Archaeologists, as well as specialists and practitioners in cultural heritage, require applications with additional functions, such as the annotation and attachment of metadata to specific regions of the 3D digital artifacts, to go beyond the simplistic three-dimensional (3D) visualization. Different strategies addressed this issue, most of which are excellent in their particular area of application, but their capacity is limited to their design's purpose; they lack generalization and interoperability. This paper introduces ART3mis, a general-purpose, user-friendly, feature-rich, interactive web-based textual annotation tool for 3D objects. Moreover, it enables the communication, distribution, and reuse of information as it complies with the W3C Web Annotation Data Model. It is primarily designed to help cultural heritage conservators, restorers, and curators who lack technical expertise in 3D imaging and graphics, handle, segment, and annotate 3D digital replicas of artifacts with ease.

We propose a novel point cloud U-Net diffusion architecture for 3-D generative modeling capable of generating high-quality and diverse 3-D shapes while maintaining fast generation times. Our network employs a dual-branch architecture, combining the high-resolution representations of points with the computational efficiency of sparse voxels. Our fastest variant outperforms all nondiffusion generative approaches on unconditional shape generation, the most popular benchmark for evaluating point cloud generative models, while our largest model achieves state-of-the-art results among diffusion methods, with a runtime approximately 70% of the previously state-of-the-art point-voxel diffusion (PVD), measured on the same hardware setting. Beyond unconditional generation, we perform extensive evaluations, including conditional generation on all categories of ShapeNet, demonstrating the scalability of our model to larger datasets, and implicit generation, which allows our network to produce high-quality point clouds on fewer timesteps, further decreasing the generation time. Finally, we evaluate the architecture’s performance in point cloud completion and super-resolution. Our model excels in all tasks, establishing it as a state-of-the-art diffusion U-Net for point cloud generative modeling. The code is publicly available at https://github.com/JohnRomanelis/SPVD

Human milk is a complex and highly organized biofluid whose molecular composition underpins neonatal nutrition, immune protection, and developmental regulation. Despite extensive proteomic profiling, its global organizational structure remains fragmented and poorly integrated. Here, we performed a large-scale meta-analysis of mass spectrometry-based proteomics datasets to construct a unified, queryable human milk proteome atlas for system-level interpretation. By harmonizing datasets through standardized preprocessing and normalization, we defined a core human milk proteome comprising the most recurrent and consistently detected proteins and peptides. An established machine-learning-based method was applied to predict binary protein-protein interactions from this core set, enabling reconstruction of a dense interaction network and moving beyond isolated protein catalogues toward a systems-level representation of milk organization. Network analysis revealed functional modules related to immune defence, vesicle-mediated secretion, and proteostatic control, while protein regulatory networks were also reconstructed. These results highlight the systems-level relevance of milk proteins and their potential role in maternal-infant regulation in health and disease. The integrative framework and web resource (http://atlas-galatea.insybio.com/) provide a foundation for comparative proteomics and network-based studies of the regulatory architecture of human milk.

Climate change and soil degradation pose a challenge to grape quality, motivating the development of integrated monitoring approaches combining soil analysis with remote sensing techniques. However, harmonized information addressing this multidisciplinary challenge remains scarce. Therefore, this systematic review synthesizes the scientific literature published since 2020 with the aim of (i) identifying key soil properties and techniques applied, (ii) evaluating remote sensing approaches and their integration with soil data, and (iii) highlighting knowledge gaps and challenges for sustainable precision viticulture. A search in Scopus yielded 197 full-text articles classified into three thematic groups and analyzed using a standardized extraction protocol. Our synthesis reveals that pH, electrical conductivity, soil organic matter, and cation exchange capacity are the most consistently reported physicochemical parameters across the reviewed studies, while next-generation sequencing and multi-omics approaches are increasingly adopted in microbiological research to characterize rhizosphere communities and their links to terroir expression. In remote sensing, multispectral UAV platforms and satellite missions (Sentinel-2, Landsat) combined with vegetation indices, principally NDVI, dominate the toolset for monitoring vine vigor and water status. Nevertheless, genuine integration of remote-sensing outputs with root-zone soil measurements remains uncommon, with most studies treating both data streams independently. The principal knowledge gaps identified concern the absence of standardized sustainability assessment frameworks, limited cross-terroir transferability of predictive models, and insufficient long-term multi-site datasets to underpin climate change adaptation in vineyard management.

In this paper we study the problem of shape part retrieval in the point cloud domain. Shape retrieval methods in the literature rely on the presence of an existing query object, but what if the part we are looking for is not available? We present Part Retrieval Pipeline (PReP), a pipeline that creatively utilizes metric learning techniques along with a trained classification model to measure the suitability of potential replacement parts from a database, as part of an application scenario targeting circular economy. Through an innovative training procedure with increasing difficulty, it is able to learn to recognize suitable parts relying only on shape context. Thanks to its low parameter size and computational requirements, it can be used to sort through a warehouse of potentially tens of thousand of spare parts in just a few seconds. We also establish an alternative baseline approach to compare against, and extensively document the unique challenges associated with this task, as well as identify the design choices to solve them.

Beyond simplistic 3D visualisations, archaeologists, as well as cultural heritage experts and practitioners, need applications with advanced functionalities. Such as the annotation and attachment of metadata onto particular regions of the 3D digital objects. Various approaches have been presented to tackle this challenge, most of which achieve excellent results in the domain of their application. However, they are often confined to that specific domain and particular problem. In this paper, we present ART3mis - a general-purpose, user-friendly, interactive textual annotation tool for 3D objects. Primarily attuned to aid cultural heritage conservators, restorers and curators with no technical skills in 3D imaging and graphics, the tool allows for the easy handling, segmenting and annotating of 3D digital replicas of artefacts. ART3mis applies a user-driven, direct-on-surface approach. It can handle detailed 3D cultural objects in real-time and store textual annotations for multiple complex regions in JSON data format.

Digital Twins (DTs) are quickly becoming popular in multiple application domains, from industrial production environments to cultural heritage sites and smart cities. In this landscape, DTs for educational buildings offer a promising approach towards achieving energy efficiency, circularity and sustainability, and an important new smart city application domain, among other aspects. While there have been recent examples of DTs for university campuses, examples for primary and secondary school buildings are few and far between. In this work, we present our implementation of a DT for two secondary education buildings in Greece, involving IoT infrastructure, 3D digitization, data analytics, energy modeling, 3D annotation and segmentation, while discussing its potential application within several scenarios. We also discuss a number of the aspects related to educational building DTs. Overall, such DTs can offer several new application opportunities to the smart city community.

The Internet of Things (IoT) plays a major role today in smart building infrastructures, from simple smart-home applications, to more sophisticated industrial type installations. The vast amounts of data generated from relevant systems can be processed in different ways revealing important information. This is especially true in the era of edge computing, when advanced data analysis and decision-making is gradually moving to the edge of the network where devices are generally characterised by low computing resources. In this context, one of the emerging main challenges is related to maintaining data analysis accuracy even with less data that can be efficiently handled by low resource devices. The present work focuses on correlation analysis of data retrieved from a pilot IoT network installation monitoring a small smart office by means of environmental and energy consumption sensors. The research motivation was to find statistical correlation between the monitoring variables that will allow the use of machine learning (ML) prediction algorithms for energy consumption reducing input parameters. For this to happen, a series of hypothesis tests for the correlation of three different environmental variables with the energy consumption were carried out. A total of ninety tests were performed, thirty for each pair of variables. In these tests, p-values showed the existence of strong or semi-strong correlation with two environmental variables, and of a weak correlation with a third one. Using the proposed methodology, we manage without examining the entire data set to exclude weak correlated variables while keeping the same score of accuracy.

In the cadre of the Industry 4.0 initiative, and its proposed RAMI 4.0 reference architecture, the Asset Administration Shell (AAS) is gaining traction in the industrial sector, ushering production practices to new precedents and enabling the incorporation of the latest digital technologies. However, the task of instigating the new era of industry is not without difficulties. The current work performs a systematic literature review of AAS by thoroughly reviewing 86 recently published journal articles. The aim is to put in scope current use cases of the AAS, categorise them and, thus, paint a comprehensive picture of AAS usage, by synthesizing all recent journal literature. The second part of the work focuses on highlighting current challenges that appear at the intersection of AAS with necessities of the industrial sector, as well as with the AAS’s integration with novel concepts and technologies.

Today, technology and sustainability are two strategic axes for the development of any industry. Art is no exception and embodies both principles. Artificial intelligence (AI) is driving the art world forwards with its applications and algorithms. Additionally, the circular economy (CE) is concerned with resources and the environment in this context. The objective of the present work is to provide an overview of the current state of research on the application of AI in the art world and an analysis of how CE principles are being incorporated, considering the interactions between AI and the CE. To this end, a systematic review of the literature is carried out in which 60 articles related to the subject are selected, analysed, and classified, highlighting the lines of research addressed. The assessment of the current state of research on the subject concludes with the four main axes of classification of works. The first line is related to AI generative content in art, addressing issues of content creation, image and painting, video, and theatre. The second line is related to AI applications for art industry production, considering the sustainability of the supply chain. The third line focuses on how the CE is being applied to art, while the fourth line focuses on other relevant aspects analysed, such as training and design. The topic is still incipient, mandating further research to study the full potential of AI and the CE in the world of art.

Protein residues within binding pockets play a critical role in determining the range of ligands that can interact with a protein, influencing its structure and function. Identifying structural similarities in proteins offers valuable insights into their function and activation mechanisms, aiding in predicting protein–ligand interactions, anticipating off-target effects, and facilitating the development of therapeutic agents. Numerous computational methods assessing global or local similarity in protein cavities have emerged, but their utilization is impeded by complexity, impractical automation for amino acid pattern searches, and an inability to evaluate the dynamics of scrutinized protein–ligand systems. Here, we present a general, automatic and unbiased computational pipeline, named VirtuousPocketome , aimed at screening huge databases of proteins for similar binding pockets starting from an interested protein–ligand complex. We demonstrate the pipeline's potential by exploring a recently-solved human bitter taste receptor, i.e. the TAS2R46, complexed with strychnine. We pinpointed 145 proteins sharing similar binding sites compared to the analysed bitter taste receptor and the enrichment analysis highlighted the related biological processes, molecular functions and cellular components. This work represents the foundation for future studies aimed at understanding the effective role of tastants outside the gustatory system: this could pave the way towards the rationalization of the diet as a supplement to standard pharmacological treatments and the design of novel tastants-inspired compounds to target other proteins involved in specific diseases or disorders. The proposed pipeline is publicly accessible, can be applied to any protein–ligand complex, and could be expanded to screen any database of protein structures.

Smart cities have been a very active research area in the past 20 years, while continuously adapting to new technological advancements and keeping up with the times regarding sustainability and climate change. In this context, there have been numerous proposals to expand the scope of smart cities, focusing on resilience and sustainability, among other aspects, resulting in terms like smart sustainable cities. At the same time, there is an ongoing discussion regarding the degree in which smart cities put people at their centre. In this work, we argue toward expanding the current smart city definition by integrating the circular economy as one of its central pillars and adopting the term smart (and) circular city. We discuss the ways a smart and circular city encompasses both sustainability and smartness in an integral manner, while also being well-positioned to foster novel business activity and models and helping to place citizens at the heart of the smart city. In this sense, we also argue that previous research in smart cities and technologies, such as those related to Industry 4.0, can serve as a cornerstone to implement circular economy activities within cities, at a scale that exceeds current activities that are based on more conventional approaches. We also outline current open challenges in this domain and research questions that still need to be addressed.

Food and nutrition are a steadfast essential to all living organisms. With specific reference to humans, the sufficient and efficient supply of food is a challenge as the world population continues to grow. Artificial Intelligence (AI) could be identified as a plausible technology in this 5th industrial revolution in bringing us closer to achieving zero hunger by 2030—Goal 2 of the United Nations Sustainable Development Goals (UNSDG). This goal cannot be achieved unless the digital divide among developed and underdeveloped countries is addressed. Nevertheless, developing and underdeveloped regions fall behind in economic resources; however, they harbor untapped potential to effectively address the impending demands posed by the soaring world population. Therefore, this study explores the in-depth potential of AI in the agriculture sector for developing and under-developed countries. Similarly, it aims to emphasize the proven efficiency and spin-off applications of AI in the advancement of agriculture. Currently, AI is being utilized in various spheres of agriculture, including but not limited to crop surveillance, irrigation management, disease identification, fertilization practices, task automation, image manipulation, data processing, yield forecasting, supply chain optimization, implementation of decision support system (DSS), weed control, and the enhancement of resource utilization. Whereas AI supports food safety and security by ensuring higher crop yields that are acquired by harnessing the potential of multi-temporal remote sensing (RS) techniques to accurately discern diverse crop phenotypes, monitor land cover dynamics, assess variations in soil organic matter, predict soil moisture levels, conduct plant biomass modeling, and enable comprehensive crop monitoring. The present study identifies various challenges, including financial, infrastructure, experts, data availability, customization, regulatory framework, cultural norms and attitudes, access to market, and interdisciplinary collaboration, in the adoption of AI for developing nations with their subsequent remedies. The identification of challenges and opportunities in the implementation of AI could ignite further research and actions in these regions; thereby supporting sustainable development.

Agriculture is an essential industry that plays a crucial role in global food security. In recent years, blockchain technology has emerged as a transformative tool with the potential to improve efficiency, transparency and sustainability in various industries. This article explores the specific applications of blockchain technology in the agricultural sector and how it can contribute to overcoming key challenges, such as traceability, supply chain management and facilitating secure transactions. This review is part of the research carried out in the European H2020 project, SUSTAINABLE, whose strategic objective is to test and validate new state of the art Artificial Intelligence (AI) systems as decision support systems (DSS), on a sound economic and technical basis, for appropriate management procedures in precision agriculture depending on specific climatic, geographical and environmental conditions.

Taste perception plays a pivotal role in guiding nutrient intake and aiding in the avoidance of potentially harmful substances through five basic tastes - sweet, bitter, umami, salty, and sour. Taste perception originates from molecular interactions in the oral cavity between taste receptors and chemical tastants. Hence, the recognition of taste receptors and the subsequent perception of taste heavily rely on the physicochemical properties of food ingredients. In recent years, several advances have been made towards the development of machine learning-based algorithms to classify chemical compounds' tastes using their molecular structures. Despite the great efforts, there remains significant room for improvement in developing multi-class models to predict the entire spectrum of basic tastes. Here, we present a multi-class predictor aimed at distinguishing bitter, sweet, and umami, from other taste sensations. The development of a multi-class taste predictor paves the way for a comprehensive understanding of the chemical attributes associated with each fundamental taste. It also opens the potential for integration into the evolving realm of multi-sensory perception, which encompasses visual, tactile, and olfactory sensations to holistically characterize flavour perception. This concept holds promise for introducing innovative methodologies in the rational design of foods, including pre-determining specific tastes and engineering complementary diets to augment traditional pharmacological treatments.

Taste perception plays a pivotal role in guiding nutrient intake and aiding in the avoidance of potentially harmful substances through five basic tastes - sweet, bitter, umami, salty, and sour. Taste perception originates from molecular interactions in the oral cavity between taste receptors and chemical tastants. Hence, the recognition of taste receptors and the subsequent perception of taste heavily rely on the physicochemical properties of food ingredients. In recent years, several advances have been made towards the development of machine learning-based algorithms to classify chemical compounds' tastes using their molecular structures. Despite the great efforts, there remains significant room for improvement by developing multi-class models to predict the entire spectrum of basic tastes. Here, we present a multi-class predictor aimed at distinguishing three different tastes, i.e., bitter, sweet, and umami, from other taste sensations. The developed model has been integrated into a publicly accessible web platform. This work lays the groundwork for a comprehensive understanding of the molecular features that drive the perception of tastes, paving the way towards new methodologies in the rational design of foods, such as the pre-determination of specific tastes, the engineering of complementary diets to traditional pharmacological treatments, and many others.

As the global population continues to increase, projected to reach an estimated 9.7 billion people by 2050, there will be a growing demand for food production and agricultural resources. Transition toward Agriculture 4.0 is expected to enhance agricultural productivity through the integration of advanced technologies, increase resource efficiency, ensure long-term food security by applying more sustainable farming practices, and enhance resilience and climate change adaptation. By integrating technologies such as ground IoT sensing and remote sensing, via both satellite and Unmanned Aerial Vehicles (UAVs), and exploiting data fusion and data analytics, farming can make the transition to a more efficient, productive, and sustainable paradigm. The present work performs a systematic literature review (SLR), identifying the challenges associated with UAV, Satellite, and Ground Sensing in their application in agriculture, comparing them and discussing their complementary use to facilitate Precision Agriculture (PA) and transition to Agriculture 4.0.

Monitoring noise pollution in urban areas in a more systematic manner has been gaining traction as a theme among the research community, especially with the rise of smart cities and the IoT. However, although it affects our everyday life in a profound way, monitoring indoor noise levels inside workplaces and public buildings has so far grabbed less of our attention. In this work, we report on noise levels data produced by an IoT infrastructure installed inside 5 school buildings in Greece. Our results indicate that such data can help to produce a more accurate picture of the conditions that students and educators experience every day, and also provide useful insights in terms of health risks and aural comfort.

Cyber-physical systems help toward mitigating the impact of climate change on cultural heritage sites and monuments by utilizing cultural heritage digital twins, coupled with artificial intelligence/machine learning algorithms, facilitating degradation detection and triggering appropriate actions.