Objective : To investigate the expressions and clinical significance of C-X-C motif chemokine ligand 11（CXCL11） and C-X-C motif chemokine receptor 3（CXCR3） in oral squamous cell carcinoma（OSCC） tissue. Methods : We downloaded the GSE30784 dataset in the Gene Expression Omnibus（GEO） database to screen differentially expressed genes for GO enrichment analysis. 67 cases of OSCC tissue with different degrees of differentiation and 28 cases of normal oral mucosal tissue were collected. The expressions of CXCL11 and CXCR3 proteins were detected by immunohistochemistry. The relationship between CXCL11/CXCR3 expression and the clinicopathological features of OSCC, and the correlation between CXCL11 and CXCR3 expressions were analyzed. And the relationship between CXCL11/CXCR3 expression and survival was analyzed based on follow-up data. Results : GEO dataset analysis showed that CXCL11 expression was significantly up-regulated in OSCC tissue（LogFC = 3.545, P ＜ 0.001）; GO enrichment analysis found that CXCL11 was enriched in tumor cell invasion and migration. The positive expression rates of CXCL11 and CXCR3 in OSCC tissue were 68.7% and 74.6%, respectively, which were significantly higher than those in normal oral mucosal tissue（P ＜ 0.05）. The expressions of CXCL11 and CXCR3 in OSCC were related to the degree of differentiation, clinical stage and lymph node metastasis（r = 0.271,P = 0.05）, and did not affect age, sex or tumor diameter（P ＞ 0.05）. The expressions of CXCL11 and CXCR3 in OSCC might be correlated（P ＜ 0.05）; In OSCC patients, the survival time of CXCL11-and CXCR3-positive groups might be shorter than that of CXCL11-and CXCR3-negative groups（P ＜ 0.05）. Conclusion : The over-expressions of CXCL11 and CXCR3 in OSCC may participate in the occurrence and development of OSCC, and lead to poor prognosis, which provides new evidence for early diagnosis, prognosis assessment and targeted treatment of OSCC.

Objective To explore the relationship between the IL-6 in the gingival crevicular fluid (GCF) of the chronic periodontitis (CP) and the depression-anxiety psychological factors. Methods The CP group involved 35 patients while 34 periodontol health volunteers were enrolled as control group. The questionaires of the Self-rating anxiety scale(ASA) and the center for epidemiologic studies depression scale (CES-D) were taken, then the GCF was collected and received the clinical periodontol examination. The amount of IL-6 in the GCF was surveyed by the radio-immunoassay method. Results The amount of IL-6 in the GCF of the control group was (0.16±0.04) ng, while that of the CP was (0.28±0.02) ng. The difference between the CP and the control group was statistically significant (P 0.001). In the linear regression equation of the IL-6 and the depressive psychological factor got F = 7.430, P = 0.009; The linear regression equation of the IL-6 and the anxiety psychological factor got F = 7.150,P = 0.010. Conclusion The chronic periodontitis get the higher amount of IL-6 of the GCF, compared with the anxiety psychological factor, the depression psychological factor get closer correlation with the IL-6 within CP.