To evaluate the effectiveness of neuromuscular compression bandage in preventing seroma after surgical treatment of breast cancer. This randomized clinical trial included women over 18 years old undergoing mastectomy. The control group followed the institution’s standard routine of using a suction drain, whereas the intervention group was assigned to receive a compressive bandage for 1 week in addition to the drain. A total of 124 women were assigned to the intervention group and 125 to the control group. There was no statistically significant difference in sociodemographic, clinical, or treatment variables, nor in the incidence of seroma between groups (odds ratio [OR], defined as the ratio between the odds of an event occurring in the intervention group versus the control group = 1.59; 95

Introduction Sentinel lymph node biopsy (SLNB) can be indicated for patients undergoing neoadjuvant chemotherapy (NACT); however, few studies have validated SLNB after neoadjuvant treatment in patients with advanced clinical staging. Method Cross-sectional study to validate SLNB in patients diagnosed with T4 tumors and/or axillary N2 breast cancer who received NACT and presented with a clinically negative axilla (cN0) preoperatively. After neoadjuvant treatment, patients underwent SLNB using dual mapping with radiotracers and/or patent blue, followed by axillary lymph node dissection according to institutional protocol. Patients in whom SLNB was not feasible due to anatomical reasons were excluded. Sociodemographic, clinical, tumor-related, and treatment-related variables were collected. Validity was assessed using the detection rate, false-negative rate, sensitivity, negative predictive value (NPV), and accuracy. Results A total of 47 patients were included; 82.9% had T4 clinical staging and 34% had N1 disease, of whom all T4 and 31.9% were N2. The detection rate of SLNB was 76.6%, and the false-negative rate was 6.6%. Sensitivity, NPV, and accuracy of SLNB were 94.4%, 93.3%, and 86.1%, respectively. Conclusion SLNB for patients with T4 tumors and/or axillary N2 disease who have a clinically negative axilla after neoadjuvant treatment is feasible and safe.

PURPOSE:Despite advances in breast cancer treatment, delays in care delivery remain a major challenge in many health systems, particularly in low- and middle-income countries. Evidence evaluating adherence to oncology quality metrics within public health systems remains limited. This study evaluated adherence to breast cancer treatment timeliness quality metrics in a Brazilian public referral hospital using established benchmarks (ASCO and ESMO) alongside Brazil's national 60-day treatment law and identified factors associated with delayed treatment initiation. MATERIALS AND METHODS:This retrospective cohort study included women with stage I-III breast cancer treated at the Brazilian National Cancer Institute between 2016 and 2018. Adherence to six treatment timing quality metrics was evaluated, and multivariable logistic regression models were used to identify factors associated with delayed treatment initiation. RESULTS:A total of 966 patients were included. Only 35% of patients with hormone receptor-positive tumors initiated endocrine therapy within the recommended timeframe, and 23.6% of those undergoing breast-conserving surgery received radiotherapy within 365 days. In the ESMO-Q cohort, only 0.2% initiated chemotherapy within 120 days of diagnosis. Patients with Luminal A-like tumors were more likely to initiate treatment within recommended timeframes, whereas younger age and locally advanced disease were independently associated with treatment delays. CONCLUSION:Substantial delays in breast cancer treatment initiation were observed across all evaluated quality metrics within the Brazilian public health system, revealing a marked gap between recommended treatment timelines and real-world care delivery. Improving adherence to national and international quality benchmarks will require a better understanding of the patient- and system-level factors associated with treatment delays and the implementation of targeted interventions across the cancer care continuum. MICRO ABSTRACT:This retrospective cohort study evaluated adherence to international (ASCO, ESMO) and national quality metrics for breast cancer care in Brazil's public health system. Marked delays in treatment initiation were observed across endocrine therapy, radiotherapy, chemotherapy, and surgery, highlighting important gaps in timely cancer care delivery.

OBJECTIVES:Cancer-related fatigue (CRF) is one of the most prevalent and debilitating symptoms among women undergoing neoadjuvant chemotherapy for breast cancer. This study analysed fatigue trajectories and identified modifiable determinants of fatigue worsening. METHODS:Prospective cohort of women with stage I-III breast cancer treated with neoadjuvant chemotherapy at a national cancer centre. Fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), clinical data, physical activity, handgrip strength, depressive symptoms, pain, insomnia and anaemia were assessed at baseline and across chemotherapy cycles. Generalised estimating equations modelled fatigue variation over time. RESULTS:Fatigue remained stable after anthracyclines but worsened significantly during the taxane phase. Independent determinants of greater fatigue worsening included overweight/obesity, insomnia, depressive symptoms, pain, anaemia and lower handgrip strength. Moderate-to-vigorous physical activity was protective. CONCLUSIONS:Several modifiable factors contributed to CRF worsening during neoadjuvant treatment. Early identification and management of these conditions may mitigate fatigue progression and improve quality of life and treatment tolerance.

OBJECTIVE:To examine the effects of 16 weeks of Mat Pilates or belly dance, compared with a control condition, on cardiorespiratory fitness and body composition in women with breast cancer undergoing hormone therapy, with follow-up at 6 and 12 months. METHODS:In this randomized clinical trial, 52 women were allocated to Mat Pilates (n = 18), belly dance (n = 18), or control (n = 16) groups. Exercise groups trained three times per week for 60 min over 16 weeks. The control group maintained usual activities and attended educational sessions. Outcomes included peak oxygen uptake (V̇O₂peak) via submaximal cycle ergometer, 6-min walk test (6MWT), perceived exertion, waist circumference, body mass index (BMI), and fat percentage (determined using ultrasound). Assessments occurred at baseline, post-intervention, and at 6- and 12-month follow-ups. RESULTS:Post-intervention, the belly dance group showed a greater 6MWT improvement (+83.1 m; p = 0.016) and lower perceived exertion at 35 W (p = 0.019) than controls. Waist circumference decreased across all participants (p < 0.001), with the largest reduction in the Mat Pilates group (-9.8 cm). No significant changes were observed in V̇O₂peak immediately post-intervention. At follow-up, both exercise groups showed decreased fat percentage (p = 0.002) but increased waist circumference (p < 0.001). V̇O₂peak declined in the belly dance group at both 6 and 12 months (p < 0.001). CONCLUSION:Mat Pilates and belly dance improved functional capacity and reduced abdominal circumference in women with breast cancer receiving hormone therapy. Despite some loss of benefits at follow-up, sustained reductions in fat percentage suggest these modalities may be valuable in oncological rehabilitation programs. CLINICALTRIALS: GOV REGISTRATION:NCT03194997.

OBJECTIVE:To compare the static stiffness index (SSI) between a compression garment and a ReadyWrap (Venosan, Brazil) adjustable compression garment (ACG), and analyse the clinical factors associated with increased SSI in patients with breast cancer-related lymphoedema (BCRL). METHOD:In this cross-sectional study, working pressure (WP) and resting pressure (RP) were assessed using a PicoPress device (Venosan, Brazil) positioned under the biceps muscle in the arm region. The SSI was calculated as the absolute and relative difference between the RP and the highest WP recorded during muscle contraction. RESULTS:The study included 76 patients with a mean age of 61.7±12.6 years. During compression garment use, the mean RP was 21.9mmHg and mean WP was 40.0mmHg during biceps brachii contraction, resulting in an absolute SSI of 18.1mmHg and a relative SSI of 43.6% (p<0.001). For the ACG, the mean RP was 19.3mmHg and mean WP was 63.1mmHg, resulting in a mean SSI of 43.8mmHg and a relative SSI of 68.7% (p<0.001). The ACG produced an SSI 25.7mmHg greater than the compression garment, a 25.1% relative difference (p<0.001). The compression garment showed a higher SSI in early-stage versus advanced-stage patients (8.2%; p=0.003) and in those with conservative surgeries versus mastectomy (8.3%; p=0.005). No SSI difference was observed for the ACG when considering tumour characteristics and oncological treatment. CONCLUSION:The SSI was greater with ACG use compared with the compression garment. Patients who had breast-conserving surgeries and early-stage tumours showed the highest SSI when using the compression garment. No SSI differences were found regarding patient demographic, clinical, tumour or treatment characteristics during ACG use.

Background Younger patients are not included in routine screening for breast cancer (BC) and can have delays in diagnostic evaluation. Particularly in Brazil, approximately 40% of women with breast cancer are diagnosed with late stage disease (III or IV), emphasizing persistent barriers to timely diagnosis and specialized care by the public healthcare coverage (The Brazilian Unified Health System; Sistema Único de Saúde; SUS). This study aims to estimate the frequency of late-stage BC (stages III or IV) at diagnosis among young women treated by (SUS) and identify associated sociodemographic and clinical factors. Material and methods Cross-sectional nationwide population-based study conducted to analyze data from the national Hospital Cancer Registry, including women aged 15 to 39 years diagnosed with BC, between 2000 and 2023. Results Nearly half (48.2%) of young women with breast cancer in Brazil are diagnosed at late stages (III–IV). In the multivariate analysis, self-reported Black or brown race (OR 1.18; 95%CI 1.12–1.25), education <9 years (OR 1.22; 95%CI 1.15–1.29), absence of a partner (OR 1.09; 95%CI 1.04–1.15), invasive carcinoma subtype of no special type (OR 1.16; 95%CI 1.08–1.25) and referral by the public system (OR 1.31; 95%CI 1.19–1.44) registered an independent association with late stage. Conclusion Brazil faces a high rate of late-stage breast cancer diagnoses among young women and the independent predictors of late presentation emphasizes the impact of social and structural inequities on oncology care. MicroAbstract Although breast cancer predominantly affects women older than 50 years, recent evidence has shown an increasing incidence among women younger than 40 years. Assessing nationwide data from the Brazilian Hospital Cancer Registries, this study analyzed 52,734 women aged 15–39 years and found that 48.2% were diagnosed with stage III–IV disease. Late presentation was independently associated with social vulnerability markers, including race, lower education, absence of a partner, and referral through the public health system. These findings highlight structural inequities in cancer care and provide evidence to inform policies aimed at improving early diagnosis in young women.

IntroductionMalnutrition and changes in body composition are common in pediatric cancer patients and are often underestimated during outpatient care. Simple anthropometric tools and functional assessments may enhance nutritional screening and clinical monitoring in this population. This study aims to investigate the relationship between anthropometric indicators, handgrip strength (HGS), and dietary intake in children and adolescents undergoing cancer treatment, compared to healthy peers.MethodsA cross-sectional study was conducted with 45 participants (15 cancer patients and 30 age- and sex-matched controls). Assessments included arm and calf circumferences, tricipital skinfold, arm muscle circumference, HGS via dynamometry, and a 3-day dietary record classified using the NOVA system.ResultsThe cancer group reported significantly lower consumption of ultra-processed foods compared to controls (p = 0.039). Anthropometric indicators and HGS were significantly lower in the cancer group (p < 0.05). A strong positive correlation was found between HGS and calf circumference (r > 0.80). In the total sample, 42.2% were eutrophic, while 51.1% were classified as overweight or obese.ConclusionHGS and basic anthropometric measurements may serve as supportive tools for early identification of nutritional risk. Integrating these indicators into routine outpatient care may support targeted interventions and promote dietary quality in children with chronic illnesses.

Introdução: A quimioterapia neoadjuvante, utilizada no tratamento do câncer de mama, pode ocasionar sintomas e comprometer a funcionalidade, repercutindo na qualidade de vida relacionada à saúde (QVRS). Objetivo: Avaliar as alterações na QVRS ao longo da quimioterapia neoadjuvante em mulheres com câncer de mama. Método: Coorte prospectiva com mulheres diagnosticadas com câncer de mama, incluídas no grupo controle de um programa de pré-habilitação. A QVRS foi avaliada antes do início e após o término da quimioterapia neoadjuvante por meio dos questionários da European Organization for Research and Treatment of Cancer: Core 30 (EORTC QLQ-C30) e da Breast Cancer Module (EORTC QLQ-BR23). Foram realizadas análises descritivas e comparação das médias pelo teste t pareado. Resultados: Participaram 51 mulheres, com média de idade de 52 anos. Após a quimioterapia neoadjuvante, observou-se declínio significativo nas funções física (p=0,001) e sexual (p=0,016), além de agravamento da fadiga (p=0,042) e dos efeitos da terapia sistêmica (p=0,036). Em contrapartida, houve melhora na insônia (p=0,026), no estado de saúde global (p=0,048) e nos sintomas mamários (p=0,001). Conclusão: Durante a quimioterapia neoadjuvante para o câncer de mama, mulheres apresentaram alterações relevantes na QVRS, caracterizadas por declínio funcional e intensificação de sintomas sistêmicos, concomitantes à melhora de sintomas mamários e do estado de saúde global, ressaltando a importância do monitoramento contínuo da QVRS ao longo do tratamento.

To evaluate the short-term (16 weeks post-intervention) and long-term effects (six- and 12-month follow-up) of two physical exercise interventions—Mat Pilates or belly dance—compared with a control group on lymphedema, range of motion, isometric strength, proprioception, and upper-limb symmetry in women who have undergone unilateral breast cancer surgery and are receiving hormone therapy. Sixty-nine women who underwent unilateral breast cancer surgery were randomized into three groups: Mat Pilates, belly dance, and control. The Mat Pilates and belly dance groups participated in supervised exercise sessions three times per week, lasting 60 min each, for 16 weeks. The control group continued their usual daily activities and attended three educational lectures. The outcomes assessed included upper-limb functionality (DASH), lymphedema (arm volume), range of motion (digital goniometer), isometric strength (dynamometer), and limb symmetry (difference between the contralateral and homolateral limbs). In the Mat Pilates group, post-intervention effects were observed in increased range of motion (p = 0.026), improved isometric strength (p = 0.001), and enhanced strength symmetry between limbs (p = 0.034). In the belly dance group, post-intervention improvements were identified in upper-limb functionality (p = 0.001), lymphedema (p = 0.017), isometric strength (p = 0.001), and symmetry of both range of motion (p = 0.041) and strength between limbs (p = 0.009). However, none of these gains were sustained at follow-up assessments. No significant intragroup changes were observed in the control group. Mat Pilates and belly dance were effective in improving upper-limb functionality, range of motion, lymphedema, isometric strength, and limb symmetry in breast cancer women undergoing hormone therapy. Both forms of physical exercise may be recommended by professionals involved in oncological rehabilitation. ClinicalTrials.gov (NCT03194997) Registration June 20, 2017.

Introduction: Physiotherapy plays a vital role in palliative care for patients with advanced cancer. However, access to physiotherapy is often limited in resource-limited communities. To address this gap, a screening tool tailored to clinical needs and contextual constraints is needed. Objective: To develop and validate the content of the FisioCan-CP, a physiotherapy screening tool for patients with advanced cancer receiving palliative care in resource-limited communities. Methods: A methodological study was conducted in two phases: (1) development of the instrument based on clinical data, targeted literature review, and expert brainstorming; and (2) content validation by Delphi method. Results: Eleven preliminary items were generated and submitted to expert evaluation. In the first Delphi round, 10 items reached the consensus threshold, resulting in the exclusion of the delirium item, the merging of two functionality-related items, and the addition of fall risk. In the second round, all remaining items achieved high agreement (Content Validity Index >0.90). The final FisioCan-CP consists of 10 items: functional limitation, immobility syndrome, frailty, moderate/severe pain, asthenia/fatigue, lymphedema, vascular changes, pressure injuries, dyspnea, and fall risk. Conclusion: The FisioCan-CP demonstrated strong content validity and provides an initial, conceptually grounded tool to support physiotherapy referral in palliative care.

Introduction: Chemotherapy applied as a breast cancer treatment may result in chemotherapy-induced peripheral neuropathy (CIPN) as a side effect, encompassing varying degrees of toxicity, according to the employed drug’s pharmacokinetics, administration period, and cumulative dose. In this sense, photobiomodulation employing LASER or LED comprises a safe and non-pharmacological low-cost resource that has been widely studied for the mitigation and even resolution of various oncological comorbidities. The objective of this study is to evaluate the effectiveness of photobiomodulation employing a LED Therapeutic Display (LTD) in the prevention of lower limb CIPN in breast cancer female patients undergoing chemotherapy. Methods: This study encompasses a randomized double-blind superiority clinical trial including women aged 18 and over presenting breast cancer stages I to IIIC with indication for curative treatment applying neoadjuvant or adjuvant chemotherapy. Following recruitment, patients will be allocated into three groups: two intervention groups, which will undergo infrared and red LTD (A) and infrared, red, and violet LTD (B), and a control group (C), which will apply LTD with no light emission. The LTD applications will be conducted at home for 20 minutes daily on each plantar region, until the last day of chemotherapy. All groups will be assessed at the beginning of the chemotherapy treatment, during each cycle, and at the end of the treatment (at 30 days, 3 and 6 months). Lower limb CIPN incidence, pain, body balance, sensitivity, and quality of life will be evaluated, as well as LTD use satisfaction, treatment adherence, and CIPN impacts on daily living activities. Results: This study will evaluate the effectiveness of photobiomodulation employing LTD in preventing lower limb CIPN in Brazilian breast cancer female patients undergoing neoadjuvant or adjuvant chemotherapy. The results will encompass quantitative and self-reported patient data. Conclusions: This study is expected to demonstrate a new prevention modality for this breast cancer treatment complication.

Background Acral melanoma (AM) is a highly aggressive skin cancer associated with high mortality. In this study, we measured inflammatory biomarkers, identified cutoff values, and developed a scoring system to predict mortality in patients with AM. Aims This study aimed to identify inflammatory biomarker cut-off points and factors in AM patients, introducing the Acral Melanoma Inflammatory Risk Index (AMIRI) to predict mortality. Methods In this retrospective cohort study, we analysed 394 patients diagnosed with AM. Demographic and clinicopathological data were obtained from medical records. Inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and absolute neutrophil count (ANC)) were measured at diagnosis. The AMIRI scoring system was used to categorise patients into three risk groups: low (AMIRI ≤ 1), intermediate (1 < AMIRI ≤ 2), and high (AMIRI > 2). We used logistic regression models to evaluate associations between inflammatory markers and mortality. Results The median age of the 394 AM patients was 67 years. The AMIRI scoring system effectively categorised patients into risk groups, with higher scores correlating with increased mortality risk. The Cox model showed a significant increase in 5-year mortality risk for moderate [OR 1.94] and high [OR 1.96] AMIRI risk groups compared to low-risk patients. Limitations This study has limitations, including its retrospective design, being conducted at a single center, incomplete data on adjuvant therapy, and the exclusion of immunotherapy from biomarker analysis, with potential biases from factors like steroid use and associated diseases. Conclusion Inflammatory biomarkers are valuable prognostic tools in AM. The AMIRI scoring system effectively stratifies patients, identifying those with higher mortality risk.

INTRODUCTION:Breast ultrasound is a widely accessible imaging method but highly operator-dependent. Artificial intelligence (AI) may improve breast lesion characterization, aiding in diagnostic decisions. OBJECTIVE:To validate an AI system (Koios DS v3.1) in the BI-RADS classification of breast lesions on ultrasound. METHODS:This cross-sectional diagnostic study included 100 women with breast lesions on ultrasound (July 2022-July 2023), later submitted to histopathology. BI-RADS classifications by conventional ultrasound were compared with AI-based classifications and histopathological findings. Diagnostic agreement and validity measures were calculated. RESULTS:The median patient age was 58.5 years (range, 31-89). AI identified lesions in 93 % of cases. Moderate agreement (Kappa 0.41-0.60) was found between AI and conventional ultrasound BIRADS classification (Kappa = 0.405). When compared with histopathology, AI showed a Kappa of 0.626, with 95.6 % sensitivity, 68.0 % specificity, and a 2.1 % false-negative rate. Disagreement was significantly higher for lesions situated in the lower or central quadrants of the breast (OR = 4.55; p = 0.009) and in irregular heterogeneous areas (OR = 8.27; p < 0.001). CONCLUSION:AI demonstrated high sensitivity and low false-negative rates in classifying breast lesions by ultrasound, showing potential as a complementary diagnostic tool. However, limitations persist, especially in irregular heterogeneous areas and for lesions situated in the lower or central quadrants of the breast.

Introduction: Kinesiophobia has been reported as a determining factor for dysfunction associated with pain and daily living activity alterations in breast cancer patients. This study aimed to identify the frequency and factors associated with kinesiophobia concerning upper limb exercises during the first month after surgery for breast cancer treatment. Methods: Women aged 18 to 79 years with indication for curative breast cancer with an axillary surgery were instructed to perform shoulder exercises with either free or restricted range of motion at home. They returned 30 days after surgery, when kinesiophobia was assessed using the Tampa Scale for Kinesiophobia questionnaire. Results: The study included 298 women. Of these, 64 (21.5%) lost the follow-up, totaling 234 (78.3%) who were assessed for kinesiophobia. Participants with declining functionality and difficulty performing the prescribed exercises worsened 3.19 (95% confidence interval [CI] 0.93 to 5.45; p=0.006) and 2.95 (95%CI 0.30 to 5.41; p=0.019) kinesiophobia score points, respectively, while those who performed professional activities exhibited an improvement of -2.45 (95%CI -4.58 to -0.33) kinesiophobia score points. Conclusion: The breast cancer patients who exhibited poorer functionality and greater difficulty performing the prescribed exercises after surgical treatment exhibited higher kinesiophobia scores, while those who performed professional activities presented lower scores.

PURPOSE:This study aimed to assess the levels of physical activity (PA) and functional capacity of breast cancer patients before and after neoadjuvant chemotherapy. METHODS:The investigation comprises a prospective cohort study including women 18 years or older who underwent neoadjuvant chemotherapy for breast cancer at a single oncology centre between 4 April 2016 and 31 October 2018. Patients were evaluated in terms of self-reported PA levels and physical capacity using the following physical tests: handgrip strength, sitting and standing up in 30 s and stationary walking for 2 min. Variables were compared before and after neoadjuvant chemotherapy using the Wilcoxon test. RESULTS:A total of 440 women were analysed, 88.2% of whom presented at an advanced clinical stage. The mean age of the patients was 51.0 years (±11.0), 68.0% were non-white and 53.9% were not working at the time of diagnosis. Decreased PA levels and handgrip strength (p<0.002) were observed following chemotherapy, although no changes in aerobic capacity and lower limb resistance (LLR) were noted (p=0.595 and p=0.163, respectively). CONCLUSION:Women with breast cancer exhibit decreased PA levels and handgrip strength following neoadjuvant chemotherapy, although no alterations in aerobic capacity and LLR were observed at the end of treatment.

Introduction: Breast cancer is the main cause of cancer death among women in Brazil, accounting for 1 in every 6 deaths. ASCO has developed quality measures on the administration of adjuvant endocrine therapy, radiotherapy and chemotherapy to improve the quality and accessibility of cancer care. We applied these measures to describe the quality of care offered to women with breast cancer in a public hospital in order to identify its determining factors. Methods: Retrospective cohort study of patients diagnosed with breast cancer at the National Cancer Institute (HC III/INCA). Patients treated from April, 2016 to October, 2018, with stages I to III were included. Statistical analyzes were carried out in the Software Statistical Package for the Social Sciences (SPSS®) environment. The association between independent variables and outcome was performed using the crude odds ratio (OR). The variables that presented p<20 in the univariate analysis were included in the multiple logistic regression model using the forward stepwise method, and those with p<0.05 remained in the final model. This study and the respective amendment were approved by the Research Ethics Committee (CEP) of the National Cancer Institute (n°. 1,400,320 and 6,224,883), in accordance with the ethical principles established by the National Health Council. Results: Of the 1556 eligible patients, 590 were excluded. 322 (44.8%) initiated endocrine therapy within 365 days of diagnosis with a median time to initiation of 379 (IQR 278.8-445.5) days. 78 (35.3%) began radiotherapy after breast conserving surgery within 365 days of diagnosis with time mean to start this treatment of 430 (SD ±140.4) days. Regarding women with hormone receptor-negative breast cancer, 9 (100%) received chemotherapy after 120 days from diagnosis. After adjustment, age >60 (OR 1.49; IC95% 1.6-2.9; p<0.001 and OR 2.74; IC95% 1.42 - 5.28; p<0.003) and locally advanced staging (OR 4.03; IC95% 2.89 - 5.62; p<0.001 and OR 13.47; IC95% 3.05 - 59.44; p<0.001) were predictors non-concordance with endocrine therapy and radiotherapy, respectively. On the other hand, Luminal A-like tumors had a greater chance of agreement with the start of hormone therapy and radiotherapy before 365 days after diagnosis (OR 0.40; IC95% 0.27-058; p<0.021 and OR 0.22; IC95% 0.11-0.46; p<0.03). Patients who underwent adjuvant radiotherapy had a greater chance of not starting treatment with hormone therapy within 365 days. (OR 1.69; IC95% 1.14-2.50; p<0.009). Conclusion: We described breast cancer care in a major Brazilian institution underperforming the quality measurements suggested by ASCO. Age over 60, advanced staging and adjuvant radiotherapy were predictors of non-agreement while Luminal A-like tumors increased the chance of measurement agreement. The measures were informative about the quality of public care, making it possible to identify determining factors that interfere with the provision of high-quality care. Citation Format: Anne Dominique Nascimento Lima, Suzana Sales de Aguiar, Anke Bergmann, José Bines, Luiz Claudio Santos Thuler. Determinants for concordance of ASCO quality of care measures in women with breast cancer in a Brazilian cohort [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P3-05-13.