to anaerobic physical activity, namely swimming. The percentage of 24 fatty acids (FA) and the value of 14 integrative indicators (complexes) in the depot of visceral and subcutaneous adipose tissues were determined using chromatography-mass spectrometry (Agilent Technologies, USA). Results. Anaerobic exercise led to an increase in saturated FAs in the mesenteric adipose tissues and to a decrease in unsaturated FAs, as well as to a decrease in the unsaturation index; an increase in the retroperitoneal adipose tissue of the FA sphingophospholipid substrates, FA membrane substrates, a decrease in the energy substrates, an increase of vitamin F FA substrates due to ω6 of unsaturated FAs. At the same time, a decrease in the amount of polyunsaturated FAs was observed in the subcutaneous depot, and the balance between ω3/ω6 shifted towards ω6 of unsaturated FAs. In the mesenteric and retroperitoneal adipose tissues, there was a decrease in monounsaturated FAs due to ω9 of unsaturated FAs, and the ratio of saturated FAs/monounsaturated FAs shifted towards saturated FAs. Only in retroperitoneal adipose tissues there was a decrease in ω7 of saturated FAs due to C16: 1 ω7. Conclusion. Regular anaerobic exercise and a high-calorie diet showed the most pronounced effect on FAs in visceral adipose tissues, namely in mesenteric and retroperitoneal tissues. Keywords: fatty acids, fatty acid complexes, adipose tissues, anaerobic exercise, high-calorie diet. Цель – исследовать воздействие анаэробной физической нагрузки на процентное содержание жирных кислот в жировой ткани разной локализации на фоне питания повышенной калорийности у крыс. Материалы и методы. В исследовании использовали крыс линии Wistar, находящихся на питании повышенной калорийности (с долей жира 32 %). В первой группе животных физическая нагрузка отсутствовала, крысы второй группы получали физическую нагрузку преимущественно анаэробного характера в виде плавания. Процентное содержание 24 жирных кислот (ЖК) и значение 14 интегративных показателей (комплексов) в депо висцеральной и подкожной жировой ткани определяли на хромато-масс-спектрометре (Аgilent Technologies, США). Результаты. Анаэробная физическая нагрузка привела к увеличению содержания в мезентеральной жировой ткани насыщенных ЖК (НасЖК) и снижению ненасыщенных ЖК (НЖК), а также снижению индекса ненасыщенности; увеличению в забрюшинной жировой ткани ЖК-субстратов сфингофосфолипидов, ЖК-субстратов мембран, снижению субстратов энергии, увеличению содержания ЖК-субстратов витамина F за счет ω6 НЖК. При этом в подкожном депо наблюдалось снижение суммы полиненасыщенных ЖК, а баланс ω3/ω6 сместился в сторону ω6 НЖК. В мезентериальной и забрюшинной жировой ткани отмечалось снижение содержания мононенасыщенных ЖК (МНЖК) за счет ω9 НЖК, а соотношение НасЖК/МНЖК сместилось в сторону НасЖК. Только в забрюшинной жировой ткани было установлено снижение содержания ω7 НЖК за счет С16:1 ω7. Выводы. Регулярная анаэробная физическая нагрузка на фоне питания повышенной калорийности продемонстрировала наиболее выраженное влияние в отношении ЖК в висцеральной жировой ткани, а именно в мезентериальной и забрюшинной. Ключевые слова: жирные кислоты, комплексы жирных кислот, жировая ткань, анаэробная физическая нагрузка, диета повышенной калорийности.