Objective To study the clinical manifestation and neuroimaging findings and further to pro ve the etiology of nonspecific inflammation of Tolosa-Hunt syndrome(THS). Methods The clinical manifestation,pathological,neuroimaging a nd pathological data of such 28 cases hospitalized from May 1985 to October 2000 and literatures were retrospectively reviewed. Results The type,the site and t he severity of the headache were shown greatly different individually. The relapse often occurred.The number of the involved cranial nerves varied from 1 to 5 branches.The treatment using corticosteroid was effective but some of th e m were resulting in cranial nerve paralysis. One was operation case in which t h e histologic study showed a number of lymphocytes,plasmocytes and collagenous f ibers,but no tumor cells. Pathological diagnosis showed an inflammatory granu l oma. Neuroimaging examinations: CT scans in 6 of 27 showed cavernous sinus lesi o n (CSL).MRI scans in 12 of 21 cases showed CSL.DSA in 5 of 12 showed CSL. Fol low -up Eexaminations: CT and MRI in 4 of 12 having negative results in the first time examination showed CSL. The CSL both in CT and MRI in 10 of 12 having posi t ive results by the first time examination had obviously diminished or disappeare d. The CSL both in CT and MRI were homogeneously well-enhanced. Co nclusions T he study showed that,the etiology of nonspecific inflammation was supported again . In this article the follow-up study both on clinical and neuroimaging examinat i ons for those atypical and not completely recovered was carried out as to maki ng sure the etiology and further therapy.