The deliberation-based two-pass model that combines both semantic and acoustic information can effectively improve the performance of end-to-end (E2E) spoken language understanding (SLU). However, existing two-pass models usually simply fuse speech embedding and text embedding without taking into account the inherent distinctions between these two modalities. We propose a novel approach named Cross-modal Semantic Alignment before Fusion (CSAF), which adopt contrastive loss aligning speech and text embeddings before fusing them. We introduce a shared semantic memory transformer to project the embeddings from two modalities into a common semantic space, and a multi-modal gated network to generate the fused embeddings. We conduct experiments on the FSC Challenge test set and SLURP dataset. The results demonstrate that our method can significantly promote intent classification accuracy, achieving an absolute improvement of 3.1% over previous works in the FSC Challenge Utterance Set.

目的 探讨对于不稳定型心绞痛患者递增式康复护理路径实施对其PCI术后康复的影响.方法 以我院2019年12月至2021年8月期间收治的88例不稳定型心绞痛患者为例,均采用PCI术进行治疗,按照入院时间分成常规甲组、递增式乙组,各44例,对两组生活质量、运动耐力进行观察.结果 护理后,递增式乙组6MWT优于常规甲组,SF-36评分、心绞痛稳定状态评分高于常规甲组,不良心血管事件率低于常规甲组,差异有统计学意义(P＜0.05).结论 为采用PCI术治疗的不稳定型心绞痛患者,实施递增式康复护理路径,可提升患者生活质量及运动耐力,减少不良心血管事件,加快心脏康复.

目的:比较拮抗剂灵活方案中促黄体生成素(LH)一过性早期升高(早升)和未出现LH早升对新鲜周期体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)患者的妊娠结局,探讨一过性LH早升是否对妊娠结局有不良影响.方法:回顾性分析行拮抗剂灵活方案促排卵的145例IVF/ICSI-ET患者的临床资料.根据LH是否出现一过性早升分为无LH早升组(n=105)和LH早升组(n=40).比较2组患者基本情况、促排卵情况、实验室指标及临床妊娠结局等指标.结果:2组患者平均年龄、不孕年限、体质量指数(BMI)、基础卵泡刺激素(FSH)水平、基础LH水平、基础雌二醇(E2)水平、抗苗勒管激素(AMH)水平、基础窦卵泡(AFC)数、卵巢低储备患者百分率和多囊卵巢综合征(PCOS)患者百分率比较差异均无统计学意义(P>0.05).LH早升组患者添加拮抗剂日的促性腺激素(Gn)天数、添加拮抗剂日LH水平和添加拮抗剂日E2水平均大于无LH早升组(t=-3.251,P=0.001;t=-10.198,P<0.001;t=3.233,P=0.002),而拮抗剂使用天数少于无LH早升组(t=3.090,P=0.003).2组患者添加拮抗剂日卵泡直径、扳机日E2和孕酮(P)水平、扳机日子宫内膜厚度、获卵数、成熟卵数(率)、正常受精数(率)、第3天(D3)可用胚胎数(率)、D3优质胚胎数(率)、胚胎种植率、临床妊娠率及继续妊娠率组间比较差异无统计学意义(P>0.05).多因素Logistic回归分析,添加拮抗剂的Gn天数和添加拮抗剂当日E2水平是采用新鲜IVF/ICSI-ET周期拮抗剂灵活方案中患者出现LH早升的危险因素[OR(95％CI)=1.516(1.128～2.038),P=0.006;OR(95％CI)=2.424(1.345～4.371),P=0.003].结论:采用拮抗剂灵活方案患者在超促排卵过程中出现一过性的LH早升不影响妊娠结局,但需要及时控制升高的LH并注意添加拮抗剂的时机.

目的 探讨基于积极心理学的正念情绪护理在老年冠心病患者中的应用价值.方法 选取2021年1-11月在我院就诊的老年冠心病患者74例,采取抽签法将其分为对照组和观察组,每组各37例,对照组采取常规护理,观察组采取基于积极心理学的正念情绪护理,比较两组患者的负面心理状况、睡眠情况以及患者的生活质量水平.结果 经干预后观察组患者的焦虑、抑郁评分相较于对照组患者而言更低(P＜0.05);观察组患者的睡眠质量评分优于对照组(P＜0.05);观察组患者的生活质量评分优于对照组(P＜0.05).结论 基于积极心理学的正念情绪护理干预可有效减轻老年冠心病患者的负面情绪,使患者的睡眠质量与生活质量得到提高.

In comparison to mouse, the developmental process of human islets has not been properly elucidated. The advancement of single cell RNA-seq technology enables us to study the properties of alpha and beta cells at single cell resolution. By using mitochondrial genome variants as endogenous lineage-tracing markers, we found that human alpha and beta cells have different lineage features. This finding suggests specific endocrine progenitors for alpha and beta cells, which is different from mouse islet cells. This strategy was also applied to a study of chemically-induced islet cell reprogramming and was used to help identify artemether-induced alpha-to-beta trans-differentiation in human islets. The computational results of this study will inspire future studies to establish, maintain, and expand beta cell-specific progenitors in vitro and in vivo.

License plate recognition is a very important component of intelligent parking lot management systems. The accuracy and speed of license plate recognition directly affect the speed of vehicles entering and leaving a parking lot. According to the characteristics of the character composition of a license plate, based on the convolutional neural network model LeNet-5, the license plate character recognition network model is designed. After training to the model, the recognition accuracy of each character in the license plate is higher than 99.97

Objective To explore the application of progestin-primed ovarian stimulation protocol in patients with repeated in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) failure undregoing conventional controlled ovarian hyperstimulation (COH). Methods The clinical data of 76 patients from January 2017 to December 2018 in Reproductive Center of the First Affiliated Hospital of Xiamen University with normal ovarian reserve who failed to get pregnancy with long protocol and gonadotropin-releasing hormone (GnRH) antagonist protocol, adopting long protocol or GnRH antagonist protocol again or administered with progestin-primed ovarian stimulation (PPOS) protocol followed by frozen-thawed embryo transfer (FET), were analyzed retrospectively. They were divided into two groups: conventional COH protocol group (group A, n=46), PPOS group (group B, n=30) according to different protocols. The clinical indicators, laboratory indicators and clinical pregnancy outcomes were compared between the two groups. Results The general conditions of patients in groups A and B were comparable. The normal fertilization rate (78.3%), available embryo rate (69.5%) and cumulative pregnancy rate (60.0%) in group B were higher than those in group A (70.3%, P=0.031; 57.9%, P=0.017; 34.8%, P=0.031). The difference was statistically significant. The high-quality embryo rate (52.4%) in group B was slightly higher than that in group A (48.0%) with no statistical significance (P=0.061). There were no significant differences between the two groups in the total amount of gonadotropin (Gn), the duration, estradiol level on human chorionic gonadotropin (hCG) injection day, amount and rate of MII oocytes, the number of two pronucleus (2PN) embryos, the cleavage rate, the implantation rate, the clinical pregnancy rate, and the early abortion rate (P>0.05). Conclusion For the patients with normal ovarian reserve function who failed to get pregnancy repeatedly with conventional COH protocols, PPOS protocol can improve the normal fertilization rate, the available embryo rate and the cumulative pregnancy rate, and may increase the high-quality embryo rate and eventually improve clinical pregnancy outcome. PPOS protocol provides a new way for these patients to choose COH protocol thirdly. Key words: Progestin-primed ovarian stimulation; Controlled ovarian hyperstimulation; Ovary reserve; Fertilization in vitro; Intracytoplasmic sperm injection; Repeated failure

目的:探讨降调节后联合激素替代和单纯激素替代2种内膜准备方法对高龄不孕患者冻融胚胎移植(FET)妊娠结局的影响,分析降调节后激素替代FET周期临床妊娠结局的影响因素,为高龄不孕患者冻融胚胎移植周期内膜准备方案的选择提供依据.方法:选择年龄≥35岁首次行FET高龄不孕患者211例,按子宫内膜准备方案分为降调节后激素替代周期组(n=114)和激素替代周期组(n=97).回顾性分析2组患者年龄、不孕年限、体质量指数(BMI)、抗苗勒管激素(AMH)水平、基础性激素、转化日内膜厚度、移植胚胎数、移植优质胚胎数、移植优质胚胎率、多胎妊娠率、临床妊娠率和流产率,并对高龄不孕患者降调节后激素替代周期的妊娠结局影响因素进行二项Logistic回归分析.结果:2组患者年龄、不孕年限、BMI、AMH、移植胚胎数、移植优质胚胎数、移植优质胚胎率、多胎妊娠率和流产率比较差异无统计学意义(P＞0.05).降调节后激素替代周期组患者临床妊娠率及胚胎着床率均明显高于激素替代周期组(x2=9.964,P＜0.05;x2=9.964,P＜0.05).二项Logistic回归分析,患者年龄(OR=0.805, 95％ CI:0.697～0.930)和移植优质胚胎数(OR=4.098,95％CI: 1.597～10.514)是影响高龄不孕患者降调节后激素替代周期妊娠结局的关键因素.结论:采用降调节后激素替代周期的高龄不孕患者在FET中能得到更好的临床结局,年龄和移植优质胚胎数是影响高龄不孕患者降调节后激素替代周期妊娠结局的关键因素.

In article number 1804890, Zhi Zhu and co-workers realize visual quantitative detection of circulating tumor cells (CTCs) using a portable volumetric bar chart chip (V-Chip) with singlecell sensitivity. The target CTCs are labeled with aptamer conjugated nanoparticles that can catalyze the generation of oxygen for the movement of an ink bar in the V-Chip. The CTC number is quantified by the distance of the ink bar visually. This portable detection method shows great potential for quantification of rare cells with single-cell sensitivity for various applications.

Objective To evaluate the clinical pregnancy outcomes of in vitro fertilization (IVF) cycles undergoing gonadotropin-releasing hormone agonist (GnRH-a) or gonadotropin-releasing hormone antagonist (GnRH-A) protocols in different progesterone concentration intervention in late follicular phase.Methods In this retrospective study,the data of 352 IVF GnRH-a and 277 IVF GnRH-A cycles were performed in Reproductive Medical Center of the First Affiliated Hospital of Xiamen University from June 2015 to December 2017.According to the different concentration of progesterone intervention on human chorionic gonadotropin (hCG) injection day,patients were divided into four subgroups (group A,progesterone ＜ 1.2 μg/L;group B:1.2 μg/L ≤ progesterone ＜l.5 μg/L;group C:1.5 μg/L ≤ progesterone ＜1.75 μg/L;group D:progesterone ≥ 1.75 μg/L.The clinical pregnancy rate and the abortion rate were compared among the above groups in which patients received day 3 or day 5 embryos transplanted.Results The clinical pregnancy rates of the four groups (A-D) undergoing GnRH-a protocol were 55.00％ (110/200),54.17％ (39/72),52.00％ (26/50),and 30.00％ (9/30),and those undergoing GnRH-A protocol were 50.71％ (71/140),48.61％ (35/72),35.00％ (14/40),and 20.00％ (5/25),respectively.The clinical pregnancy rates of both group D undergoing different protocols were significantly lower than other progesterone intervention groups (P＜0.05).The clinical pregnancy rates undergoing GnRH-A protocol were significantly decreased in group C (P＜0.05).The lowest clinical pregnancy rate was 16.67％ in group D undergoing GnRH-A protocol with day 3 embryo transplanted,significantly lower than other subgroups.The clinical pregnancy rates undergoing GnRH-a protocol with day 3 embryo transplanted were significantly decreased when progesterone concentration elevated to the level of group C (group C vs.groups A,B:44.00％ vs.50.00％,50.00％).Conclusion The clinical pregnancy outcomes were significantly decreased when the late follicular progesterone intervention elevated to 1.75 μg/L in those patients undergoing GnRH-a protocol,but in this group with day 3 embryo transplanted,the clinical pregnancy rate was already significantly decreased when progesterone levels elevated to 1.5 μg/L.The clinical pregnancy rates in patients undergoing GnRH-A protocol were also significantly decreased when progesterone intervention elevated to 1.5 μg/L.In this same group with day 3 embryo transplanted,the clinical pregnancy rate was decreased when progesterone levels elevated to 1.2 μg/L although without significant differences.

Objective To investigate the social characteristics and psychological status of advanced age infertile women before entering assisted reproductive technology. Methods A total of 177 infertile women aged 35 years or older planning for assisted reproductive technology in Assisted Reproductive Center of the First Affiliated Hospital of Xiamen University from January 2017 to March 2018 were included in this study. Questionnaire including editing general condition questionnaire, Zung self-rating anxiety scale (SAS) and Zung self-rating depression scale (SDS), were collected to evaluate psychological state of these patients before entering assisted reproductive technology. Results Advanced age infertile women were with high rates of anxiety and depression detection. According to χ2 test, high income, educational background, stable work, remarriage and nullipara were more urgent requirements for children, the rates of depression and anxiety detection were significantly increased (P<0.05). The high risk factors that affect anxiety are age (OR=1.178, P=0.012), economic income (OR=6.706, P=0.003), occupation (OR=3.624, P=0.033), marital status (OR=16.065, P=0.003), and birth situation (OR=9.937, P<0.001) through binary logistic regression. The high risk factors that affect depression are age (OR=1.213, P=0.007), economic income (OR=6.436, P=0.007), occupation (OR=5.128, P=0.013), marital status (OR=15.408, P=0.005) and birth situation (OR=22.118, P<0.001) through binary logistic regression. Conclusion Infertile women are less aware of the risks of childbirth at an advanced age, especially after pregnancy and during childbirth. Before assisted reproduction technology treatment, anxiety and depression symptoms are widespread, especially with the high risks of advanced age, stable work, low income, remarried and childless. More attention should be paid to the mental health status of the advanced age infertile women who are assisted reproductive therapy, and more education should be given to the knowledge of reproduction at the old age. Key words: Advanced age; Infertility; Assisted reproductive technology; Depression; Anxiety

深部侵袭性血管粘液瘤为一种极罕见的肿瘤. 1983年,由Steeper、Rosai等[1]首次命名,1994年,WHO把它归类为软组织的良性肿瘤, 2003年 WHO又称其为深部血管粘液瘤.其具有生长缓慢,侵袭性,易复发的特点. 自1983年以来,国内外的报道不多,而外阴部侵袭性粘液瘤的报道更为罕见,近期本科收治1例,患者病情状况良好,现报道如下.

目的 研究多囊卵巢综合征不孕症患者采取二甲双胍与炔雌醇环丙孕酮治疗的价值.方法 便利选择该院2017年7月—2018年5月纳入的100例多囊卵巢综合征不孕症患者,随机分为研究组与对照组,各50例,研究组采取二甲双胍与炔雌醇环丙孕酮,对照组采取炔雌醇环丙孕酮,对比两组治疗结果 及对患者体内激素水平、妊娠率的影响.结果研究组总有效率92.00％高于对照组80.00％,差异有统计学意义(x2=5.980,P<0.05);且治疗后研究组各指标水平低于对照组,差异有统计学意义(P<0.05);研究组排卵率、妊娠率均显著高于对照组,差异有统计学意义(P<0.05),流产率低于对照组,差异有统计学意义(P<0.05).结论 多囊卵巢综合症不孕症患者采取炔雌醇环丙孕酮与二甲双胍效果明显,能有效改善患者体内激素水平促进排卵,提高妊娠率,降低流产率.

Objective To explore the effect of estradiol valerate combined with clomiphene on endometrial thickness and serum estradiol (E2) and progesterone levels in patients with infertility caused by ovulatory disorder,provide a reference basis for clinical treatment. Methods From December 2013 to August 2016,96 patients with infertility caused by ovulatory disorder were selected and divided into observation group and control group according to random number table,48 patients in each group. The patients in control group were treated with clomiphene,and the patients in observation group were treated with estradiol valerate combined with clomiphene. Endometrial thicknesses and the levels of serum sex hormones[E2,progesterone,luteinizing hormone (LH),follicle-stimulating hormone (FSH) ]before and after treatment in the two groups were compared. The patients in the two groups were followed up for three months. Ovulation rates and pregnancy rates in the two groups were compared. Results Before treatment,there was no statistically significant difference in endometrial thickness between the two groups (P＞0. 05). After treatment,endometrial thicknesses in the two groups increased significantly,endometrial thickness in observation group was statistically significantly thicker than that in control group (P＜0. 05). Before treatment,there was no statistically significant difference in the levels of serum FSH,LH,E2,and progesterone between the two groups (P＞0. 05). After treatment,the levels of serum E2and progesterone in observation group were statistically significantly higher than those in control group (P＜0. 05); there was no statistically significant difference in the levels of serum FSH and LH between the two groups (P＞0. 05). The incidence rates of adverse reactions in observation group and control group were 14. 58％ (7/48) and 10. 42％ (5/48),respectively,There was no statistically significant difference in the incidence rates of adverse reactions between the two groups (P＞0. 05). After treatment, the ovulation rates in the two groups were 85. 42％ (41/48) and 70. 83％ (34/48),respectively,there was no statistically significant difference in ovulation rate between the two groups (P＞0. 05),pregnancy rate in observation group was statistically significantly higher than that in control group (P＜0. 05). Before treatment,there was no statistically significant difference in SAS and SDS scores between the two groups (P＞0. 05). At three months after treatment,SAS and SDS scores in observation group were statistically significantly lower than those in control group (P＜0. 05). Conclusion The clinical effect of estradiol valerate combined with clomiphene in treatment of patients with infertility caused by ovulatory disorder is significant,the therapy can effectively increase endometrial thickness,improve the levels of se-rum E2,progesterone and pregnancy rate,relieve negative emotions with a certain safety.

目的 探讨密闭式培养系统对胚胎发育及子代小鼠学习和记忆能力的影响.方法 建立胚胎密闭式培养体系,分组为密闭培养组和常规培养组(对照组),比较两种培养方式小鼠胚胎的发育和着床情况;Morris水迷宫实验和小鼠跳台实验研究两种培养方式获取的胚胎移植后新生小鼠学习和记忆能力.结果 密闭培养组小鼠胚胎发育和着床能力与常规培养组相比无显著差异(P＞0,05);Morris水迷宫和小鼠跳台实验结果显示,密闭培养组小鼠胚胎移植后新生小鼠学习和记忆能力与常规培养组无显著差异(P＞0.05).结论 密闭培养体系培养的胚胎与常规培养得到的胚胎相比,在胚胎质量、着床能力以及子代小鼠学习和记忆能力方面均无统计学差异.

Objective:To compare the clinical outcomes of selective single blastocyst transfer(eSBT)with double blastocysts transfer(DBT)in fresh embryo transfer cycles among infertile women with normal ovarian reserve.Methods:A retrospective study including 210 women with normal ovarian reserve undergone fresh embryo transfer cycles,who were transferred at least one blastocyst in good quality,was conducted in our center from January 2014 to December 2015.The patients were categorized into two groups according to the number of blastocyst transferred as follows:eSBT group(n=127)and DBT group(n=83).The outcomes of pregnancy and newborn were compared between the two groups.Results:There were no significant differences in ovulation status,incidence of moderate or severe OHSS,embryo formation,clinical pregnancy rate,abortion rate,ectopic pregnancy rate,live birth rate,monozygotic twin rate and infant malformation rate between the two groups(P＞0.05).The multiple birth rate(1.08％ vs.49.21％),the late abortion rate(0％ vs.7.94％),preterm birthrate(3.75％ vs.20.37％),the rate of low birth-weight infants(6.17％ vs.30.38％)in eSBT group were significantly lower than those of DBT group(P＜0.05).However,the implanting rate(73.23％ vs.61.45％)and the average neonatalweight [(3 160.06±441.94)g vs.(2 735.39±555.08)g] in eSBT group were significantly higher than those of DBT group(PΙ0.05).Conclusions:For patients under 40 years with normal ovarian reserve who had at least one goodquality blastocyst in fresh embryo transfer cycles,the selective single good quality blastocyst transfer should be given priority to consideration.

How to extract image features highly correlated with visual perception is still a challenging task in No-reference image quality assessment. We aim to test the feasibility of introducing deep learning into quality assessment algorithm. In this paper, we developed a novel convolution neural network IQF-CNN that is able to learn more discriminative image quality features, and applied the learned features to predict image quality. We also used the local luminance coefficients normalization and dropout technology to improve the IQF-CNN learning ability. The proposed method can accurately measure the five common image distortions on standard benchmarks, and also improvements over the previous state of the art NR-IQA works have been demonstrated.

目的 探讨低促性腺激素性闭经致不孕不育患者的临床治疗方法 .方法选取我院2013年8月—2016年8月收治的46例低促性腺激素性闭经致不孕不育患者进行研究,随机将患者分为观察组、对照组各23例.对照组接受常规治疗,观察组采用人工周期、人绒毛膜促性腺激素以及尿促性腺激素进行治疗.对比2组患者的治疗总有效率、子宫体积、卵巢体积、子宫内膜厚度以及妊娠率.结果 观察组患者的治疗总有效率(95.65%)、子宫体积、卵巢体积、子宫内膜厚度以及妊娠率(86.96%)均优于对照组差异具有统计学意义(P<0.05).结论 应用人工周期、人绒毛膜促性腺激素以及尿促性腺激素治疗低促性腺激素性闭经致不孕不育患者,具有良好的临床效果.

目的:探究腹腔镜联合宫腔镜用于治疗不孕不育症的临床疗效.方法:选本院2013年2月-2014年2月收治的90例不孕不育症患者,按随机数字表法随机划分为两组,每组45例,对照组患者治疗方式为传统开腹手术,观察组患者治疗方式为腹腔镜与宫腔镜联合手术,比较两组治疗效果.结果:观察组治疗有效率为93.33%,明显高于对照组的73.33%,差异有统计学意义(P<0.05);术后随访2年,观察组妊娠率与分娩率分别为80.00%、75.56%,明显高于对照组的57.78%、51.11%,差异有统计学意义(P<0.05).结论:联合应用腹腔镜与宫腔镜手术治疗不孕不育症可提高临床疗效,且预后佳,推荐推广.

Scene text recognition is a hot topic in the field of computer vision. Inspired by the success of the Single Shot Multibox Detection (SSD) on generic object detection, the architecture of SSD is implemented on scene text detection. SSD does not do well on text detection, because scene text as an object is usually smaller than a generic object and SSD cannot detect small objects well. Thus, the statistic analysis for scene text is made. Based on statistic characteristics of scene text, we propose a method named Text-SSD to detect scene text. Moreover, in order to boost the detection accuracy, multi-scale image are used to learn the multi-scale models. The voting based non-maximum suppressing is made for a candidate text region. The experimental results show that our method achieved the state-of-the-art performance on the benchmark dataset ICDAR2013 in the detection accuracy. Moreover, when using a single model, our method achieves the fastest speed compared with several latest text detection method based on deep neural network. Thus, experimental results demonstrate our method is efficient on scene text detection.