The cultural spectra of homosexuality are briefly traced in Western and Eastern cultures. Special emphasis is placed on homosexuality in the male, which was a capital offense in the British Navy from 1700 to the early part of the nineteenth century when psychological and medical factors came to be considered of importance. In the American colonies the attitude toward male homosexuality and lesbianism is stated in a clear record of the views of Thomas Jefferson, who proposed in 1779 that "whoever shall be guilty of rape, polygamy or sodomy shall be punished if a man by castration, if a women by cutting through the cartilage of her nose a hole one-half inch in diameter at the least." The growing importance of Freudian theory led to research into child development and the stresses of entering the Oedipal period. Thanks to the insight of female psychoanalysts, Freud's original views were modified to patterns of boys and girls, and the relationship of these differences to the complex systems which may have produced homosexuality in may instances in both sexes. A thesis by Diane M. Greene entitled "Women Loving Women" is reviewed with special reference to the way women adapt to being in the world as lesbians. Prompted by what Bieber and Bieber wrote concerning the use of homosexual themes in males in solving problems related to achievement, e.g., creative success, salary increases, parenting, and drawing on psychoanalytic data, it is considered likely that women exercise similar mechanisms in solving analogous problems. It follows then that a few days delivery, a women could begin to doubt that she could handle this success-the need to mother. This could lead her to doubt her femininity, utilizing the same (hidden) homosexual mechanisms of problem solving in the male. An awareness of this process may assist the physician in management and therapy. Woods' paradigm for the male: I am a failure leads to I am castrated leads to I am not a man leads to I am like a women leads to I am homosexual. For the female, Mayberger and Abramson propose: I am a mother leads to I am successful leads to I cannot handle success because I lack the need to mother my infant lead to I am not a real women, I am like a man leads to I am homosexual.

Serotonin, when injected intracranially and intraabdominally into goldfish produces the surfacing reaction typical of hallucinogenic compounds active in man. It is suggested that serotonin disorders in the brain in man might be connected with the schizophrenias.

A simplified method of studying the surfacing reaction of goldfish to hallucinogens is described. Goldfish weighing up to three grams are injected intracranially. Employing this method, d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butano-lamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were found to be as pharmacologically active as previously noted in fish and in man. The relationship of these drugs to their anti-serotonin activity is of particular interest to the allergist because of the way in which the congeners and derivatives of LSD block the action of serotonin on smooth muscle.

"Will Intractable Epilepsy Respond to the Method Used in the Treatment of Intractable Asthma?." Journal of Asthma Research, 15(3), pp. VI–V

This second paper on the reassociation of dreams confirms 1. the value of reassociating a key dream (The Beetle Bug Dream) and 2. the use of lysergic acid diethyl amide (LSD) as an adjunct to psychoanalytic therapy. The patient (Joyce) was a young mother whose very severe eczema and asthma were accompanied by an incapacitating depression. The following summary of the three interviews indicate briefly the psychodynamic materials developed which helped Joyce uncover her confused sexual identifications and fear of lesbianism. In Interview 96 the initial Beetle Bug Dream was studied cautiously. On analysis the tentacles of the Beetle Bugs symbolically represented the hands of a man mauling a girl's skin. A sexual approach by a man is considered an attack. "Bugs get under the skin. If Jack (my husband) touches my skin, that spot itches." A second Beetle Bug is described. The special aspect of this unique Bug is that it was not threatening. This Bug is discussed in terms of the transference: the silent analyst and a father who responded to her childhood travail by silence are compared. Reassociation of the Beetle Bug Dream without LSD took place one year later. The session (Interview 235) lasted about 45 minutes and the verbatim recording occupied 12 typewritten pages. Free association led to the realization that the patient was programmed in part to identify with her father--a silent, passive individual. It was apparent that a psychological struggle for femininity, induced by the confused identification led to a threat of penetration by the sting of the Beetle Bug and, where a man was involved, penetration by the penis. Interview 236 (three days later) was conducted under LSD 25. The Beetle Bug Dream again formed the basis of this interview, which lasted four hours and occupied 46 pages of typewritten, verbatim material. A new feeling of independence from maternal influence is felt. "It used to be if I just thought of her, I could start scratching." The relationship with her husband is complicated by "deep, dark secrets." She is afraid of her husband. Her mother emphasized she was "one" with her father. Contact with aggressive males during adolescence, as well as seductive episodes were disturbing. In camp she feared that she might be a lesbian. This fear persisted into adult life. The threat of the Beetle Bug sting is developed further. Hostile feelings toward the penis are revealed in detail, The part of the penis in the vagina could be chopped off--the penis was what the sting of the Beetle Bug would be if it penetrated the skin. The bridegroom attacks the bride. An unwanted pregnancy is equivalent to the broken sting remaining in the skin. These revelations led to insight regarding unusual violent anger toward her child during toilet training. The data support the view that publication of verbatim recordings are a necessary condition for establishing psychoanalytic procedures as a basic science of medicine and of the validity of psychodynamic theory...

Happiness: “A state of well-being characterized by relative permanence, by dominant agreeable emotion ranging in value from mere contentment to deep and intense joy in living, and by a natural desire for its continuation.” (Webster)Happiness in Marriage: Husband and wife give each other sexual pleasure. Each endeavors to reduce old anxieties in the other. Each tries to avoid developing new anxieties in the other (H.A.A.)

Summary The effect of pH on the transport of lysergic acid diethylamide (LSD 25) and of methysergide has been studied in both Siamese fighting fish and goldfish. Two methods have been employed to study the transport of these drugs. In one method, the fish were immersed in a solution of the drug, thus providing an essentially unlimited supply of the drug in the outside liquid during the course of the experiment. In the second method, the fish were dipped for a much shorter period and then observed after the excess drug had been washed off. If has been found that the pH of the outside liquid, in both methods, is a major factor controlling the transport of LSD 25 and methysergide across the gills. Between pH 5.0 and pH 5.7, the surfacing reaction of the fish is diminished, with maximum blocking occurring at pH 5.0, the blocking effect diminishing to zero at pH 5.8. The data are discussed in connection with the permeability of the blood brain barrier of the nervous system to psychotomimetic drugs.