Objective:To investigate whether there are differences in clinical pregnancy and perinatal outcomes among different protocols for artificial insemination by donor (AID) in female patients aged ≤35 years.Methods:This retrospective cohort study analyzed clinical data of patients who underwent AID at the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University from January 1, 2016 to January 31, 2021. Based on ovulation induction therapy, patients were divided into 4 groups: natural cycle (NC) group, letrozole (LE)/clomiphene (CC) group, gonadotropin (Gn) group and LE/CC combined with Gn (LE/CC+Gn) group. The clinical outcomes, incidence of complications, and offspring health were compared among these groups, and logistic regression analysis was employed to investigate the effects of different protocols on the clinical and perinatal outcomes of AID cycles.Results:In NC group, LE/CC group, Gn group and LE/CC+Gn group, the cycle cancellation rate [0.5% (11/2 147), 1.1% (12/1 045), 1.6% (9/549), 3.2% (9/315), P<0.001], the clinical pregnancy rate [31.5% (673/2 136), 35.8% (370/1 033), 42.8% (231/540), 38.2% (117/306), P<0.001], the multiple pregnancy rate [0.7% (5/673), 3.2% (12/370), 3.5% (8/231), 6.8% (8/117), P<0.001], the abortion rate [12.8% (86/673), 9.2% (34/370), 5.2% (12/231), 8.5% (10/117), P=0.008] and the live birth rate [27.2% (581/2 136), 31.4% (324/1 033), 40.0% (216/540), 34.3% (105/306), P<0.001] were statistically significant, while the differences among the four groups in the ectopic pregnancy rate, the preterm birth rate, and the overdue birth rate were not statistically significant (all P>0.05). After adjusting for confounding factors, the differences were not statistically significant in all indicators compared with the NC group (all P>0.05), except for the miscarriage rate in the LE/CC+Gn group, which was significantly higher than that in the NC group (a OR=2.141, 95% CI: 1.12-4.09; P=0.021). For patients who have been using the same treatment protocol, the cumulative pregnancy rate and the cumulative live birth rate in the NC group and the LE/CC group increased with the increase of assisted reproductive cycles, and the difference was statistically significant (all P<0.001). Regardless of whether confounding factors were adjusted, there were no statistically significant differences in neonatal mortality rate, low birth weight rate, normal birth weight rate, macrosomia rate, and male-to-female ratio among the groups (all P>0.05). Conclusion:In AID cycles with female patients aged ≤35 years, stimulated cycles had similar pregnancy outcomes to natural cycles and did not increase the risk of adverse neonatal outcomes or multiple pregnancies. Choosing the LE/CC stimulation protocol can improve the cumulative pregnancy rate of patients with abnormal ovarian follicle development or ovulation function.

目的 探讨人文关怀在生殖中心患者妊娠率中的影响研究.方法 选取生殖中心收治的行体外受精—胚胎移植的不孕症患者980例临床资料,随机分为干预组与常规组各490例,常规组应用传统护理方式,干预组给予常规组的基础之上,予以人文关怀护理,观察两组护理满意度、妊娠率数据指标,并采用统计学处理方法对两组各项数据指标结果进行统计学处理分析.结果 根据两组观察指标数据结果显示,干预组患者的护理满意率96.73％、妊娠率68.97％均优于常规组的护理满意度75.71％、妊娠率50.40％,且两组数据对比结果,差异具备统计学意义(P＜0.05).结论 在生殖中心的护理工作中应用人文关怀,可以提高患者的护理满意率和妊娠率,从而提高整体护理质量.

目的:探讨来曲唑(LE)促排周期在排卵障碍或月经不规律患者冻融胚胎移植(FET)内膜准备中的临床效果.方法:回顾分析2015年1月至2016年12月首次行FET的排卵障碍或月经不规律患者的临床资料.根据内膜准备方案分为两组:LE组(213例),激素替代周期组(HRT组)(1934例).首次HRT周期助孕失败尚有冻胚的241例患者行再次FET,其中35例采用LE周期(35例),206例仍采用HRT周期.比较各组患者的一般资料和生殖相关参数间的差异.结果:LE组的移植日内膜厚度[(9.49±1.97)mm]高于HRT组[(8.85±2.18)mm],胚胎种植率(45.4％)和活产率(42.7％)高于HRT组(37％和35.9％),流产率(11.2％)低于HRT组(18.9％),差异均有统计学意义(P<0.05).前次HRT周期助孕失败再次FET患者中,采用LE周期和HRT周期患者的一般资料与临床妊娠结局比较,差异均无统计学意义(P>0.05).结论:首次FET患者LE促排周期的临床妊娠结局优于HRT周期;前次HRT周期失败的患者改用LE促排周期未见明显优势,LE促排卵内膜准备可作为排卵障碍或月经不规律患者FET内膜准备的有效候选方案.