Methods: This prospective cohort study was conducted in Yinzhou, China, comprising 27,882, participants aged over 18 years. Normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) were used to characterize greenspace around each participant's residence. A land use regression (LUR) model was developed to estimate NO2 concentrations, and outdoor LAN was assessed using satellite-derived images. Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs), and restricted cubic splines (RCS) were utilized to depict exposure-response curves. Additionally, we applied a cumulative risk index (CRI) to quantify joint effects of co-existing exposures and explored both additive and multiplicative interactions as well as mediating effects. Results: Over a median follow-up of 5.10 years, a total of 3,272 incident anxiety cases were identified. In singleexposure models, HRs (95 % CIs) per interquartile range (IQR) increment were 0.73 (0.70, 0.77) for NDVI 250 m, 1.20 (1.10, 1.30) for NO2, and 1.21 (1.17, 1.24) for LAN, respectively. Both greenness and LAN exhibited notable deviations from linearity. Furthermore, the highest joint hazard ratio (JHR) of 1.42 (95 % CI: 1.30, 1.55) was observed when participants were simultaneously exposed to reduced greenness and elevated NO2. Additive and multiplicative interactions were observed between greenness and NO2, as well as between NO2 and LAN. Mediation analyses revealed that 28 % (95 % CI: 14 %, 45 %) of the relationship between NDVI 250 m and anxiety was mediated by reduced LAN. Conclusions: Residential greenness was inversely associated with anxiety incidence, whereas exposure to NO2 and exacerbated by greater exposure to nighttime illumination. Our findings underscore the urgency of integrating

RNase5 suppresses intestinal tumorigenesis

Characterization of RNase5 and its mutants

Cellular distribution change of RNase5 during normal crypt-adenoma-carcinoma transition

AIMS:To compare cardiovascular and microvascular outcomes associated with metformin versus sulfonylurea therapy among patients with early-onset (<40 years) and late-onset (≥40 years) type 2 diabetes. MATERIALS AND METHODS:We conducted a population-based cohort study of adults with newly diagnosed type 2 diabetes who initiated metformin or sulfonylurea between 2010 and 2021 in Yinzhou Health Information System (YHIS). Participants were stratified by age at diagnosis and matched 1:1 using propensity scores. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for cardiovascular disease (CVD) and microvascular disease (MVD). Sensitivity analyses included extended landmarks, inverse probability weighting, and negative control outcomes. RESULTS:After matching, 1267 early-onset and 18 409 late-onset pairs were included. Sulfonylurea use was associated with higher CVD risk than metformin, especially in early-onset type 2 diabetes (HR = 1.69, 95% CI 1.10-2.60), with a smaller increase in late-onset disease (HR = 1.07, 95% CI 1.02-1.13; p interaction = 0.037). MVD risks were similar between treatments across age groups. Sensitivity analyses showed consistent results. CONCLUSIONS:Sulfonylurea therapy was linked to increased cardiovascular risk, particularly in younger patients, while microvascular outcomes were comparable. These findings support metformin as the preferred first-line therapy for early-onset type 2 diabetes.

Clinical Characteristics of 39 Incident CRC Patients

Associations Between Baseline RNase5 Level (Per 10 ng/mL Increase) and Risk of Incident CRC

Serum RNase5 levels progressively increase during colorectal tumorigenesis in mouse models

Clinical Characteristics of 487 Incident CRC Patients

RNase5 deficiency results in elevated β-catenin protein synthesis and downstream signaling activation

RNase5 expression in serum and intestinal tissue

tiRNA prevents intestinal tumor initiation

RNase5 deficiency increases proliferative capacity and number of crypt cells

RNase5 deficiency results in a more undifferentiated and proliferative state of stem cells in aged mice, and increases stem cell activity

The joint effects of complex built environment exposures on sleep duration and their underlying mechanisms remain unclear. This study aimed to evaluate the overall effects of residential built environment mixtures on longitudinal changes in sleep duration, and to explore potential mediation through air pollution. We analyzed data from 18,891 adults in Yinzhou cohort in China, with baseline (2015–2017) and follow-up (2021–2023) assessments. Sleep duration was self-reported via questionnaires. Linear mixed models and quantile g-computation were employed to evaluate the associations between built environment mixture (green and blue space, light at night [LAN], walkability, road proximity, and population density) and longitudinal change of sleep duration. Structural equation modeling was utilized to assess mediation by air pollutants (PM10, PM2.5, and NO2). Each quartile increase in the built environment mixture index was associated with a 0.057 h/year (95

RNase5 deficiency maintains elevated protein synthesis in intestinal tumors

RNase5-produced tiRNAs repress protein synthesis and cell proliferation in cultured organoids

RNase5 deficiency downregulates tiRNA level in crypts

Ribonuclease activity and cellular internalization, but not nuclear localization, are required for RNase5-mediated suppression of intestinal organoid hyperproliferation