In the realm of precision psychiatry of mood disorders, the evolution of interpersonal psychotherapy (IPT) is gaining momentum, necessitating a personalized approach that also takes into account cultural aspects. This study underscores the importance of incorporating cultural factors into the dissemination and application of IPT in Asia. Through a comprehensive analysis of a case illuminating how cultural influences impact the onset and treatment outcomes of depression, we emphasize the critical need for culturally informed IPT practices in China. This personalized approach not only enhances treatment outcomes but also paves the way for further research on adapting IPT to diverse cultural contexts in Asia.

The separation of acetylene (C2H2) from carbon dioxide (CO2) is of great importance in industrial chemical processes but remains challenging due to their similar physical properties. Hydrogen-bonded organic frameworks (HOFs) have emerged as promising adsorbents, yet balancing their structural stability with separation performance requires further optimization. Herein, we report two ionic metal-hybrid HOFs (ZNU-29 and ZNU-30) constructed via ligand modulation and metallization strategies. ZNU-30 features one-dimensional ultramicroporous channels (2.66 × 3.66 Å2) lined with H2PO4- groups and electron-rich pyridine rings, creating a confined pore environment that combines molecular sieving and electrostatic interactions. At 298 K, ZNU-30 exhibits high C2H2 uptake (63.7 cm3/g) and significantly suppressed CO2 adsorption (5.6 cm3/g), leading to an exceptional ideal adsorbed solution theory (IAST) selectivity of 121 for an equimolar C2H2/CO2 mixture. Dynamic breakthrough experiments confirm its excellent practical separation capability. Density functional theory calculations reveal that the superior performance originates from stronger binding affinity and lower diffusion barriers for C2H2 compared to CO2, enabled by the precisely tailored pore geometry and electronegative pore environment. This work offers an effective strategy for designing stable and highly selective metal-hybrid HOFs for challenging gas separations.

Abstract The separation of mono‐ and di‐branched alkane isomers is an industrially important yet highly challenging process requiring precise pore structures. Here, we report a scalable metal–organic framework, Ni 3 (H 1.5 BTC) 2 (BTC)(DABCO) 3 (denoted as Ni‐HDB), featuring an anisotropic, “bat‐shaped” pore window that enables precise discrimination of the sterically similar 3‐methylpentane (3MP) and 2,3‐dimethylbutane (23DMB) pair (~0.3 Å difference in kinetic diameter), thereby enabling efficient separation of mono‐ and di‐branched isomers. Multicomponent vapor‐ and liquid‐phase experiments, supported by molecular simulations, reveal that separation arises from shape‐governed molecular accommodation rather than simple size exclusion. Notably, under industrially relevant liquid‐phase conditions, a packed column of pelleted Ni‐HDB directly produces a high‐octane gasoline fraction (RON > 91.5) from a five‐component alkane mixture, substantially exceeding the industrial benchmark of 83 for refined hexane mixtures. Combined with scalable synthesis, high stability, and low cost, this work establishes a practical, energy‐efficient route for liquid‐phase adsorptive upgrading of branched alkanes.

Thermally activated delayed fluorescence (TADF) emitters show great potential in photodynamic therapy (PDT) and bioimaging, leveraging their structural adaptability, efficient reverse intersystem crossing (RISC), robust photosensitizing capability, and high photoluminescence quantum yields (PLQYs). Herein, we developed a new class of donor-acceptor-donor (D-A-D)-type TADF materials by connecting the highly twisted indolizine-benzophenone electron acceptors with a series of electron donors including phenoxazine, phenothiazine and 9,9-dimethyl-9,10-dihydroacridine. These materials exhibit enhanced TADF properties, aggregation-induced emission (AIE), alongside high reactive oxygen species (ROS) generation efficiency, effectively mitigating aggregation-caused quenching observed in traditional fluorophores. Among them, IDP-p-PXZ, incorporating the phenoxazine donor, stands out with the smallest singlet-triplet splitting energy ( REST ) and the highest spin-orbit coupling matrix elements (SOCMEs). Upon encapsulation into 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-20 0 0] (DSPE-PEG2000) nanoparticles (NPs), IDP-p-PXZ demonstrates extended delayed fluorescence lifetimes in air, an exceptionally fast intersystem crossing (ISC) rate constant (kISC) of 3.4 x 107s-1, and a radiative rate constant (kr) of 5.05 x 106 s-1 . These NPs exhibit superior biocompatibility, efficient cellular internalization, and potent ROS production, enabling effective simultaneous PDT and confocal fluorescence imaging in HeLa cells. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Treatment‑resistant depression (TRD) is one of the toughest clinical challenges in psychiatry, characterized by high recurrence, heavy disease burden, and elevated suicide risk. Neuroimaging studies have mainly focused on single‑modality data, overlooking interactions between brain structure and function. This cross‑sectional study integrated multimodal MRI to examine alterations of structure-function coupling (SFC) and their associations with symptoms and diagnostic potential in TRD and non‑treatment‑resistant depression (nTRD). A total of 72 TRD patients, 152 nTRD patients, and 84 healthy controls were recruited. SFC was computed for each brain region from whole‑brain structural and functional data, and group differences, symptom correlations, and diagnostic classification were analyzed. TRD patients showed marked SFC decoupling in the right middle frontal gyrus, left inferior parietal lobule, left precentral gyrus, and right superior temporal gyrus. In nTRD, higher hippocampal SFC correlated with suicidal ideation and despair. Machine‑learning models based on SFC achieved high accuracy in distinguishing TRD from nTRD, outperforming previous unimodal approaches. These findings indicate that altered structure-function coordination represents a specific neural phenotype of TRD, linking network‑level decoupling with clinical symptoms and supporting its potential as an imaging‑based biomarker for individualized treatment. Trial Registration: ChiCTR2200055320, https://www.chictr.org.cn/showproj.aspx?proj=132558 . Registration date: January 1, 2022.

BACKGROUND:Visual motion perception (VMP) deficit in depression is mediated by the human middle temporal complex (hMT+). However, the reorganization of neuroactivity-perception in treatment-resistant depression (TRD) and the underlying molecular basis remain unclear. Therefore, this study aimed to investigate VMP-related pathophysiological mechanism in TRD. METHOD:Cohort 1 consisted of 72 TRD, 157 non-treatment-resistant depression (nTRD) and 85 healthy controls (HCs), while the cohort 2 was involved in 30 TRD, 30 nTRD and 30 HCs. Amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) with left hMT+ as seed was calculated for all participants. Using psychophysical task to test VMP in the cohort 2 and comparing the differences among groups in the fMRI measures. Their associations with genetic and neurotransmitter profiles were analysed by receptor/transporter density map and Allen Human Brain Atlas (AHBA). RESULTS:In the cohort 1, the left hMT+ of TRD exhibited decreased ALFF and its FC between the left inferior parietal lobule, right inferior temporal gyrus and middle frontal gyrus, but increased FC in the right fusiform gyrus. The ALFF of the left hMT+ were negatively correlated with cognitive impairment. Cohort 2 replicated and extended partial results from the cohort 1, underscoring the VMP-related ALFF abnormality of the left hMT+ in the TRD group. Moreover, the alterations of ALFF in left hMT+ was correlated with 10 neurotransmitters and expression map of specific genes which were enriched in synaptic structure and function. CONCLUSION:Deficits in VMP and cognitive processing of TRD are associated with hypoactivity in hMT+, accompanied by altered inter-regional connectivity. These alterations are linked to molecular and genetic factors, including the 5-HT1b receptor and PDCL3, implicating synaptic dysfunction as a potential pathophysiological basis. HMT+ is a promising neuroimaging biomarker for TRD and a novel therapeutic target for ameliorating the sensory and cognitive impairments.

The methanol-to-olefins process produces mixtures of ethylene and propylene, driving demand for high-performance separation materials. We present HOF-ZJNU-3, a hydrogen-bonded organic framework built from an expanded BTB (4,4′,4″-benzene-1,3,5-triyl-tribenzoate) linker, featuring the highest catenation degree observed in BTB-based HOFs. This unique architecture confers good stability under solvent, pH, and thermal conditions. With optimally sized pores and aromatic-rich surfaces, HOF-ZJNU-3 demonstrates excellent propylene/ethylene separation potential, outperforming its parent frameworks (HOF-BTB and HOF-BTB-NH 2 ) under ambient conditions. Notably, the material accomplishes single-cycle purification of high-purity ethylene (99.95%) and propylene (99.5%) from equimolar binary mixtures, achieving a record ethylene productivity of 3.22 mol kg −1 among HOF adsorbents. This study not only establishes HOF-ZJNU-3 as a benchmark HOF material for MTO product separation but also advances the structural design of HOFs for industrial olefin purification.

Due to the similar physicochemical properties of acetylene(C2H2)and carbon dioxide(CO2),separating C2H2 from a CO2/C2H2 mixture poses a significant challenge in the petrochemical industry.Herein,we successfully synthesized a novel SiF62-anion pillared cage metal-organic framework ZNU-15 possessing a new crs topological structure for the selective capture of C2H2.As a linear bidentate linker,the fluorinated SiF62-anion partitions the pores into various sized cages.ZNU-15 displays moderate adsorption for C2H2 with a capacity of 36.0 cm3 g-1 at 298 K and 1 bar,which is 2.7 times higher than the CO2 uptake.The IAST selectivity of C2H2/CO2 for ZNU-15 at 298 K and 100 kPa is 10.5,surpassing that of most reported materials.The Qst values for C2H2 and CO2 at zero coverage are 54.0 and 42.8 kJ mol-1,respectively.Moreover,breakthrough experimental tests show that ZNU-15 is capable of effectively separating C2H2 from a C2H2/CO2 mixture.Theoretical calculations further indicate that C2H2 is preferentially trapped by the small cage with four cooperative hydrogen bonds.

The separation of propylene (C3H6) from ethylene (C2H4) is one of the most vital processes to obtain high-purity C2H4 in the petrochemical industry, which is commonly limited by the insufficient C3H6 uptake or poor C3H6/ C2H4 selectivity due to the weak C3H6 binding affinity. Herein, a low-cost cobalt formate framework (termed as CoFA) was synthesized up to 40 g for efficient C3H6/C2H4 separation. CoFA with multiple accessible O delta- sites and contracted zigzag pore channels provides a unique single-molecule C3H6 nanotrap with benchmark high C3H6 adsorption affinity. The C3H6 uptake at 0.01 bar reaches as high as 59.4 cm3 cm-3, ranking second among the materials in the context of C3H6/C2H4 separation. Breakthrough experiments confirm its excellent separation capacity for equimolar C3H6/C2H4 mixtures. The separation performance is retained under 5 cycles and under humid conditions. Theoretical calculations reveal that the perfectly size-matched pore cavities combined with multiple hydrogen bonding sites enable this single-molecule C3H6 nanotrap to maximize the C3H6 binding affinity. The shaping properties of CoFA were investigated by using four different binders with PES as the best one to shape CoFA with retained capacity and selectivity.

The separation of acetylene (C2H2) from carbon dioxide (CO2) is important in industry but challenging due to their similar physical properties. Herein, a boron-rich 2D metal-organic framework ZNU-14 based on the carborane backbone was readily prepared by the supramolecular assembly of Zn2+, p-C2B10H10-(COOH)2, and di(pyridin-4-yl) amine under mild conditions for C2H2/CO2 separation. ZNU-14 displays a straight 1D channel (7.6 × 12.5 Å2) with an electronegative pore surface. Gas adsorption isotherms show that ZNU-14 has a good C2H2 adsorption capacity of 43.6 cm3 g-1, 181% of the CO2 uptake capacity. The calculated ideal adsorbed solution theory (IAST) selectivity is as high as 6.3-9.7, outperforming many popular materials. The moderate C2H2 adsorption heat of 34.3 kJ mol-1 facilitates the straightforward desorption and regeneration of ZNU-14. Furthermore, the theoretical study confirmed the stronger binding of C2H2 compared to that of CO2. The practical C2H2/CO2 separation performance was fully demonstrated by breakthrough experiments with excellent dynamic selectivity and recyclability under various conditions.

AbstractThe development of membranes with rapid and selective ionic transport is imperative for diverse electrochemical energy conversion and storage systems, including fuel cells and flow batteries. However, the practical application of membranes is significantly hindered by their limited conductivity and stability under strong alkaline conditions. Herein, a unique composite membrane decorated with functional Cu2+ cross‐linked chitosan (Cts‐Cu‐M) is reported and their high hydroxide ion conductivity and stability in alkaline flow batteries are demonstrated. The underlying hydroxide ions transport of the membrane through Cu2+ coordinated nano‐confined channels with abundant hydrogen bonding network via Grotthuss (proton hopping) mechanism is proposed. Consequently, the Cts‐Cu‐M membrane achieves high hydroxide ion conductivity with an area resistance of 0.17 Ω cm2 and enables an alkaline zinc‐based flow battery to operate at 320 mA cm−2, along with an energy efficiency of ≈80%. Furthermore, the membrane enables the battery for 200 cycles of long‐cycle stability at a current density of 200 mA cm−2. This study offers an in‐depth understanding of ion transport for the design and preparation of high‐performance membranes for energy storage devices and beyond.

The design of porous materials for CO2 capture from flue gas and natural gas is highly demanded. However, it is challenging to target materials that combine high CO2 capacity and CO2 selectivity. In this work, we report a robust metal-organic framework (MOF) Zn-ox-mtz with one dimensional channels and narrow windows for excellent CO2 capture from CO2/N-2 (simulated flue gas) and CO2/CH4 (simulated natural gas) with high selectivity. Zn-ox-mtz exhibits a high CO2 capacity (58.0 STP cm(3) g(-1) at 15 kPa), excellent CO2/N-2 (15/85, S > 10(6)) and CO2/CH4 (50/50, S > 10(5)) selectivity and good chemical stability. In addition, the practical separation performance is demonstrated by breakthrough experiments under various process conditions. A efficient separation is achieved with the impressive CO2 capacity of 2.60 +/- 0.12 mmol g(-1) at 298 K. Importantly, the outstanding performance is sustained under high humidity. The molecular sieving mechanism investigated by theoretical calculations indicated that CO2 with small molecular size is tightly trapped by multiple C = OH-C hydrogen bonding and O = CO forces in the cavity while CH4 and N-2 with larger molecular size display overlarge energy barrier to cross the contract pore windows. Moreover, the granulation of Zn-ox-mtz by hydroxypropyl cellulose is realized with high MOF loading (93.8 %) and the granulated Zn-ox-mtz beads retained the excellent CO2/N-2 and CO2/CH4 separation performance.

Separating acetylene (C2H2) from carbon dioxide (CO2) and ethylene (C2H4) presents a significant challenge in the industry due to their closely similar physical properties. Herein, we synthesized a novel [NbOF5]2- pillared microporous metal-organic framework ZNU-11 with abundant electronegative sites for efficient C2H2/CO2 and C2H2/C2H4 adsorption separation. The uncoordinating fluorine atoms in the confined pores selectively capture C2H2 from CO2 and C2H4 by hydrogen bonding interactions. The C2H2 capacity of ZNU-11 is 45.5 cm3/g at 298 K and 100 kPa, over three folds of the C2H4 uptake and two folds of the CO2 uptake. The relatively modest C2H2 adsorption heat of 36.1 kJ/mol facilitates the straightforward desorption and regeneration of ZNU-11. Furthermore, density functional theory (DFT) calculations confirmed the stronger binding of C2H2 compared to CO2 and C2H4. Experimental breakthroughs with C2H2/CO2 and C2H2/C2H4 gas mixtures, coupled with excellent recyclability, validated the practical separation performance of ZNU-11. Notably, the dynamic separation factor of 4.2 for equimolar C2H2/CO2 mixture rivals those of many benchmark materials.

Objective: To assess the efficacy and safety of Vortioxetine and Escitalopram in improving cognition in patients with major depressive disorder (MDD). Methods: At baseline, 131 MDD patients and 70 healthy controls completed the Hamilton Depression Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), Snaith-Hamilton Pleasure Scale (SHAPS) and MATRICS Consensus Cognitive Battery (MCCB). Patients with MDD were randomly divided into Vortioxetine (n = 62) and Escitalopram (n = 69) groups with an 8-week follow-up research. ANOVA for repeated measurement was utilized to compare the efficacy of Vortioxetine and Escitalopram. Results: The total scores of HAMD-17, HAMA and SHAPS scales had statistical difference between MDD cases and healthy controls (P < 0.001) at baseline. After 8 weeks of treatment, the scale scores of the HAMD-17, HAMA and SHAPS had lowered in both groups, with no statistical difference between two groups (P > 0.05). At baseline, MDD patients had defects in Speed of Processing, Attention Vigilance, Verbal Learning, Visual Learning, Reasoning and Problem Solving, and Social Cognition, compared with healthy controls. After 8 weeks of treatment with Vortioxetine or Escitalopram, the patients had improved in the aspects of cognitive functions above except Social Cognition. Numerical improvements of MCCB scale were found in the two groups, P > 0.05. Most adverse events were mild or moderate, with nausea being the most common adverse event. Conclusion: Both Vortioxetine and Escitalopram can improve the mental status and cognitive functions in MDD patients, with mild or moderate adverse events.

Extensive efforts have been made to improve the separation selectivity of hydrocarbon isomers with nearly distinguishable boiling points; however, how to balance the high regeneration energy consumption remains a daunting challenge. Here we describe the efficient separation of hexane isomers by constructing and exploiting the rotational freedom of organic linkers and inorganic SnF 6 2− anions within adaptive frameworks, and reveal the nature of flexible host-guest interactions to maximize the gas-framework interactions while achieving potential energy storage. This approach enables the discrimination of hexane isomers according to the degree of branching along with high capacity and record mono-/di-branched selectivity (6.97), di-branched isomers selectivity (22.16), and upgrades the gasoline to a maximum RON (Research Octane Number) of 105. Benefitting from the energy regulation of the flexible pore space, the material can be easily regenerated only through a simple vacuum treatment for 15 minutes at 25 °C with no temperature fluctuation, saving almost 45% energy compared to the commercialized zeolite 5 A. This approach could potentially revolutionize the whole scenario of alkane isomer separation processes.

Since ethylene (C2H4) is important feedstock in the chemical industry, developing economical and energy-efficient adsorption separation techniques based on ethane (C2H6)-selective adsorbents to replace the energy-intensive cryogenic distillation is highly demanded, which however remains a daunting challenge. While previous anionic boron cluster hybrid microporous materials display C2H4-selective features, we herein reported that the incorporation of a neutral para-carborane backbone and aliphatic 1,4-diazabicyclo[2.2.2]octane (DABCO) enables the reversed adsorption of C2H6 over C2H4. The generated carborane-hybrid microporous material ZNU-10 (ZNU = Zhejiang Normal University) is highly stable in humid air and maintains good C2H6/C2H4 separation performance under high humidity. Gas loaded single crystal structure and density-functional theory (DFT) calculations revealed that the weakly polarized carborane and DABCO within ZNU-10 induce more specific C-Hδ+⋯Hδ--B dihydrogen bonds and other van der Waals interactions with C2H6, while the suitable pore space allows the high C2H6 uptake. Approximately 14.5 L kg-1 of polymer grade C2H4 can be produced from simulated C2H6/C2H4 (v/v 10/90) mixtures under ambient conditions in a single step, comparable to those of many popular materials.

The recovery of perfluorocarbons (PFCs), such as CF4 and C2F6, from exhaust gas can not only reduce the emissions of greenhouse gas but also improve the utilization of PFCs in the semiconductor industry. In this work, a high-throughput computational evaluation for nearly 10 000 MOFs in the CoRE MOF database was performed to evaluate the potential of metal-organic frameworks (MOFs) for the recovery of trace CF4 and C2F6 from N-2-containing gas. Various adsorbent performance metrics, including adsorption selectivity, working capacity, recovery rate, and adsorbent performance score, were calculated to evaluate the top-performing MOFs, and 10 top-performing MOFs for efficient capture of CF4 and C2F6 over N-2 were identified from a computation-ready experimental (CoRE) MOF database. The machine learning model analysis reveals that the LCD as well as the adsorption heat difference between PFCs with N-2 play dominant roles in PFCs recovery. Furthermore, five design and optimization strategies, including adjustment or functionalization of the organic linker, substitution of metal node, regulation of topology net, and optimization of synthesis condition, were provided to guide the development of high-performing MOFs for PFCs recovery.

The design of molecular sieves is vital for gas separation, but it suffers from a long-standing issue of slow adsorption kinetics due to the intrinsic contradiction between molecular sieving and diffusion within restricted nanopores. We report a molecular sieve ZU-609 with local sieving channels that feature molecular sieving gates and rapid diffusion channels. The precise cross-sectional cutoff of molecular sieving gates enables the exclusion of propane from propylene. The coexisting large channels constituted by sulfonic anions and helically arranged metal-organic architectures allow the fast adsorption kinetics of propylene, and the measured propylene diffusion coefficient in ZU-609 is one to two orders of magnitude higher than previous molecular sieves. Propylene with 99.9% purity is obtained through breakthrough experiments with a productivity of 32.2 L kg-1.