Plant-derived self-assembled nanoparticles, especially from food-medicine homology sources, are gaining attention, yet their structure-function relationships remain unclear. This study identified such nanoparticles from leaf decoction of Eucommia ulmoides, a key plant in traditional Asian medicine and diet, termed EUPs. These spherical particles (~287.8 nm) were primarily composed of polysaccharides and polyphenols, with 268 polyphenolic compounds detected via UPLC-QTOF-MS. Stepwise dissociation-ultrafiltration and spectroscopic analyses revealed that polyphenols were bound to the polysaccharide through noncovalent interactions, including hydrogen bonding and hydrophobic forces, forming a layered structure with sustained-release and thermo-responsive properties. Compared with free polyphenols, EUPs exhibited significantly prolonged anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages, reflected by the suppression of key inflammatory cytokines, including TNF-α, IL-6 and NO. Therefore, it aims to offer mechanistic insights into the multi-component synergistic anti-inflammatory effects of E. ulmoides and supporting the material basis of food-medicine homology.

INTRODUCTION: Coxiella burnetii, the causative agent of Q fever, is a notifiable zoonotic pathogen in Ireland. While typically subclinical in ruminants, infection is associated with reproductive losses. In humans, disease can range from asymptomatic to more serious complications. Ruminants have been identified as the main reservoir for human infection. Ireland’s dairy cattle industry has expanded substantially in recent years, yet current data on the national prevalence of Coxiella burnetii in dairy herds are limited. Understanding the herd-level prevalence and associated risk factors is essential for informing disease management and control strategies. METHODS: Bulk milk tank testing results from an Irish dairy cooperative herd health programme were analysed to determine the apparent and true prevalence of Coxiella burnetii antibodies, using 2022 data. Further analysis was conducted to determine the relationship between Coxiella burnetii prevalence and co-morbid disease and herd characteristics. RESULTS: 2687 dairy herds were included in the sample. The true prevalence of Coxiella burnetii antibodies was 61.7%. Coxiella burnetii prevalence was associated with increasing herd size, whereas higher herd average EBI and lower replacement rates were associated with decreased odds of infection. CONCLUSION: This study provides updated data, revealing the highest herd-level prevalence of Coxiella burnetii antibodies reported to date in Ireland. The association with larger herd size is particularly relevant with the substantial growth in the national dairy herd over the past decade. These findings reinforce the need for further research into transmission dynamics, impact on production and zoonotic risk.

Saudi Arabia is seeking to reposition halal from a label focused on religious permissibility to a broader trust mark that explicitly encompasses food safety, quality and nutrition. This matters because halal markets are expanding globally and because, in many non-Muslim settings, ‘halal’ is still reduced in public discourse to slaughter practices rather than understood as a holistic system of standards.

Bivalves are fast-growing, nutrient-rich, and environmentally sustainable, making them ideal for large-scale aquaculture. The boiling effluent generated during the process of bivalves is often discarded, resulting in a loss of valuable nutrients. This study utilised the clam boiling effluent (CBE) of Corbicula fluminea to harvest a clam protein-polysaccharide extract (CPPE) for enhanced curcumin (Cur) delivery. Among several extraction methods tested, ultrafiltration (UF, 100 kDa MWCO) achieved the highest yield (67%) and produced a uniform extract with a relatively small polydispersity index (PDI) < 0.2, supporting UF as a suitable extraction method. Compositional analysis indicated that the UF-CPPE contained 80.2% polysaccharides and 9.7% proteins. A curcumin-loaded CPPE (CPPE@Cur) delivery system was then fabricated by the solvent displacement-induced self-assembly method, exhibiting concentration-dependent binding, with a maximum encapsulation efficiency exceeding 60% at a CPPE:Cur mass ratio of 35:1. FTIR spectroscopy and interaction analysis suggested that hydrogen bonding and hydrophobic interactions were the main forces driving complex formation. Compared to free curcumin, CPPE@Cur exhibited increases of approximately 350% in photostability and 200% in thermal half-life under common food processing conditions. The system also maintained good colloidal stability after repeated freeze-thaw cycles. In the RAW 264.7 macrophage model, CPPE@Cur significantly enhanced intracellular delivery and antioxidant activity, outperforming both free curcumin and CPPE alone. The results show that bioactive protein-polysaccharide colloidal particles can be efficiently harvested from CBE, offering a sustainable and robust platform for curcumin stabilisation and delivery in functional food applications.

Plant-derived nanoparticles are gaining attention for enhancing the delivery and bioavailability of bioactive compounds, though the mechanisms remain unclear. This study aims to investigate dried hawthorn-derived nanoparticles (DHNPs), focusing on their composition, molecular interactions and impact on polyphenol absorption. The results showed that DHNPs, averaging 275.7 nm, were primarily composed of polysaccharides and high content of polyphenolic compounds (∼25%), with covalent and non-covalent interactions forming between them. Saponification increased the polyphenol release, and metabolomics identified 252 polyphenolic compounds, with 195 showing a relative increase post-treatment, including caffeic acid and (-)-catechin. An in vitro intestinal absorption test using Caco-2 cell monolayer model demonstrated that DHNPs-bound polyphenols exhibited significantly higher permeability (27.90%) compared to free polyphenols (12.38%), indicating that endocytosis may serve as a potential pathway through which DHNPs enhance polyphenol absorption. This study provides new insights into the role of plant-derived nanoparticles contributing to bioactive compound delivery and bioavailability.

BackgroundThe World Health Organization (WHO) announced the end of the emergency phase of Corona Virus Disease 2019 (COVID-19) in May 2023. Nations across the world address the effects of the pandemic and the need to plan for future pandemics. Ireland heavily focused on isolation and social distancing to curb the infection rate early in the pandemic. These long and extended lockdowns gave Ireland a very unique experience during the COVID-19 pandemic.AnalysisIreland’s COVID-19 pandemic management was discussed by an expert panel on the strengths in our national pandemic action plans, areas not sufficiently addressed and requirements to ensure future pandemic preparedness plans are robust.Policy OptionsRecommendations include having a more strategic plan to protect society’s most vulnerable people, a flexible national policy that swiftly implements advances in scientific knowledge and good practices, a robust communication plan including localised information to prevent “pandemic fatigue,” and address challenges from restrictions, lockdowns and isolation such as mental health and wellbeing.ConclusionLessons learnt from the Irish COVID-19 pandemic experience can be utilised for pandemic preparedness plans, nationally and internationally.

Cell-cultured meat, as a novel food, is often met with limited consumer understanding, leading to a predominantly conservative attitude and lower acceptance. To gain insights into the key factors influencing consumer acceptance of cell-cultured meat, this study constructs a moderated mediation model to examine the relationship between food techneophobia (FTN), food disgust sensitivity (FDS), and acceptance of cell-cultured meat. Moreover, we investigate the mediating effects of perceived benefits (PB) and perceived risk (PR), as well as the moderating effect of information acquisition (IA). A field survey was conducted in 2020 with 4,841 Chinese consumers in households. The data were analyzed using partial least squares structural equation modeling (PLS-SEM). The findings reveal that PB is the strongest positive influencing factor of acceptance. FTN has a better predictive effect on acceptance than FDS. Both FTN and FDS can reduce PB and increase PR, thereby lowering acceptance. Partial mediation of PB and PR between FTN and acceptance of cell-cultured meat is observed, while full mediation of PB and PR exists between FDS and acceptance. IA can mitigate the negative impact of FDS on PB, thereby enhancing consumer acceptance of cell-cultured meat. This study contributes to the current literature by employing PLS-SEM as an assessment model for examining direct and mediation relationships. Understanding the factors that shape consumers’ perceptions and influnce their acceptance is essential for effective forecasting and strategic decision-making in the novel food industry.

Abstract Background The COVID-19 pandemic has had huge repercussions for public health internationally and different countries had different outcomes based on preconceived policy interventions. Lessons influencing future policy have been learned, notably how best to manage vulnerable populations, particularly those living in long-term care facilities (LTCFs). In Ireland LTCF residents accounted for 56% of deaths during the first wave of the pandemic and it is imperative to establish the causes of this. International research has highlighted how factors including county incidence rate, facility size, occupancy, LTCF ownership and compliance with health inspection regulations influenced LTCF COVID-19 outcomes. The aim of this research is to explore the impact of these factors in an Irish context and compare to best international standards. Methods The main outcome considered was deaths per 100 beds. Data on crude mortality were available for 580 Irish LTCFs up to 28 May 2020. Data regarding occupancy, ownership, facility size and compliance with regulations were obtained for these LTCFs from a novel dataset of 1130 available LTCF regulatory inspection reports between 2018- 2022. Regression analysis was carried out to show how LTCF mortality was predicted by examined variables. Results The most significant predictor of deaths from COVID-19 in Irish LTCFs resulting from this research was LTCF occupancy (Odds ratio:1.029, significance <0.001). Regional community incidence, in concordance with international literature was also an important factor. Other stated predictors in this model were either non-significant or only marginally significant. These results are analysed in conversation with international research of the same variables. Conclusions To protect LTCF residents for potential future pandemics, attention should be paid to monitoring and suppressing local incidence rates and moves should be implemented towards designing smaller facilities with individual rooms for vulnerable residents. Key messages • Irish long-term care pandemic mortality was predicted by high occupancy of facilities and high regional COVID-19 incidence. • Comparing International COVID-19 outcomes in long-term care facilities can provide guidelines for the future.

Abstract Background Effective public health management during the COVID-19 pandemic requires accurate differentiation between re-infections and residual viral RNA detections in repeat positive cases. This study investigates cycle threshold (CT) trends in repeat SARS-CoV-2 cases to discern between persistent viral remnants and active infections. Collaboration between contact tracing and laboratories is essential for shaping robust public health strategies. Methods A retrospective analysis was conducted on 427 individuals with repeat positive PCR tests. Data was collected at a contact tracing centre from March to August 2021. Key variables including age, gender, and biomedical markers (test intervals, CT values) were examined. Regression and correlation techniques assessed CT trends and their implications. Results Younger individuals (<60 years) occasionally exhibited significantly lower CT values in subsequent tests, suggesting potential re-infections, while older adults generally displayed higher CT values indicative of residual RNA. These age-specific CT trends were statistically significant and instrumental in refining testing protocols and isolation guidelines. Further analysis is expected to strengthen these findings Conclusions Collaborative approaches between contact tracing and laboratories are vital in shaping robust public health strategies for distinguishing between types of repeat infections. Revision of health policies is imperative to prevent unnecessary isolation and optimise healthcare workforce allocation during ongoing transmission periods. Key messages • Decisive decision-making skills are crucial in managing repeat SARS-CoV-2 infections. • Revised health policies align testing and isolation practices with empirical CT data, enhancing public health efficacy.

Wine is renowned for its rich content of polyphenols, including resveratrol (Res), known for their health promoting properties. Steamed clam with wine, a popular Mediterranean delicacy that highlights the role of wine as a key ingredient. However, despite these benefits, resveratrol’s low bioavailability poses challenges. Could the process of steaming together with clam alter the digestive fate of resveratrol from wine? This study explores the potential of proteoglycan-based nanoparticles from freshwater clam (CFNPs) as a delivery vehicle for enhancing the stability and bioavailability of resveratrol, compared with wine and free Res’ solution, aiming to elucidate mechanisms facilitating Res’ absorption. The results demonstrated that CFNPs can effectively encapsulate Res with an efficiency over 70%, leading to a uniform particle size of 70.5±0.1 nm (PDI < 0.2). Resveratrol loaded in CFNPs (CFNPs-Res) exhibited an improved antioxidant stability under various conditions, retaining over 90% of antioxidant capacity after three-day storage at room temperature. The controlled-release profile of Res loaded in CFNPs fits both first and Higuchi order kinetics and was more desirable than that of wine and the free Res. Examined by the simulated gastrointestinal digestion, CFNPs-Res showed a significantly higher bioaccessibility and antioxidant retention compared to free Res and the wines. The discovery and use of food derived nanoparticles to carry micronutrients and antioxidants could lead to a shift in functional food design and nutritional advice, advocating much more attention on these entities over solely conventional molecules.

Abstract Background Public health professionals and students face increasing mental health challenges. Sudarshan Kriya Yoga (SKY), known for its mental health benefits such as stress reduction and improved emotional regulation, offers a promising strategy for enhancing well-being in public health education. Objectives To evaluate the immediate effects of a three-day participatory SKY workshop on mental well-being of Master of Public Health students at University College Dublin, Ireland. Methods A non-randomized, controlled pilot study will involve MPH students at UCD. Participants, aged 18 and above, enrolled in the MPH programme, will provide informed consent to attend a three-day SKY workshop in September 2024. The workshop, delivered by certified trainers, includes three sessions of three hours each. Standardised and validated Patient-Reported Outcome Measures (PROMs) such as the Perceived Stress Scale (PSS-10) and WHO-Five Well-being Index (WHO-5) will be used to assess perceived stress and mental wellbeing at baseline and immediately after the workshop. Results Based on previous literature, it is hypothesized that participants will show a significant reduction in perceived stress and improvement in mental wellbeing scores. Data will be analysed using descriptive statistics and Wilcoxon signed-rank tests to evaluate changes in PROM scores. Conclusions This pilot study aims to provide preliminary evidence on the effectiveness of SKY in improving mental wellbeing among public health students. Successful outcomes could support integrating SKY into the public health curriculum, promoting its adoption across other institutions, and enhancing the professional skills development of future public health professionals. This component is proposed in the ASPHER core curriculum programme for public health as an important cross curricular subject area Key messages • Integrating SKY Campus workshops into public health education enhances interprofessional skills and mental well-being, offering a holistic approach to professional development in global health. • This study uses standard PROMs to assess the SKY workshop’s impact, aiming for significant improvements in stress and mental well-being to shape global public health curricula.

Baguette is a globally acclaimed bakery staple, composed by a crispy crust and soft crumb, both containing Maillard reaction products (MRPs) with potential bioactivities. However, MRPs’ impacts on the nutritional and health attributes of baguette, particularly in terms of cellular and biological functions, are yet to be clearly elucidated. This study chemically characterizes the crust and crumb of baguettes and investigates the influence of the Maillard reaction on baguette’s nutritional profile, especially in the antioxidant and anti-inflammatory effects. The findings indicate an increase in browning intensity and advanced glycation end products (AGEs) from the baguette’s interior to its exterior, alongside a significant rise in the antioxidant capacity of the crust, suggesting the Maillard reaction’s role in boosting antioxidative properties. Both the crust and crumb demonstrated strong cytocompatibility with immune cells, capable of reducing cellular oxidative stress and regulating intracellular free radical levels. The crust effectively countered peroxyl radical-induced cell membrane hyperpolarization by 91% and completely neutralized the suppression of oxygen respiration in mitochondria, displaying higher efficacy than the crumb. In contrast, crumb extracts were more potent in inhibiting lipopolysaccharide-induced expression of proinflammatory cytokines, such as interleukins-1β (IL-1β) and IL-6, in macrophages. It could provide the fundamental data and cell-based approach for investigating the biological impacts of bread on immune responses, contributing to the refinement and supplementation of nutritional recommendations.

Abstract Background The long-term residential care (LTRC) sector in Ireland relies heavily on Health Care Assistants and Carers (HCAs). This workforce has become increasingly diverse in recent years, often relying on non-national temporary workers with varying levels of education. In 2022, of 22,495 HCAs and 5,289 Healthcare Support Assistants working in 563 nursing homes caring for some 30,000 residents, 22% were non-national. Their plight became evident during COVID-19 which had profound consequences in the LTRC sector. Objectives In this study, we investigate the recruitment, training, employment terms and conditions of HCAs in Ireland, as well as their general well-being and career satisfaction. Methods A cross-sectional study of members of ‘Care Assistance Ireland’, for which ethics approval was granted for an estimated sample of 1,052, is conducted. Validated instruments used are: the Maastricht Instrument for Sustainable Employability (MAISE); Utrecht Work Engagement Scale (UWES); General Wellbeing Schedule (GWBS) and Minnesota Career Satisfaction Survey (MCSS). Results The internal consistency reliability (Cronbach’s alpha) of GWBS and MCSS instruments were high. The response rate in the selected sample is estimated circa 60%, the majority being female and qualified. General well-being status will be investigated once all responses are submitted. Spearman correlation is predicated to show moderate to strong positive correlations (0.2-0.9) for all GWBS and MCSS questionnaires questions. While MAISE and UWES are still under investigation. It is predicted that there is variability in the requirements for, and terms and conditions of, employment among HCAs in Ireland, while job security remains a concern. Conclusions These findings reinforce the importance of ensuring standards for recruitment, training, job security and well-being for the LRTC workforce. The lack of educational requirements for HCAs in some settings is a critical consideration. Key messages • Findings will impel a more agreeable, consistent entry award in the healthcare system. • It profiles career needs of HCAs outlining the long-term shortfalls preventable with health policy enactments.

Ultra-processed foods dominate modern diets, often containing numerous additives to enhance flavor, texture, and shelf life. Concerns about the potential health risks of daily or excessive consumption have sparked online discussions. This study analyzed perceptions of food additives on Zhihu, a popular Chinese social platform. The findings revealed no significant difference in attitudes between experts and non-experts (p > 0.05), with experts relying on statistical data and non-experts drawing from personal experiences. An independent t-test indicated no significance in comment engagement (p > 0.05) among them. However, a chi-square test showed that experts were significantly more interactive, frequently replying directly to original posts and commenters (p < 0.05). This suggests that experts actively facilitate discussions, moving away from reliance on influencers and instead prioritizing high-quality, accessible scientific communication. The findings highlight the crucial role of interactive online platforms in bridging the gap between science and the public.

Background Contact tracing is a key component in controlling the spread of COVID-19, however little research has focused on learning from the experiences of contact tracing staff. Harnessing learning from those in this role can provide valuable insights into the process of contact tracing and how best to support staff in this crucial role. Methods Thematic analysis was used to analyse 47 semi-structured interviews conducted with contact tracing staff via telephone or Zoom at three time points in 2021: March, May and September-October. Results Six themes related to the contact tracing role were identified, including training, workforce culture, systems issues, motivation and support. While initially nervous in the role, participants were motivated to contribute to the pandemic response and believed the role provided them with valuable transferable skills. Participants described the training as having improved over time while desiring more proactive training. Sources of frustration included a perceived lack of opportunity for feedback and involvement in process changes, feelings of low autonomy, and a perception of high staff turnover. Participants expressed a need for improved communication of formal emotional supports. Increased managerial support and provision of opportunities for career advancement may contribute to increased motivation among staff. Conclusions These findings identify the experiences of contact tracing staff working during the COVID-19 pandemic, and have important implications for the improvement of the contact tracing system. Recommendations based on learning from participants offer suggestions as to how best to support the needs of contact tracing staff during a pandemic response.

Baguette, a globally acclaimed bakery staple, undergoes a complex Maillard reaction during the baking process, imparting a dual composition of crispy crust and soft crumb. Maillard reaction contributes to the unique flavor and texture of baguettes. However, its specific impact on the nutritional and health attributes, particularly in terms of cellular and biological functions, are yet to be clearly elucidated. This study investigates the chemical profiles of Maillard reaction products (MRPs) in baguette crust and crumb, and spatial distribution variations in the antioxidant activity. The impacts of baguette crust and crumb on cellular reactive oxygen species, mitochondrial activity, and inflammatory factors in RAW264.7 macrophages are also determined, aiming to elucidate the influence of the Maillard reaction on baguette nutritional efficacy. From the inside out, both the browning intensity and advanced glycation end products (AGEs) gradually increased, accompanied by a significant elevation in the antioxidant capacity of the crust (tested using ORAC/ABTS/FRAP). This suggests that the Maillard reaction enhances antioxidative properties. Additionally, both the crust and crumb exhibited a strong cytocompatibility for immune cells with capable of reversing cellular oxidative stress, regulating intracellular free radical levels. The crust mitigated the peroxyl radical induced cell membrane hyperpolarization by 91% and the suppression on the oxygen respiration in mitochondria by up to 100%, showing higher activities than the crumb. Conversely, the crumb more effectively inhibited the lipopolysaccharide (LPS)-induced proinflammatory cytokines expression of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in macrophages. It could provide the fundamental data and cell-based approach for investigating the biological impacts of bread on mucosal immune responses, contributing to the refinement and supplementation of nutritional recommendations.

Multilocus variable number tandem repeat analysis (MLVA) is a molecular subtyping technique that remains useful for those without the resources to access whole genome sequencing for the tracking and tracing of bacterial contaminants. Unlike techniques such as multilocus sequence typing (MLST) and pulsed-field gel electrophoresis, MLVA did not emerge as a standardized subtyping method for Listeria monocytogenes, and as a result, there is no reference database of virulent or food-associated MLVA subtypes as there is for MLST-based clonal complexes (CCs). Having previously shown the close congruence of a 5-loci MLVA scheme with MLST, a predictive model was created using the XGBoost machine learning (ML) technique, which enabled the prediction of CCs from MLVA patterns with ∼85% (±4%) accuracy. As well as validating the model on existing data, a straightforward update protocol was simulated for if and when previously unseen subtypes might arise. This article illustrates how ML techniques can be applied with elementary coding skills to add value to previous-generation molecular subtyping data in-built food processing environments.

Abstract Background This study describes the investigation and management of multiple outbreaks of SARS-Cov2 during the second and third wave of the pandemic at University College Dublin, Ireland from September 2020 to September 2021. Methods Relevant data were gathered as part of the public health outbreak investigations led by the UCD Internal Covid Control Team (ICCT) in collaboration with the public health teams of the Health Service Executive (HSE). Results are presented for PCR (polymerase chain reaction) confirmed cases and their close contacts, reported to the UCD ICCT between September 2020 to September 2021. Results There were 214 cases notified to ICCT. Among these, 153 cases were in residence on-campus cases. 73 epidemiologically linked clusters identified, where the number of cases linked with each cluster varied between 1 to 27. Additional cases during this period had no obvious epidemiological link to the identified clusters. Of 902 close contacts with PCR test results, 31.5% (n = 284) tested positive. 77% (n = 219) self-reported with mild to moderately symptoms while 23% (n = 65) self-reported as asymptomatic. Retrospective Whole Genome Sequence (WGS) analysis was undertaken after the outbreaks had subsided. The test positive cases were grouped into 6 clusters, and it was shown that many of the apparent sporadic cases were included in these clusters. Conclusions The proportion of close contacts testing positive varied significantly throughout the pandemic, with testing policy and type of exposure having the greatest impact. Whole genome sequencing can give a better understanding of webs of transmission to complement epidemiological investigations. It is now possible to undertake sequencing in real time where it can make a contribution to outbreak control and resolution. Public Health professionals should become familiar with WGS and bioinformatics as useful tools in their armory for the control of all communicable diseases not only SARS-CoV-2. Key messages • Combined epidemiological investigations and Whole Genome Sequencing (WGS) provide crucial insights into campus COVID-19 outbreaks, guiding effective control measures. • WGS integration enhances understanding of transmission patterns, identifies clusters, and equips public health professionals with data-driven approaches for outbreak management beyond SARS-CoV-2.

Listeria monocytogenes is a serious human pathogen and an enduring challenge to control for the ready-to-eat food processing industry. Cost-effective tools that can be deployed by commercial or in-house laboratories to rapidly investigate and resolve contamination events in the built food processing environment are of value to the food industry. Multilocus variable number tandem-repeat analysis (MLVA) is a molecular subtyping method, which along with other same-generation methods such as pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) is being superseded in disease tracking and outbreak investigations by whole-genome sequencing (WGS). In this paper, it is demonstrated that MLVA can continue to play a valuable role as a valid, fast, simple, and cost-effective method to identify and track Listeria monocytogenes subtypes in factory environments, with the method being highly congruent with MLST. Although MLVA does not have the discriminatory power of WGS to identify truly persistent clones, with careful interpretation of results alongside isolate metadata, it remains a powerful tool in situations and locations where WGS may not be readily available to food business operators.

This study explores the utilization of freshwater clam soup derived food nanoparticles (CFNPs) to encapsulate the antioxidant resveratrol (Res) which is found in red wine. We characterized the encapsulation properties and activities of the bound antioxidant. The results demonstrated that CFNPs can effectively encapsulate Res with a loading capacity exceeding 2.5%, and both encapsulation efficiency and bioaccessibility of over 70%, leading to a uniform particle size of 70.5 ± 0.07 nm and relatively low PDI (less than 0.2). CFNPs-Res exhibited an improved antioxidant stability under various conditions, with over 90% of antioxidant capacity retained after three-day storage at room temperature. The controlled-release profile of Res loaded in CFNPs-Res fits both first and Higuchi order kinetics and is more desirable than that of wine on its own and free Res solution. Examined by the simulated gastrointestinal digestion, CFNPs-Res showed a significantly higher antioxidant retention compared to free Res and wine on its own. We suggest that given there are nanoparticles in calm soup they may be in other foodstuffs with similar properties, and they too could be used to enhance the absorption of micronutrients and antioxidants. The use of nanoparticles to carry micronutrients and antioxidants could lead to a change in nutritional advice to increase the concentration of nanoparticle containing foods in the diet, carrying more bioaccessible micronutrients and antioxidants, in an attempt to make diets healthier and to tackle diet related disease.