The alarmin cytokine IL-33 stimulates the formation of immune hubs within otherwise “cold” tumors.

Peptidergic nociceptors promote gastric cancer through the release of the neuropeptide CGRP.

Glutamate is required for macrophage-driven liver regeneration.

Glutamate is required for macrophage-driven liver regeneration.

The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.

ATP released by osteoblasts signals through the purinergic receptor P2RX4 to optimize plasma cell survival.

Apoptosis of immature peripheral B cells may be due to a lack of survival signals rather than clonal deletion.

Early exposure to cholesterol primes later atherosclerosis through phenotypic changes to resident-like arterial macrophages.

Prostaglandins in the tumor microenvironment block IL-2–induced expansion of killer T cells.

Microglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner.

Inflammasome activation by circulating DNA leads to recurrent stroke associated with atherosclerosis.

Secreted factors from pyroptotic cells can promote wound repair.

Apoptosis of immature peripheral B cells may be due to a lack of survival signals rather than clonal deletion.

A neuropeptide-receptor pair promotes the differentiation of T H 1 cells and enhances their response to viral infection.

Apoptosis of immature peripheral B cells may be due to a lack of survival signals rather than clonal deletion.

Apoptosis of immature peripheral B cells may be due to a lack of survival signals rather than clonal deletion.

Interferon-ε has antitumor activity and activates antitumor immunity in ovarian cancer in mice.

Loss of phosphatidylinositol transfer protein alpha underlies pancreatic β cell failure.

STING activity in cancer cells prevents the progression of dormant metastasis.

The noncanonical caspase caspase-4 processes the pro form of IL-18 in response to LPS.