Objective:Persistent infection of high-risk human papillomavirus is the main cause of cervical cancer, so HPV typing test has a defensive effect on the early screening of cervical cancer. This paper mainly analyzes the infection situation of different types of HPV in women in Shanxi Province.Methods:A total of 48 661 samples of HPV screening at Taiyuan Jinyu Clinical Laboratory Co., Ltd were selected from October to December 2021 and statistically analyzed by reverse point hybridization.Results:The rate of HPV-positive infection in 48 661 cervical detached cell samples was 20.57%, including 17.73% for high-risk HPV infection and 5.22% for low-risk HPV infection. The number of HPV infected persons with single type was more than that of multi-type co-infected patients, among which the single high-risk type was the majority (58.67%), followed by the mixed high-risk types (15.94%). Among the 23 HPV genotypes, high-risk HPV types are susceptible to infection: HPV52, 16, 53, 58, 51 and 56; low-risk HPV types are susceptible to infection: 81, 42, and 43. Analysis of the infection in 5 age groups showed that the infection rate of women over 55 years old was the highest (32.63%).Conclusions:From the above data, it can be found that the HPV infection rate of women over the age of 55 in Shanxi Province is relatively high. It is necessary to strengthen the publicity of cervical cancer and the relationship between HPV, regular HPV screening, and early detection and treatment of cervical precancerous lesions, so as to effectively prevent the occurrence of cervical cancer.

Objective:Study the gene polymorphism of CYP2C19 in patients with cardiovascular and cerebrovascular diseases, analyze whether it is related to age and sex differences, and provide guidance for the individualized medication of clopidogrel.Methods:Using real-time PCR, to monitor the genotype of CYP2C19 for 776 patients with cardiovascular and cerebrovascular diseases,who were considered to receive clopidogrel antithrombotic therapy,and the correlation between age, sex and their genetic polymorphisms was analyzed.Results:Four genotypes were detected, which were CYP2C19*1/*1 (42.14%), *2/*2 (10.82%), *3/*3 (1.03%) and *3/*17 (46.01%). The three metabolic phenotypes were extensive metabolizer/EM (42.14%), intermediata metabolizer/IM (46.01%) and poor metabolizer/PM (11.85%). The metabolic phenotypes were similar to those of related report. The CYP2C19 genotype and metabolic phenotype was associated with an increased rate of male and female patients (all P＜0.05). There was no significant difference among patients of different age in CYP2C19 genotype and metabolic phenotype (all P＜0.05).Conclusions:The patients with cardiovascular and cerebrovascular diseases in Shanxi are mainly EM and IM patients, which is in line with Asian population distribution, and the number of patients with genotype CYP2C19 *1/*1 and *3/*17 is the largest. At the same time, it can not be considered to be guided according to the differences of CYP2C19 genotype, metabolic phenotype and the age, sex in drug use, still need according to the patient's own situation to give individualized medication treatment.