Objective: To prepare antibacterial resin cement containing photocurable triclosan derivative, and to evaluate its characterization performance, mechanical properties, adhesive strength, antibacterial properties, and cytotoxicity in vitro. Methods: The photocurable triclosan derivative（TCS-IH） was dissolved in acetone at 25 wt% and then added to Multilink Speed at a mass ratio of 0 wt%, 2 wt%, 4 wt%, 6 wt%, and 8 wt%, to obtain the resin cement with antibacterial properties for different components. FTIR was used to examine the conversion of double bonds before and after curing of resin cement in each group. The surface wettability of resin cement in each group was examined by static water contact angle. Its flexure strength was tested with a three-point bending test. Micro-tensile test was used to examine its instant bonding properties. S.mutans was selected for antibacterial experiments, and the antibacterial properties of resin cements were evaluated by colony counting, MTT, and live/dead bacterial fluorescence staining. The cytotoxicity grade in vitro was evaluated by CCK-8 cytotoxicity assay. Results: The addition of TCS-IH acetone solution at 2 wt% and 4 wt% had no significant effect on characterization performance, mechanical properties, and bonding strength of resin cement（P＞0.05）. When the mass percentage of TCS-IH reached 4 wt%, 6 wt%, and 8 wt%, resin cement all showed significant antimicrobial activity（P＜0.05）. Both 2 wt% and 4 wt% resin cements had good biocompatibility. Conclusion: When the mass percentage of TCS-IH was 4 wt%, the antibacterial properties of resin cement were effectively improved while its characterization properties, mechanical properties, adhesive properties, and biosafety were not affected.

牙本质粘接依靠粘接剂渗透到脱矿的胶原纤维网状结构和牙本质小管内并原位聚合,形成混合层和树脂突获得主要粘接固位力[11.牙本质因有机物含量高和粘接剂中聚合物降解等因素难以形成高质量的混合层[1～4].粘接界面是牙本质粘接的薄弱环节,其混合层质量及抗老化性能是影响粘接耐久性的关键.

OBJECTIVE:The aim of this study was to evaluate the ability of 4-formylphenyl acrylate (FA) to enhance the bond strength and stabilize the resin-dentin bonding interface of universal adhesives in self-etching mode over time.METHODS:Different concentrations of FA (1%, 3%, 5%, 7%, 9%) were prepared as primer. The optimal group was selected according to degree of conversion of 2 universal adhesives (Single Bond Universal (SBU)/All-Bond Universal (ABU)), and grouped according to the pre-treatment time (30s, 1min, 2min). The micro-tensile strength before and after 10,000 times thermocycling aging was used to evaluate the bonding performance.RESULTS:The 1min application of FA (5%) increased the conversion rate of the adhesive. The expressions of microtensile bond strength and nanoleakage in the FA treatment group did not decrease significantly compared with their immediate values even after 10,000 thermocycling of aging. In situ zymography results showed that the hydrolytic activity of endogenous proteins decreased significantly in FA-1min group.CONCLUSIONS:Treatment by FA primer can effectively enhance the bond stability at the bonding interface.CLINICAL RELEVANCE:FA can be used as a functional monomer in self-etching bonding system to dentin, which not only had high biocompatibility, but also can show good collagen cross-linking ability within clinically acceptable application time.

有限元分析是利用数学计算分析真实的物理系统,计算模型赋予材料的参数,将任意几何结构分成有限个小的单元体,之间通过节点连接,计算每个结构中的形变、应力和所产生的变量,从而模拟分析真实条件情况[1,2].并可对具有复杂性质材料组成的不规则几何结构进行建模,模拟出复杂载荷与边界条件的情况[3,4].使用这种方法,可分析获得口腔修复材料的理想特性[5].

This review aims to evaluate whether the etch-and-rinse or self-etch mode is the better protocol for dentin adhesion by universal adhesives. A total of 15 articles were included in the meta-analysis. Two reviewers performed a literature search up to October 2020in four databases: PubMed, Web of Science, Embase, and the Cochrane Library. Without considering the difference in aging mode, the analysis of the immediate and long-term bond strength of dentin showed that there was no statistical significance between the etch-and-rinse and self-etch mode of universal adhesive, and the long-term bond strength decreased relative to the immediate. In vitro studies suggest that prior acid etching did not improve bond performance. Whether from the perspective of long-term bonding performance or simplifying operating procedures, the self-etch mode is preferred.

近几十年,牙本质粘接剂历经多代改良趋向多功能化和操作简便化,并在口腔修复治疗中广泛应用.为获得理想的远期修复效果,牙本质粘接剂在具备良好的物理化学和机械性能基础上,还需具备有效的抗龋性能.该文将重点从抗菌肽的抗菌作用机制、抗菌肽的种类、在牙本质粘接剂中的应用及防龋效果等方面展开综述,并对抗菌肽在牙本质粘接剂应用中面临的挑战和发展前景作出展望.

Objectives For a conventional indirect restoration, temporary cementation inevitably contaminated collapsed dentin collagen. The purpose of this review was to evaluate the optimal strategy for minimizing its negative effects. Material and methods Databases such as PubMed, Web of Science, EMBASE, and the Cochrane Library were searched for in vitro studies, involving the influence of immediate dentin sealing (IDS), different temporary cements, and their removal strategies on dentin bond strength. The meta-analysis used the inverse variance method with effect method of the standardized mean difference and statistical significance at p ≤ 0.05. The I 2 value and the Q -test were used to assess the heterogeneity. Results A total of 14 in vitro trials were subjected to the meta-analysis. Within the study’s limitations, we assumed that IDS eliminated the negative effects of temporary bonding, achieving the comparable immediate bond strength with the control ( p = 0.46). In contrast, under delayed dentin sealing (DDS), temporary cementation statistically decreased bond strength ( p = 0.002). Compared with resin-based and non-eugenol zinc oxide cements, polycarboxylate and calcium hydroxide cements performed better on bond strength with no statistical difference from the control group ( p > 0.05). Among the removal methods of temporary cements, the Al 2 O 3 abrasion restored the decreased bond strength ( p = 0.07) and performed better than hand instruments alone ( p = 0.04), while pumice removal slightly reduced the bond strength in contrast with the control group ( p = 0.05, 95% CI = − 1.62 to 0). Conclusions The choices of IDS, polycarboxylate and calcium hydroxide temporary cements, Al 2 O 3 abrasion removal method were feasible and efficient to enhance the bond strength. Clinical relevance It is worthwhile applying IDS technique, polycarboxylate and calcium hydroxide temporary cements during indirect restoration. The Al 2 O 3 abrasion of cleaning dentin can minimize the negative effects of temporary cement.

Secondary caries is one of the main causes of dental zirconia restoration failure in the clinic. Therefore, it is urgent to improve the antibacterial performance of zirconia ceramics to reduce the occurrence of secondary caries. In this study, a quaternary ammonium compound antibacterial polymer was innovatively synthesized by solution polymerization with a quaternary ammonium salt monomer as the antibacterial component. The antibacterial epitaxial transition layer was successfully prepared on the surface of zirconia ceramics by the hydroxyl group on HEMA reacting with the siloxane group in the KH570 hydrolysate, which makes the antibacterial polymer indirectly chemically combine with the silicate epitaxial transition layer. The antibacterial epitaxial transition layer exhibited excellent mechanical properties, satisfactory biocompatibility and significant antibacterial effects, and the maximum antibacterial rate is 99%. The antibacterial epitaxial transition layer plays an important role in preventing secondary caries and improving the success rate of clinical zirconia ceramic restorations.

成功的修复体必须具备功能性和耐久性,提高树脂-牙本质粘接界面耐水解和酶促降解对于提高粘接修复的耐久性至关重要.粘接界面再矿化有助于解决该问题.该文主要对仿生类似物诱导树脂-牙本质粘接界面再矿化的机制、常用产物及其表征做一综述.