The FDA is considering authorizations for Pfizer’s paxlovid and Merck & Co.’s molnupiravir, the first two oral COVID-19 antivirals.
Discover the world’s best science and medicine | Nature.com
Discover the world’s best science and medicine | Nature.com
Discover the world’s best science and medicine | Nature.com
Discover the world’s best science and medicine | Nature.com
Discover the world’s best science and medicine | Nature.com
Discover the world’s best science and medicine | Nature.com
Despite a regulatory setback for Provention Bio’s diabetes prevention candidate teplizumab, hopes remain high for T cell-regulating therapies in autoimmune indications including multiple sclerosis, systemic lupus erythematosus and coeliac disease.
The authors of this study designed a novel therapeutic class of antimicrobials in which they optimized drug binding and permeation of the drug through bacterial membrane transporters simultaneously.
Li, Xiao and colleagues show that antihistamines might increase the efficacy of immune checkpoint blockade.
Discover the world’s best science and medicine | Nature.com
Enhanced levels of the pro-inflammatory lipid prostaglandin E 2 (PGE 2 ) in the ageing immune system cause metabolic changes in macrophages and microglia that are associated with chronic inflammation and impaired cognition. Inhibition of the PGE 2 receptor was shown to reduce brain inflammation and restore memory in mice.
Discover the world’s best science and medicine | Nature.com
Exosomes — small extracellular vesicles that are shed by cells — have long offered promise as drug delivery systems for small molecules, DNA, RNA and other biologic payloads. The first of these are now in the clinic. Exosomes — small extracellular vesicles that are shed by cells — have long offered promise as drug delivery systems for small molecules, DNA, RNA and other biologic payloads. The first of these are now in the clinic.
Discover the world’s best science and medicine | Nature.com
J&J's phase II trial of an immunomodulator for depression could inform the development of stratified medicine in psychiatry. J&J's phase II trial of an immunomodulator for depression could inform the development of stratified medicine in psychiatry.
Discover the world’s best science and medicine | Nature.com
Julian Downward合作论文数Oncogene Biology Laboratory, The Francis Crick Institute4
Sally J. Leevers合作论文数4
Tak Mak (麦德华)合作论文数Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto;Department of Pathology, School of Clinical Medicine, University of Hong Kong3
Mary Wu合作论文数Francis Crick Inst, High Throughput Screening, London NW1 1AT, England2Thomas Porstmann合作论文数1Nic Tapon合作论文数1Julie Bastien合作论文数1
Ditte Skovaa Andersen合作论文数Department of Biology, Faculty of Science, University of Copenhagen1Beatrice Griffiths合作论文数Inst Canc Res, Ctr Evolut & Canc, Translat Oncogen Lab, 237 Fulham Rd, London SW3 6JB, England1
Tao Liu合作论文数1
Vuk Stambolic合作论文数Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto1
Han You (尤涵)合作论文数School of Life Sciences, Xiamen University1
Buzz Baum合作论文数Medical Research Council Laboratory for Molecular Cell Biology, Faculty of Life Sciences, University College London1
Cláudio Santos合作论文数Dept. of Production & Syst., Univ. of Minho;c;Dept. of Production & Syst., Univ. of Minho1Piekorz Roland P合作论文数Univ Dusseldorf, Univ Hosp & Clin1Caroline Treins合作论文数1
John Griffiths合作论文数Cancer Research UK Cambridge Institute, University of Cambridge;Department of Radiology, University of Cambridge1
Ming-Sound Tsao合作论文数Princess Margaret Cancer Centre;Department of Laboratory Medicine and Pathobiology, University of Toronto;Department of Medical Biophysics, University of Toronto1
Almut Schulze合作论文数Division of Tumor Metabolism and Microenvironment, Deutsches Krebsforschungszentrum;German Cancer Research Center;Medical Faculty, Ruprecht-Karls University1
Arnold J. Levine合作论文数The Simons Center for Systems Biology, Institute for Advanced Study;School of Natural Sciences, Institute for Advanced Study1
Tony Pawson (安东尼·鲍森)合作论文数Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto1A. Genevet合作论文数1Andrew Elia合作论文数University of Toronto;University Health Network1
Susan Done合作论文数Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto1Patricia H. Warne合作论文数1
William Muller合作论文数Rosalind and Morris Goodman Cancer Institute, Faculty of Medicine and Health Sciences, McGill University;Department of Biochemistry, School of Biomedical Sciences, McGill University1Yuen-Li Chung合作论文数CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research1
