目的：探讨金花茶对亚急性衰老大鼠抗氧化和抗凋亡的作用。方法拟建立大鼠亚急性衰老模型后，予高、低浓度金花茶灌胃干预。测肝脏和睾丸组织超氧化物歧化酶（SOD），丙二醛（MDA）含量及 bax、bcl－2 mRNA 表达水平。结果与衰老模型组对比，高、低浓度金花茶组肝脏和睾丸组织 SOD 含量和 bcl－2 mRNA 表达显著升高（P＜0．05），且 MDA 含量和 bax mRNA 表达明显下降（P＜0．05）。高、低浓度金花茶组间比较，上述指标有统计学差异（P＜0．05）。结结论金花茶可以提高 SOD 含量和降低 MDA 含量，通过上调 bcl－2和下调 bax 表达水平，减慢肝脏和睾丸细胞的凋亡，对延缓机体衰老有重要作用。

Aim To investigate whether the Camellia chrysantha(Hu) Tuyama can improve lipid metabolism and decrease hepatic apoptosis in aging rats. Methods Forty healthy male SD rats were recruited and divided into two groups randomly as follow: group 1 is normal control,group 2 to group 4 was subacute aging model induced by subcutaneous injection with D-galactose.Group 3 and 4 were treated with high/low Camellia chrysantha concentration respectively,meanwhile the group 2 was treated with saline as the control.Assay the levels of serum lipid in tail vein including the triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDLC) and high density lipoprotein cholesterol(HDLC).Test liver issue content of TC,TG,and the level of mRNA expression of Bcl-2 and Bax. Results Compared with the control group,serum HDLC level and Bcl-2 expression level of the treatment group increased significantly,while serum TC,TG,LDLC content as well as the TC,TG,Bax expression levels associated with the liver tissues declined markedly(P<0.05).These indicators still exhibited significant difference with comparison between high and low Camellia chrysantha(Hu) Tuyama groups(P<0.05). Conclusions Camellia chrysantha can improve lipid metabolism,reduce fataccumulation in liver which may decrease the hepatic apoptosis in aging rats,to reduce the risk of atherosclerosis.