Defective mitochondrial metabolism results in dysfunction CD8 + T cells in chronic viral infections and tumours.

Production of neurotrophic factors by enteric glial cells controls IL-22 production by ILC3s for barrier defence.

ymmetric distribution of metabolic pathway components sustains differential CD8 + T cell fates.

n intronic element of Foxp3 facilitates the selection of T Reg cells with a diverse TCR repertoire for effective self-tolerance.

n interferon-γ-mediated immune response is dominant in severe asthma.

Oestrogen receptor-β promotes immune evasion of endometriotic tissue by blocking TNF-induced apoptosis and enhancing inflammasome activity.

The intestinal epithelial barrier is covered by a thick layer of stratified mucus that physically separates commensal bacteria from the epithelial cells and underlying immune cells. Now, a new study shows that the symbiont Bacteroides thetaiotaomicron releases antigen-containing outer membrane vesicles (OMVs) that traverse these barriers and access intestinal immune cells in a sulfatase-dep… Download references

RIPK1 and NF-κB signalling in dying cells are necessary for CD8 + T cell cross-priming.