The direct anterior approach (DAA) and the posterolateral approach (PLA) are commonly used surgical techniques in total hip arthroplasty (THA). However, whether DAA is associated with different wound complication rates compared with PLA remains controversial. This meta-analysis aimed to compare wound complications and clinical outcomes between DAA and PLA in THA based on randomized controlled trials. A comprehensive search was conducted across six major electronic databases: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Chongqing VIP Information (CQVIP). The search strategy encompassed studies indexed from database inception to 31 December 2025. The primary outcomes were wound complications, including incisional infection, hematoma, and delayed wound healing. Predefined eligibility criteria were applied during study screening. The risk of bias of the included studies was assessed using the revised Cochrane Risk of Bias tool for randomized trials (RoB 2). The PLA group was used as the control group. Data were extracted from the included randomized controlled trials (RCTs). A pooled statistical analysis was performed to estimate the rate of wound complications and to compare the clinical effects of DAA and PLA. The meta-analysis was conducted with Review Manager 5.3 and Stata 15. A total of 18 eligible RCTs, comprising 1,485 patients, were included. Compared with PLA, DAA was associated with decreased rates of incisional infection (RR = 0.48, P = 0.03, I2 = 0

Abstract Objective To systematically assess the efficacy and safety of the proximal femoral bionic nail (PFBN) compared with the InterTAN nail in the management of intertrochanteric femoral fractures (IFFs) among elderly individuals. Methods Eligibility criteria (inclusion and exclusion) were established in accordance with the PICOS framework. Relevant clinical studies were systematically retrieved from both Chinese (CNKI, VIP, and Wanfang Data) and English databases (PubMed, Embase, Web of Science, the Cochrane Library) with a search cutoff date of October 31, 2025. The Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool was employed to appraise methodological quality of the included literature. Meta-analyses of outcome measures, including intraoperative duration, intraoperative haemorrhage, length of hospital stay, postoperative weight-bearing duration, Harris Hip Score (HHS), and internal fixation-related complications, were conducted using RevMan 5.3 and Stata 15 software. Results Six relevant studies were finally enrolled in the present analysis, consisting of 2 prospective cohort studies and 4 retrospective cohort studies, with a total of 683 participants. Among all cases, 334 patients were allocated to the PFBN group and the remaining 349 cases received InterTAN nail fixation. Meta-analysis outcomes demonstrated no significant inter-group differences in intraoperative blood loss ( P = 0.17), postoperative weight-bearing time ( P = 0.47) and Harris Hip Score (HHS) ( P = 0.11). When compared with the InterTAN nail system, the PFBN group presented a shorter hospital stay ( P = 0.04) and a decreased rate of internal fixation-related complications ( P = 0.01), whereas the PFBN group had a longer operative time ( P = 0.03). Sensitivity analysis further confirmed the good overall stability and reliability of the pooled outcomes in this meta-analysis. Conclusion Based on the limited evidence from current non-randomized studies, PFBN exhibits potential benefits in shortening hospital duration and reducing the risk of internal fixation-related complications among elderly patients with intertrochanteric femoral fractures. Meanwhile, this implant yields equivalent effects to the InterTAN nail with regard to functional recovery. Given the observational design of all included trials and substantial heterogeneity in several outcomes, these findings warrant cautious interpretation.

Low back pain (LBP) is a global health concern with varying incidence across regions. Recognizing these regional differences is essential for creating effective prevention and control strategies. This study examines the burden and trends of LBP globally using recent data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). We extracted GBD data on prevalence, incidence, and disability-adjusted life years (DALYs) for LBP from 1990 to 2021 via the Global Health Data Exchange (GHDx). Crude and age-standardized rates (ASRs) and estimated annual percentage changes (EAPCs) were calculated globally, and by region, country, age, and sex. Decomposition, frontier, and cluster analyses were applied to identify influencing factors and trends. In 2021, there were 629 million (95% UI: 552-701 million) prevalent cases, 267 million (95% UI: 235-299 million) incident cases, and 70.16 million (95% UI: 65.76 to 83.22 million) DALYs due to LBP globally. From 1990 to 2021, ASRs of prevalence (EAPC = -0.32), incidence (EAPC = -0.29), and DALYs (EAPC = -0.32) declined. Central Europe and Hungary showed the highest burden, while Asia and China had the largest number of affected individuals. High Socio-demographic Index (SDI) regions exhibited the highest ASRs, whereas middle SDI regions had the lowest. Population growth and aging contributed to increasing case numbers, with burden peaking at ages 80-84 and being higher among females. Despite a slight decline in age-standardized rates, the global burden of LBP remains high, with marked regional and demographic disparities. Targeted health policies, particularly for elderly women in high-SDI regions, are essential to effectively reduce the burden of LBP worldwide.

Background:Rosa roxburghii Tratt. (Cili), a medicinal-edible herb predominantly distributed in Guizhou Province, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, and cell proliferation-promoting effects. Despite its recognized pharmacological value, the therapeutic efficacy and underlying mechanisms in fracture healing remain unexplored. This study aims to systematically investigate its potential mechanisms by integrating network pharmacology and molecular docking.Methods:The components of R. roxburghii Tratt. were retrieved from the PubChem, CNKI, VIP, and WANFANG databases, and their corresponding targets were screened from public databases. The targets of fracture healing were obtained from the GeneCards and OMIM databases. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed the mechanisms of R. roxburghii Tratt. in fracture healing. The potential targets and core components were identified by constructing a protein-protein interaction network and a series of topological networks. Finally, molecular docking was performed to validate the binding of the core targets to the components.Results:Gene Ontology analysis highlighted its regulation of vascular endothelial growth factor signaling pathway, cell migration, epidermal growth factor receptor signaling pathways, and fibroblast growth factor receptor signaling pathways. Kyoto Encyclopedia of Genes and Genomes analysis suggested that R. roxburghii Tratt.'s mechanism may involve key pathways, such as hypoxia-inducible factor 1, phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase, tumor necrosis factor, and ras-associated protein-1 signaling pathway, while topological network analysis identified 4 core targets (tumor necrosis factor, prostaglandin G/H synthase 2, epidermal growth factor receptor, and proto-oncogene tyrosine-protein kinase Src) and 21 core components (naringenin, quercetin, kaempferol, isorhamnetin, luteolin, myricetin, etc), all critically associated with osteogenesis and angiogenesis. Molecular docking confirmed strong binding between these components and targets.Conclusion:These findings propose that R. roxburghii Tratt. may accelerate fracture healing by multitarget, components, and pathways regulating osteogenesis and angiogenesis, providing a scientific basis for its development and utilization.

Intervertebral disc degeneration is a multifactorial degenerative disease that poses a significant threat to the health of the elderly population. Current treatments primarily focus on physical therapy, medication, and surgery to alleviate symptoms associated with disc compression but do not address the progression of degeneration. Therefore, this review aimed to explore the potential of extracellular vesicle therapy as a novel preventive strategy to delay degeneration and enhance tissue repair in intervertebral discs. We cover the pathogenic mechanisms underlying intervertebral disc degeneration, including inflammation, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and the roles of non-coding RNAs. Subsequently, we discussed the therapeutic potential of extracellular vesicles and their molecular components, such as proteins, RNAs, and lipids, in modulating these pathways to counter intervertebral disc degeneration. We provides a comprehensive review of the significant role of extracellular vesicle cargo in mediating repair mechanisms. It discusses the functional enhancement advantages exhibited by extracellular vesicles under current bioengineering modifications and drug loading. The challenges and future prospects of utilizing extracellular vesicle therapy to treat this degenerative condition are also summarized.

To comprehensively analyze the prevention, diagnosis and management strategies of periprosthetic joint infections(PJIs), provide new ideas for overcoming PJI, and provide references for clinicians. By synthesizing the latest research results at home and abroad, this study deeply analyzed the multidimensional prevention strategies, diagnostic criteria and technological advances, and treatment management strategies for PJI. The management of PJI remains a significant challenge in orthopedic surgery, which warrants focused attention. The prevention of PJI holds paramount priority and should be integrated throughout the perioperative period. Although diagnostic criteria for PJI have undergone multiple updates, the 2011 MSIS criteria remain the most widely adopted, requiring comprehensive evaluation of laboratory, pathological, and imaging examinations for diagnosis. PJI treatment necessitates combined antibiotic and surgical interventions. Antibiotic therapy includes empirical treatment after diagnosis, targeted therapy following pathogen identification, and suppressive antibiotic therapy(SAT) for non-surgical candidates. Surgical options comprise debridement, antibiotics, and implant retention(DAIR), one-stage/two-stage revision, and salvage procedures. Implementation of standardized infection prevention protocols, rational antibiotic use, surgical technical innovations, and advancements in biomaterials have contributed to a reduction in PJI incidence. However, the spread of bacterial resistance and multidrug-resistant organisms in healthcare settings pose new challenges for PJI prevention and treatment. In the future, the research and development of new antimicrobial materials, the innovation of biofilm control technology and the application of precision medicine are expected to further reduce the incidence of PJI, improve the quality of life of patients, and promote a breakthrough in the field of arthroplasty regarding this issue.

BACKGROUND:In recent years, the number of studies on spondylolisthesis has been increasing, and there are many publications on this disorder. To our knowledge, there is no bibliometric analysis of spondylolisthesis to date. AIM:To investigate emerging directions in Spondylolisthesis research and systematically evaluate the academic literature with the highest citation impact within this field. METHODS:All data were collected from the Web of Science Core Collection database. Years of publications, countries, journals, institutions and total number of citations were extracted and analyzed by VOSviewer software. In addition, we analyzed the top 100 most-cited articles on spondylolisthesis. RESULTS:A total of 1831 articles related to spondylolisthesis were identified. The frequency of publications on spondylolisthesis has increased dramatically over time. Among all countries, United States has contributed the most publications on spondylolisthesis (n = 574). The institution with the most articles was the University of California, San Francisco (n = 52). Spine topped the list of journals and has published 291 spondylolisthesis-related reports. The hotspot of research changed from posterolateral fusion to interbody fusion. CONCLUSION:In recent years, academic investigations on spondylolisthesis have exhibited significant growth. As the inaugural bibliometric evaluation in this domain, our research establishes a methodological framework for synthesizing the historical progression and current advancements of spondylolisthesis studies.

Phase I study showed comparable pharmacodynamic, safety and pharmacokinetic profiles of denosumab biosimilar CMAB807 and reference product Prolia® in healthy males. However, the efficacy and safety of CMAB807 in postmenopausal women with osteoporosis were unknown. To compare the efficacy and safety of CMAB807 and Prolia® in Chinese postmenopausal women with osteoporosis. This randomized, double-blind, active-controlled study enrolled Chinese postmenopausal women with osteoporosis. Participants received either CMAB807 or Prolia® 60 mg every 6 months for 12 months. The primary endpoint was the percentage change in BMD at lumbar spine (LS) from baseline to month 12. Secondary endpoints included BMD changes at LS at month 6, total hip (TH) and femoral neck (FN) at month 6 and 12. Additionally, bone turnover markers (BTMs) and incidence of new fragility fractures were evaluated. Safety assessments were also included. A total of 284 women were enrolled, with 276 (97.2

Fracture surgeries are frequently accompanied by severe pain, necessitating efficacious pain management strategies to enhance postoperative recovery. Nerve block techniques, which are critical in mitigating pain, involve the targeted administration of local anesthetics to disrupt nerve signal transmission, thereby achieving significant analgesia. Traditionally, these techniques rely on anatomical landmarks and the clinician's expertise, which can introduce variability and potential risks. The adoption of ultrasound-guided nerve blocks has increased, facilitated by advancements in imaging technology. This approach enables precise placement of anesthetics through real-time visualization of neural structures and adjacent tissues, significantly improving the accuracy and safety of the procedure. This review summarizes recent advancements in the application of ultrasound-guided nerve block techniques in fracture surgeries, particularly for rib, upper limb, thoracic, lumbar, and hip fractures. By precisely placing local anesthetics, these techniques not only improve the safety and efficiency of surgeries but also significantly reduce postoperative pain and recovery time. The widespread application of ultrasound-guided nerve blocks offers an efficient and low-side-effect anesthesia management strategy, enhancing post-surgical patient experience and recovery quality.

To systematically evaluate the effectiveness of the Problem-based learning (PBL) combined with Case-based learning (CBL) teaching method compared with the Lecture-based learning (LBL) method in orthopedic education and provide evidence for optimizing orthopedic teaching methods. Literature was systematically searched in Chinese and English databases and screened using strict inclusion/exclusion criteria. The Cochrane Risk of Bias Tool was used to assess the methodological quality of the literature. Meta-analyses were performed with RevMan 5.3 and Stata 16 software. We compared the application effects of the PBL-CBL teaching method versus the LBL teaching method in orthopedic education across multiple dimensions: theoretical knowledge mastery, practical skill proficiency, comprehensive competency development, and satisfaction with teaching methods. (1) 15 studies involving 980 participants were included. (2) Meta-analysis showed significant superiority of PBL-CBL over LBL in: ①Objective outcomes: theoretical knowledge (SMD = 1.46, P < 0.0001), practical skills (SMD = 1.53, P < 0.0001), physical examination (SMD = 1.64, P < 0.0001), case analysis (SMD = 1.30, P < 0.0001), and plaster immobilization (SMD = 2.42, P < 0.0001); ② Subjective outcomes: debridement proficiency (RR = 1.44, P = 0.001), aseptic awareness (SMD = 1.58, P = 0.003), and other comprehensive competencies (self-learning, learning interest, learning efficiency, clinical thinking, team collaboration, etc., P < 0.001 for all). Satisfaction with the teaching method was also significantly higher (RR = 1.34, P < 0.0001). (3) Heterogeneity was observed in the study (I2 = 77–87

Background:The TBS is a new method for clinicians to assess bone quality. It is directly related to the mechanical strength of bone and helps predict fracture risk. The present analysis aimed to the associations between serum PTH level and TBS by analyzing data from the National Health and Nutrition Examination Survey (NHANES).Methods.A total of 3516 participants from the NHANES 2005–2006 were included in this cross-sectional analysis. Independent variables were serum PTH, which a key role in mineral homeostasis and bone metabolism. Outcome variable was TBS. The associations of serum PTH levels with TBS was examined using multivariable linear regression models.Results.After adjusting for covariates, there was a negative association between the serum PTH level and TBS (β= -0.0034; 95% confidence interval, -0.0050– -0.0017). However, in the subgroup analysis stratified by gender, race, and age, this association became negative only in Non-Hispanic White (β = − 0.0047, 95% CI: − 0.0071– − 0.0048) and young people (age＜60) (β = − 0.0036, 95% CI: -0.0057, -0.0016). In addition, the association of serum PTH with TBS was an inverted U-shaped curve, with a point of inflection a 6.71 pmol/L.Conclusion:This study showed that serum PTH levels were negative associated with TBS. This finding indicated that maintaining PTH at low levels may be beneficial to bone health, especially for young non-Hispanic white.

BackgroundThe causality of autoimmune diseases with frailty has not been firmly established. We conducted this Mendelian randomization (MR) study to unveil the causal associations between autoimmune diseases with frailty.MethodsA MR analyses were performed to explore the relationships between autoimmune disease and frailty, using summary genome-wide association statistics.ResultsThrough a comprehensive and meticulous screening process, we incorporated 46, 7, 12, 20, 5, and 53 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for hypothyroidism, hyperthyroidism, rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), and overall autoimmune disease, respectively. Our analysis revealed that hypothyroidism (OR = 1.023, 95% CI: 1.008–1.038, p = 0.0015), hyperthyroidism (OR = 1.024, 95% CI: 1.004–1.045, p = 0.0163), RA (OR = 1.031, 95% CI: 1.011–1.052, p = 0.0017), T1D (OR = 1.011, 95% CI: 1.004–1.017, p = 0.0012), and overall autoimmune disease (OR = 1.044, 95% CI: 1.028–1.061, p = 5.32*10^-8) exhibited a positive causal effect on frailty. Conversely, there may be a negative causal association between MS (OR = 0.984, 95% CI: 0.977–0.992, p = 4.87*10^-5) and frailty. Cochran’s Q test indicated heterogeneity among IVs derived from hypothyroidism, hyperthyroidism, T1D, and overall autoimmune diseases. The MR-Egger regression analyzes revealed an absence of horizontal pleiotropy in any of the conducted analyses.ConclusionThis study elucidates that hypothyroidism, hyperthyroidism, RA, T1D, and overall autoimmune disease were linked to an elevated risk of frailty. Conversely, MS appears to be associated with a potential decrease in the risk of frailty.

BACKGROUND The pedicle screw technique is widely employed for vertebral body fixation in the treatment of spinal disorders. However, traditional screw placement methods require the dissection of paraspinal muscles and the insertion of pedicle screws at specific transverse section angles (TSA). Larger TSA angles require more force to pull the muscle tissue, which can increase the risk of surgical trauma and ischemic injury to the lumbar muscles. AIM To study the feasibility of zero-degree TSA vertical pedicle screw technique in the lumbosacral segment. METHODS Finite element models of vertebral bodies and pedicle screw-rod systems were established for the L4-S1 spinal segments. A standard axial load of 500 N and a rotational torque of 10 N/m were applied. Simulated screw pull-out experiment was conducted to observe pedicle screw resistance to pull-out, maximum stress, load-displacement ratio, maximum stress in vertebral bodies, load-displacement ratio in vertebral bodies, and the stress distribution in pedicle screws and vertebral bodies. Differences between the 0-degree and 17-degree TSA were compared. RESULTS At 0-degree TSA, the screw pull-out force decreased by 11.35% compared to that at 17-degree TSA (P < 0.05). At 0-degree and 17-degree TSA, the stress range in the screw-rod system was 335.1-657.5 MPa and 242.8-648.5 MPa, separately, which were below the fracture threshold for the screw-rod system (924 MPa). At 0-degree and 17-degree TSA, the stress range in the vertebral bodies was 68.45-78.91 MPa and 39.08-72.73 MPa, separately, which were below the typical bone yield stress range for vertebral bodies (110-125 MPa). At 0-degree TSA, the load-displacement ratio for the vertebral bodies and pedicle screws was slightly lower compared to that at 17-degree TSA, indicating slightly lower stability (P < 0.05). CONCLUSION The safety and stability of 0-degree TSA are slightly lower, but the risks of screw-rod system fracture, vertebral body fracture, and rupture are within acceptable limits.

[This corrects the article DOI: 10.1016/j.mtbio.2022.100512.].

Background Subglottic Stenosis (SGS), with increasing numbers of studies, is the most specific and common clinical type of Laryngotracheal Stenosis (LTS). There is rapid publication turnover with newer management introduced and expanding research field. To our knowledge, there is no bibliometric analysis of SGS yet. Methods In August 2022, we performed a thorough search in the Web of Science Core Collection database using the word “subglottic stenosis,” and “SGS.” The 580 articles were arranged based on correlation. The collected articles were then analyzed with an assessment of relevant factors. Meanwhile, we analyzed the top 100 most-cited articles on SGS. Results The frequency of publication on SGS has increased substantially over time. The USA has contributed the most articles ( n = 301). Vanderbilt University published most of the articles among other institutions ( n = 18). Laryngoscope topped the list of journals and has published 89 SGS-related articles. Research hotspots shift from surgical treatment to conservative management. Conclusions The SGS-related literature has grown rapidly in recent years. This study represents the first bibliometric analysis of scientific articles on SGS. Areas to improve in SGS research can be identified after this analysis of the most impactful articles on this topic.

Objectives: This study aimed to investigate the correlations of spinopelvic parameters with the quality of life of patients with adult degenerative scoliosis (ADS) after posterior correction, and their relationships with efficacy. Patients and methods: Ninety patients (40 females, 50 males; mean age: 62.4 +/- 3.3 years; range, 47 to 73 years) with adult spinal deformity treated from March 2016 to May 2020 were retrospectively enrolled. The Scoliosis Research Society (SRS)-22 questionnaire was filled in by the patients, and the Oswestry disability index (ODI) and Visual Analog Scale (VAS) for back and lower limb pain were assessed. All the patients underwent posterior correction. Spearman's analysis was conducted for the correlations of the spinopelvic sagittal parameters with quality of life. The risk factors for efficacy were identified using the multivariate logistic regression model to construct a nomogram model for efficacy and risk prediction. Results: After the operation, significant reductions were detected in the sagittal vertical axis (SVA), pelvic tilt (PT), T1 pelvic angle (TPA), pelvic incidence minus lumbar lordosis (PI-LL), and the ODI score (p<0.05). The SVA and LL were significantly negatively correlated with all subitems on the SRS-22 questionnaire but positively correlated with VAS scores for back pain (p<0.05). Thoracic kyphosis was significantly positively correlated with self-image and mental status on the SRS-22 questionnaire (p<0.05), while TPA was negatively correlated with pain and self-image (p<0.05). The PI-LL was significantly negatively correlated with pain (p<0.05). Conclusion: The SVA, LL, PT, and PI-LL were independent predictors of improvement in ODI after operation for ADS. The postoperative changes in spinopelvic parameters affected the clinical outcomes in patients with ADS. Keywords: Degenerative scoliosis, posterior correction, quality of life, spinopelvic parameter, therapeutic effect.

Type I interferons (IFN-I) are pleiotropic factors endowed with multiple activities that play important roles in innate and adaptive immunity. Although many studies indicate that IFN-I inducers exert favorable effects on broad-spectrum antivirus, immunomodulation, and anti-tumor activities by inducing endogenous IFN-I and IFN-stimulated genes, their function in bone homeostasis still needs further exploration. Here, our study demonstrates 2 distinct IFN-I inducers, diABZI and poly(I:C), as potential therapeutics to alleviate osteolysis and osteoporosis. First, IFN-I inducers suppress the genes that control osteoclast (OC) differentiation and activity in vitro. Moreover, diABZI alleviates bone loss in Ti particle-induced osteolysis and ovariectomized -induced osteoporosis in vivo by inhibiting OC differentiation and function. In addition, the inhibitory effects of IFN-I inducers on OC differentiation are not observed in macrophages derived from Ifnar1-/-mice, which indicate that the suppressive effect of IFN-I inducers on OC is IFNAR-dependent. Mechanistically, RNAi-mediated silencing of IRF7 and IFIT3 in OC precursors impairs the suppressive effect of the IFN-I inducers on OC differentiation. Taken together, these results demonstrate that IFN-I inducers play a protective role in bone turnover by limiting osteoclastogenesis and bone resorption through the induction of OC-specific mediators via the IFN-I signaling pathway.

Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation-induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide, bonded on PG@Cu nanoparticles via a Schiff base bond, imparts multifunctionality to the metal polyphenol particles (PG@Cu-FP). PG@Cu-FP exhibits enhanced escape from lysosomal capture, enabling efficient targeting of mitochondria to scavenge excess reactive oxygen species. The scavenging activity against reactive oxygen species originates from the polyphenol-based structures within the nanoparticles. Furthermore, Pyroptosis is effectively blocked by inhibiting Gasdermin mediated pore formation and membrane rupture. PG@Cu-FP successfully reduces the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 inflammasome by inhibiting Gasdermin protein family (Gasdermin D, GSDMD) oligomerization, leading to reduced expression of Nod-like receptors. This multifaceted approach demonstrates higher efficiency in inhibiting Pyroptosis. Experimental results confirm that PG@Cu-FP preserves disc height, retains water content, and preserves tissue structure. These findings highlight the potential of PG@Cu-FP in improving IVDD and provide novel insights for future research in IVDD treatments.

Senescent cells accumulate in multiple tissues with aging. Depletion of senescent cells benefits the aging related disease, such as aging bone fracture. However, the molecular mechanisms by which senescent cells regulate their neighboring bone cells are still not well-known. We reported that proteasome inhibitor enhanced fracture repair in aged mice. Senescent cells are major source of chronic inflammatory cytokines, which in turn induced protein ubiquitination. We reported that PDGFRβ was one of the highly ubiquitinated proteins in mesenchymal progenitors (MPCs) and TGFβ was the most increased SASP. In the current study, we found TGFβ induced PDGFRβ ubiquitination and proteasomal degradation through its E3 ligases. TGFβ neutralizing antibody blocked the inhibited callus derived MPC growth and increased Ub-PDGFRβ by senescent cells, which could be further prevented PDGFRβ inhibitor. These findings suggested senescent cells derived TGFβ impaired fracture repair in aged mice through elevating ubiquitination of PDGFRβ. The discovery of TGFβ-PDGFRβ pathway triggered by senescent cells opens avenues for optimizing treatment strategies for aging related disease by combination with the ligand of PDGFRβ.