This study evaluated the diagnostic and prognostic value of serum bone metabolism markers—osteocalcin and β-Cross-Laps—in patients with type 2 diabetes mellitus (T2DM) undergoing intraosseous dental implantation. A blind randomized prospective clinical study was conducted between 2023 and 2025 involving 73 patients with partial or complete edentulism. Patients were randomly assigned to two groups: (1) Group A: 37 patients received UV-photofunctionalized implants (154 implants). (2) Group B: 36 patients received non-UV-photofunctionalized implants (148 implants). Serum osteocalcin and β-Cross-Laps were measured preoperatively, 1 month postoperatively, and 3 months after implantation using enzyme-linked immunosorbent assay (ELISA). Clinical and radiological outcomes included implant survival, marginal bone loss (MBL), probing pocket depth (PPD), bleeding on probing (BOP), resonance frequency analysis (RFA), and prosthetic success. Significant correlations were observed between serum osteocalcin and β-Cross-Laps concentrations and implant success rates. Implant failure occurred more frequently in patients with low osteocalcin and elevated β-Cross-Laps. Implant survival over 3 years was 95.2

To study the effectiveness of combined treatment in patients with dry socket, (alveolar osteitis) after tooth extraction. The 86 patients with alveolar osteitis (50 females − 58

Purpose of this study was to evaluate the distribution of bone tension around single implants with different С/I ratio (1.5:1, 1.75:1, 2:1) according to the von Mises criterion. Stress analysis was performed using Invesalius 3.0, Rhinoceros 3D 4.0 software. Three 3D models of the mandibular segment of the bone block were developed: model A, a short implant (6 mm) C/I -1.5:1; model B, a short implant (6 mm) C/I -1.75:1; model C, a short implant (6 mm) C/I -2:1. The results were evaluated: the cumulative frequency of implant engraftment, MBL changes around the implant, follow up for 5 years. Under axial load, the highest stresses were concentrated at the abutment/implant junctions, the highest stresses were 67.94 MPa C/I -1.5:1, 68.09 MPa C/I -1.75:1 and 68.24 MPa C/ I -2:1, respectively. The results of the current study, indicate the increase in crown height showed little difference in load at the crown/implant interface with crown/implant ratios of 1.5:1, 1.75:1 and 2:1. In vivo finite element analysis (FEA) study showed that short implantats are successful regardless the C/I ratio. Use of shorts implants for prosthetic rehabilitation can be considered favorable and well substantiated.

To evaluate the influence of crown-to-implant ratio(C/I) on marginal bone level changes and survival rate of implants during function. The study included 68 patients with completely or partial edentulous and severe vertical bone atrophy, which were restored with a single crown(46) or a partial fixed(48) denture supported by 152 short implants. Implants were divided into three groups according to the C/I ratio (1.5:1, 1,75:1, 2:1). The results were evaluated: failures of the implant, any complications, implants marginal bone loss (MBL), implants success rates the follow up for 5 years. MBL was assessed by taking x-rays after restoration fixation, after 1,3,5 years post operatively. During implantation and in the post-implantation period, no serious biological or prosthetic complications were recorded. After 1 years in Group 1 mean MBL 0.86 ± 0.4 mm, after 3 years 0,98 ± 0.2 mm), after 5 years 1.05 ± 0.3 mm. After 1 years in Group 2 mean MBL 0.97 ± 0.3 mm, after 3 years 1,07 ± 0.4 mm), after 5 years MBL was 1.12 ± 0.6 mm.Аfter 1 years in Group 3 mean MBL 1,08 ± 0.6 mm, after 3 years 1,19 ± 0.2 mm, after 5 years MBL was 1.27 ± 0.3 mm. Short implants cumulative success of implantation after 5 years was 97.8

The purpose of this study is to evaluate the effect of ultraviolet UV photo functionalization on the antimicrobial properties in implants installed in patients with type 2 diabetes mellitus. The study included 74 patients with diabetes with unilateral/bilateral missing teeth (aged 36 to 63 years). The participants were randomly divided into 2 groups; Group-A included 38 patients with UV photo functionalized 204 implants and Group-B included 36 patients with non UV photo functionalized 183 implants. The clinical parameters of the dental implants were evaluated by assessing PD, BOP, MBL 6 months, 12 months, and 3 years after implant installation, compared with values at last follow-up. Concentrations of interleukin IL-1β and TNF-α cytokines in blood serum were evaluated using enzyme-linked immunosorbent assay. After implant surgery, the patients in Group-A had minimal postoperative reactions including swelling, discoloration, discomfort, hematomas. After implant surgery, the patients in Group-B had a mild postoperative reaction including swelling and discomfort. Preoperative serum IL-1β levels and TNF-α in Group-A and Group-B patients did not differ significantly. After implant surgery indicators of cytokines markers show correlation with Group-A and Group-B, the rates of IL-1β levels and TNF-α are higher in patients of Group-B. Analysis of the results showed the greatest increase in the rates of IL-1β levels and TNF-α in peri-mucositis and peri-implantitis. The survival rate of implants in Group A patients is 97.3% and in Group B patients is 94.2% after five-years. The results of the study showed that monitoring levels of the cytokines TNF-α and IL-1β may aid in the early diagnosis of peri-implantitis and prognosis in high-risk patients with type 2 diabetes mellitus.

Abstract Background Late detection of malignant neoplasms in the maxillofacial region indicates diagnostic deficiencies. The relevance of this problem indicates the need to improve diagnostic and prevention methods and increase the level of “oncological alertness” of both doctors and patients themselves. Objectives The objective of this review is to evaluate role of diagnostic advanced methods for detecting oral and maxillofacial neoplasms at the earliest stages. Methodology Comprehensive search strategy. The systematic review included articles from Google Scholar, Medline, Scopus, Web of Sciences, PubMed was conducted to identify articles used for the diagnostic evaluation of head and neck cancer. 181 articles were found and, 110 articles of high methodological quality were selected for the synthesis of cancer diagnostics according to the review method used, the PRISMA. Two reviewer (DM,GH) authors screened the results of the searches against inclusion criteria, extracted data and assessed risk of bias independently and in duplicate. Inclusion criteria: Trials were selected if they met the following mesh criteria: design—random assignment of participants; participants—any cancer patient undergoing surgery, chemotherapy or radiation therapy for cancer; diagnostics—toluidine blue staining, light detection methods chemiluminescence, fluorescence scintigography, ultrasound, X-rays, CT, MRI, positron emission tomography (PET), tumor marker, biopsy and/or histopathological evaluation written in English articles. There was no limitation on minimal quality, minimal sample size, or the number of patients. Exclusion criteria were: Unpublished studies, conference abstracts, letters to the editor, case reports, in vitro and in vivo animal experimental studies to reduce publication bias. The effectiveness was evaluated by synthesizing relevant outcome data extracted from selected studies. Results The review describes modern achievements in methods for diagnosing tumors in the oral cavity and maxillofacial area. The most advanced methods are MRI, PET, tumor marker, immunohistopathological diagnostics. The results of the review can help improve the efficiency of cancer diagnosis and preventive complications in cancer patients. The relevance of this problem indicates the need to improve diagnostic and prevention methods, increase the level of “oncological alertness” of both doctors and patients themselves. Conclusions The clinical and economic significance of early diagnosis and selection of the optimal treatment method for cancer patients determines the need to introduce the latest methods of cancer diagnosis, including analysis of the results of diagnostics.

The aim of the study is to compare the clinical efficacy of the application of "Armenicum" paste as an adjunct to SRP for the non‐surgical treatment of patients with periodontitis. The current RCT prospective study was conducted on 157 patients with chronic periodontitis. The patients were blind randomly assigned into two groups: Group A (SRP + Armenicum" paste) 81 patients (42 males and 39 females, 37 to 68 years) and Group B (SRP) 76 patients (39 males and 37 females, 37 to 68 years). Periodontal indices BOP, PPD, and DPI within each treatment group were measured before periodontal therapy, 3 and 6 months after the treatment. Group A underwent a periodontal treatment which included: supragingival and subgingival scaling, and additional use of local "Armenicum" paste. The Group B group only received supragingival and subgingival scaling. In our study, the mean BOP, DPI, and PPD showed a statistically significant difference from baseline to 3 months and 6 months (p ≤ 0.05) in both Group A and Group B. But, mean BOP and mean PPD reduction gain was found to be greater in Group-A than Group B at 3 months and 6 months. No statistical differences in clinical indices were recorded depending on gender and age. These results indicate that topical "Armenicum" paste provides an effective adjunctive treatment of chronic periodontitis. The results of the current study showed that the adjunctive use of "Armenicum" reduced signs of inflammation compared to standard SRP treatment alone. Periodontal therapy using Armenicum paste application can be considered as a promising method in the treatment of periodontitis.

The absence of an intact auricle can lead to both functional impairments and psychological distress, prompting individuals to withdraw from social interactions. Consequently, there is a pressing need for functional and aesthetic rehabilitation in these patients to restore their psychosocial well-being. When surgical reconstruction is not optimal, an auricular prosthesis can be fabricated and fixed with glue to the skin or with a magnetic fixation on osteointegrated implants. This comparative study aims to evaluate the efficacy of auricle defect restoration using prostheses with adhesive fixation to the skin and magnetic fixation on implants inserted into the mastoid processes. Fourteen patients (eight men and six women, average age 42 years) were included in the study. Among them, 12 patients had unilateral auricle defects, while two patients presented bilateral defects. The causes of auricle defects were predominantly traumatic (12 cases), with two cases attributed to congenital factors. Patients were stratified into two groups: Group 1, comprised six patients, in whom the auricular prosthesis was fixated to the skin using a biological adhesive (glue) and Group 2 consisted of eight patients, in whom the auricular prosthesis was retention osseointegrated implants inserted into the mastoid processes of the temporal bone. In Group 2, five cases were rehabilitated with prostheses featuring magnetic fixation, while the remaining three cases utilized prostheses with attachment fixation. During the observation period ranging from six months to three years, none of the patients in group 2 encountered implant-related issues such as poor osseointegration or wound healing complications. Overall, all patients expressed satisfaction with the treatment outcomes, citing the relatively short hospital stay and less invasive nature of the procedure compared to alternative treatments. Implant-retained auricular prostheses present a favorable treatment option characterized by excellent retention and high patient satisfaction. In contrast, prostheses fixed with adhesives pose several drawbacks, including skin irritation, dermatitis, and the potential for deformation of the auricular prostheses, presenting significant challenges for both patients and clinicians. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Evaluation of the effectiveness Gengigel® Oral Gel (hyaluronic acid ) and photobiomodulation (magnetic laser) in the treatment of alveolar osteitis in patients with type 2 diabetes mellitus. This is a blind RCT study clinical prospective study in 69 patients with type 2 diabetes mellitus with alveolar osteitis. The subjects selected for study were examined under the inclusion and exclusion criteria and sign the written consent. The patients were blind randomly assigned into two groups: The Group I included 35 patients with alveolar osteitis, in which complex treatment including HA and magnetic laser therapy was carried out. The Group II is represented by 34 patients, with alveolar osteitis received treatment including antiseptic and inflammatory agents. Healing time and pain levels of the alveolar socket of the extracted tooth were appreciated. The pain levels in dynamics were assessed according to VAS. After the 5th treatment session, 91

Background: The overall aesthetics of the face are significantly affected by the appearance of the nose. Among the nasal defects, the saddle type of nose is often found. Various grafting materials are widely used in rhinoplasty. However, the choice of the optimal material in different clinical situations remains a matter of debate. Purpose: The purpose of this review was to evaluate effects various grafting materials used in rhinoplasty advantages and disadvantages of each. Methods: The review included articles from Google Scholar, Medline, Scopus, Web of Sciences, PubMed, Cochrane Library websites were searched. Saddle type of nose, rhinoplasty autograft, (septal cartilage, auricular cartilage, costal cartilage), allograft, PRP, fluid cartilage, rhinofiller and alloplastic implants, were used as search keywords; the effectiveness of the use of each material, resorption results, complications, functional and aesthetic satisfaction of patients were evaluated. Review was conducted according to the PRISMA guidelines. Results: Out of 127 articles in the literature search, 71 articles that met the inclusion criteria were included in this article. Autograft is very applicable in dorsal rhinoplasty, but autograft surgery of autograft cartilage is not acceptable for all patients in all cases, due to various complications that may occur at the donor site, such as pain, pneumothorax, and scarring. An alternative is allograft (irradiated and non-irradiated rib) which excludes the above-mentioned complications, but has a higher resorption rate; Currently used alloplastic materials also have drawbacks and scientific research in the optimal direction is ongoing. Conclusions: With this comprehensive review, the authors hope to highlight the advantages and disadvantages of the different materials currently used in aesthetic rhinoplasty, which may enable the surgeon to achieve optimal aesthetic and functional results. Further research is needed to establish clear guidelines for selecting the appropriate material for rhinoplasty.

Late detection of malignant neoplasms in the maxillofacial region indicates diagnostic deficiencies. The relevance of this problem indicates the need to improve diagnostic and prevention methods and increase the level of “oncological alertness” of both doctors and patients themselves. The objective of this review is to evaluate role of diagnostic advanced methods for detecting oral and maxillofacial neoplasms at the earliest stages. Comprehensive search strategy. The systematic review included articles from Google Scholar, Medline, Scopus, Web of Sciences, PubMed was conducted to identify articles used for the diagnostic evaluation of head and neck cancer. 181 articles were found and, 110 articles of high methodological quality were selected for the synthesis of cancer diagnostics according to the review method used, the PRISMA. Two reviewer (DM,GH) authors screened the results of the searches against inclusion criteria, extracted data and assessed risk of bias independently and in duplicate. Inclusion criteria: Trials were selected if they met the following mesh criteria: design—random assignment of participants; participants—any cancer patient undergoing surgery, chemotherapy or radiation therapy for cancer; diagnostics—toluidine blue staining, light detection methods chemiluminescence, fluorescence scintigography, ultrasound, X-rays, CT, MRI, positron emission tomography (PET), tumor marker, biopsy and/or histopathological evaluation written in English articles. There was no limitation on minimal quality, minimal sample size, or the number of patients. Exclusion criteria were: Unpublished studies, conference abstracts, letters to the editor, case reports, in vitro and in vivo animal experimental studies to reduce publication bias. The effectiveness was evaluated by synthesizing relevant outcome data extracted from selected studies. The review describes modern achievements in methods for diagnosing tumors in the oral cavity and maxillofacial area. The most advanced methods are MRI, PET, tumor marker, immunohistopathological diagnostics. The results of the review can help improve the efficiency of cancer diagnosis and preventive complications in cancer patients. The relevance of this problem indicates the need to improve diagnostic and prevention methods, increase the level of “oncological alertness” of both doctors and patients themselves. The clinical and economic significance of early diagnosis and selection of the optimal treatment method for cancer patients determines the need to introduce the latest methods of cancer diagnosis, including analysis of the results of diagnostics.