A multisynaptic pathway from the piriform cortex to the spleen drives learned fear avoidance behaviour in mice.

Examination of human brain tissue infiltrated by gliomas of different clinical grades indicates that heightened neuron–glioma synapse activity drives increased proliferation in high-grade gliomas.

In mice, the sensory neurons that innervate the skeleton signal via FGF9 to promote bone repair after fracture.

Single-nucleus sequencing reveals age- and disease-related changes in the molecular regulation of neurogenesis associated with cognitive decline and resilience.

Two studies use single-nucleus multiomic sequencing to profile molecular and cellular dysfunction in the prenatal and early postnatal cortex in Down syndrome.

Head-direction cells act as a stable ‘neural compass’ as bats navigate across a large natural outdoor environment.

A study explores the circuits through which the dorsolateral prefrontal cortex orchestrates social competition in mice.

The facial movements of mice provide a noninvasive readout of the 'hidden' cognitive processes taking place during decision-making.

Neuroinflammatory mechanisms drive cognitive impairments in mice treated with chimeric antigen receptor (CAR)-T cell therapy.

Single-nucleus RNA sequencing reveals early cellular responses in young atheletes exposed to repetitive head impacts that may lead to neurodegeneration.

Blood pressure pulsations modulate the activity of neurons in the rodent olfactory bulb via the mechanosensitive ion channel PIEZO2

Cerebellar Purkinje neurons modulate thirst in mice

Two studies use large-scale genome sequencing data to identify variants in a noncoding gene that cause a neurodevelopmental syndrome in many individuals.

A subset of female mice that show anxiety-related traits seek out a starvation-like state when exposed to repeated stress

ILC2s promote inhibitory synapse formation in the postnatal mouse brain through the production of IL-13.

Manipulating the synaptic strength of cortical neurons alters sleep pressure in mice.

The organization and diversity of neuronal and glial primary cilia and their connectivity in the human cortex is characterized in detail.

Blocking voltage-gated calcium channels reduces capillary narrowing by pericytes and improves cerebral blood flow in a mouse model of Alzheimer disease.

Thyroid hormone induces cortical circuit plasticity to modulate exploratory behaviours in mice.

A study maps the effects of ageing and sex on gene regulation in specific human cortical cell types.