for assessing the therapeutic value of medicines are not used in the Russian Federation. Here we propose a method for estimating the therapeutic value of innovative medicines based on the multi-criterial analysis.

Clinical guidelines are systematically developed statements aimed to assist practitioners and patient decisions about appropriate medical care for specific clinical circumstances. The key principle for the guideline development is the provision for decision-making on the implementation of certain medical technologies should be based on a comprehensive  analysis of all available scientific evidence, assessment of their  effectiveness and safety. The objective of the article is to define unified methodology for evaluation of the evidence reliability and the  credibility for recommendations when developing or updating clinical guidelines.

The description of the international practice of governmental funding of biomedical research is a significant aspect of development of the methodology for prioritization of funding of science (both basic and applied research) in the Russian Federation. The information about mechanisms of allocation of the governmental budget in biomedical research and about focus themes within biomedical research founded in open information sources is very limited.