This study aims to evaluate the impact of virtual simulation experiment teaching model and Massive Open Online Course (MOOC) teaching model on the teaching effect in debridement teaching. The study adopted a quasi-experimental design and used virtual simulation technology to construct a virtual simulation experimental teaching platform for debridement. This study was conducted at the Second Clinical College of Wuhan University. The experimental group was composed of 135 third-year clinical medicine students in the 2020 grade, who received the virtual simulation experimental teaching model; the control group was 122 third-year students in the same major in the 2019 grade, who used the MOOC teaching model. The performance of the two groups of students was evaluated through theoretical tests and animal experiment operation. In addition, the effectiveness of the experimental teaching model and student satisfaction were evaluated through questionnaire surveys. The theoretical test scores and animal experiment report scores of the experimental group were significantly higher than those of the control group, and the debridement animal experiment operation time of the experimental group was shorter than that of the control group, and the difference was statistically significant (P < 0.05). The post-class questionnaire survey of the experimental group showed that most students were satisfied with the virtual simulation experimental teaching model and believed that it represented the future teaching trend. In the teaching of debridement, virtual simulation experiment is an effective t teaching model, which not only helps to improve student performance, but also significantly reduces skill operation time and is recognized by students.

Inspired by the crucial role of matrix vesicles (MVs), a series of biomimetic vesicles (BVs) fabricated by calcium glycerophosphate (CaGP) modified polyurethane were designed to mediate the mineralization through in situ enzyme activation for bone therapy. In this study, alkaline phosphatase (ALP) was harbored in the porous BVs by adsorption (Ad-BVs) or entrapment (En-BVs). High encapsulation of ALP on En-BVs was effectively self-activating by calcium ions of CaGP-modified PU that specifically hydrolyzed the organophosphorus (CaGP) to inorganic phosphate, thus promoting the formation of the highly oriented bone-like apatite in vitro. Enzyme-catalyzed kinetics confirms the regulation of apatite crystallization by the synergistic action of self-activated ALP and the confined microcompartments of BVs. This leads to a supersaturated microenvironment, with the En-BVs group exhibiting inorganic phosphate (Pi) levels 4.19 times higher and Ca2+ levels 3.67 times higher than those of simulated body fluid (SBF). Of note, the En-BVs group exhibited excellent osteo-inducing differentiation of BMSCs in vitro and the highest maturity with reduced bone loss in rat femoral defect in vivo. This innovative strategy of biomimetic vesicles is expected to provide valuable insights into the enzyme-activated field of bone therapy.

Purpose:Polyhexanide is a safe and effective wound care antiseptic commonly used in clinics as wound rinsing solution and gel. However, the efficacy of Polyhexanide in treatment of wound infected with MRSA (methicillin-resistant Staphylococcus aureus) is unknown. The aim of this study is to assess the effectiveness of polyhexanide with povidone iodine in treating wound infected with MRSA. Patients and Methods:A prospective analysis of 62 patients with wound infections, who were admitted to our department from 2016 to 2020, was conducted in order to assess the efficacy of different treatment approaches. The patients were divided into two groups: the experimental group and the control group. In the experimental group, 30 patients underwent treatment with a combination of diluted povidone iodine and polyhexanide immersion. Conversely, in the control group, 32 patients received treatment with diluted povidone iodine along with systemic antibiotic therapy. The time required for dressing changes, bacterial clearance rates, and the Bates-Jasen wound assessment tool (BWAT) scores were utilized as indicators to evaluate the effectiveness of the treatments. Results:In our study, the findings indicated that the experimental group exhibited a lesser number of days for the bacteria culture to turn negative compared to the control group, with statistical significance (p<0.05). Furthermore, the decline in the BWAT score was significantly greater in the experimental group than in the control group (p<0.05). However, no significant differences were observed in terms of dressing times and wound coverage between the two groups (p>0.05). Conclusion:Polyhexanide combined with povidone iodine can effectively remove MRSA infection in wounds and reduce antibiotic dosages.

Peritendinous adhesion is a common complication following tendon injury repair, posing a significant clinical challenge that requires urgent attention. The primary cause of peritendinous adhesion is the excessive deposition of collagen matrix due to the abnormal proliferation of fibroblasts in an inflammatory state. Janus kinase2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are key signaling molecules involved in cell proliferation and fibrosis development in various organs. However, the role of the JAK-2 and STAT3 signaling pathways in peritendinous adhesion fibrosis remains unclear. In our study, we first observed upregulation of p-JAK2 and p-STAT3 proteins in human peritendinous adhesion specimens and rat peritendinous adhesion models. In vitro, the JAK2/STAT3 pathway inhibitor AG490 effectively inhibited TGF-β1-induced fibroblast proliferation. Wound healing and transwell assays demonstrated that AG490 suppressed TGF-β1-induced fibroblast migration. Furthermore, we found that AG490 decreased the expression of pro-inflammatory factors, including IL-1β and TNF-α, as well as extracellular matrix (ECM) proteins in fibroblasts under TGF-β1 stimulation. In vivo, histological staining showed that AG490 prevented fibrous tissue formation in a rat model of tendon injury. Moreover, AG490 inhibited the overexpression of pro-inflammatory factors IL-1β and TNF-α, as well as ECM in the peritendinous adhesions. In conclusion, AG490 inhibited fibrosis and inflammation in injured tendons by targeting the JAK2-STAT3 signaling pathway, presenting a promising strategy for the prophylaxis of peritendinous adhesions.

[This corrects the article DOI: 10.1155/2021/6612840.].

Identifying the ideal implantation site is important for the long-term stability and effectiveness of follow-up restorations. Implant surgical guide and navigation are used to determine the implantation site in clinic and improve the precision of implantation. However, due to difficulties in digital methods, such as multiple procedures, high cost, and actual accuracy of more than 1 mm, many physicians still prefer to operate with free hand. In preoperative, intraoperative, and postoperative procedures, time-saving and practical methods for implant site evaluation are lacking. In many cases, oral physicians found that the position deviates only by cone beam CT, which was costly to modify the position. In this article, we presented a precise implantation insertion technology that is guided by a measurable technique throughout the implantation application for all implant systems. This method was guided by a dynamic control measuring ruler, which functions together with the measuring and intraoperative locating rulers. The 3D space of the operative area was measured by a measuring ruler prior to operation, and the implant plan and quantitative guidance design were conducted according to the measured and cone beam CT data. The whole implantation process was guided by the dynamic control measuring ruler, and measuring verification results were also considered. This method can realize the quantification of the entire preoperative space analysis, intraoperative precise implantation guidance, and postoperative site measurement and evaluation. This practical technique also helps to adjust the position, improve the implantation accuracy and is suitable in generalizing dental implantation.

海德格尔所谓"哲学是一种出类拔萃的生存论现象",说的不是一种企图凌驾于诸学科之上的哲学—自恋,而是经过Philo-sophia与Meta-physica之间的思想震荡,涌临而来的一个思想的实事:作为对智慧之热爱的哲学(Philo-sophia),始终不让自身止步于任何可能的现成状态,始终只能不断从Meta-physica中那个physica的位置奋起,不断翻新其存在.因为只有当它通过"问出一切存在者之外去"的"回行",亦即只有当它行Meta之际,方才有"爱—智"(Philo-sophia)这回事情发生.因此,作为对智慧之热爱,哲学必须在彻底的追问中突入超越之地带,就是说,必须生存论地"出类拔萃".

海德格尔 《无蔽》 一文,以荷马史诗中奥德修斯之"(ε)λ(á)νθανε"为例,阐释了一个"希腊经验".这一经验越出了"谁隐瞒谁、 谁注意谁"的认识论格局,启示出"保有遮蔽-保有无蔽"的整体运作;在我们的日常在世中,广泛地亲历着这种无蔽-遮蔽的"自在"运作,这种在每一无蔽存在者中持续涌动着的"浩瀚之境".

一种宗教信仰之实事,必定意味着信仰及其被信仰者纯然一体地“存在”,亦即纯然一体地给出自身.作为典型的意向性生存方式,信仰就是“去-信仰”,就是时时处处地去“重新信仰”,重新活在信仰的“充实”之中,否则那伸出的双手,那凝望的双眼,便永远都是“空空的”.

In his late seminars, Heidegger began to pay more attention to Karl Marx than before. Firstly, in 1966, he viewed Marx as a model of Hegel’s dialectical philosophy. then, in 1968, he partly agreed that there was difference between Marx’s and Hegel’s concept of product. In 1969, by an analysis on the relation of practice and theory, Heidegger once again viewed Marx as a Hegelian. Finally, in 1973, Heidegger regarded his interpretation of Marx as a non-political one, meanwhile he viewed Marx as a metaphysician and a nihilist who forgot Being. Although there is something new in Heidegger’s understanding on Marx, more misinterpretations are left also.

>司马迁在《史记》之《秦始皇本记》及其卷二十八《封禅书》中记述了秦皇汉武的神仙狂热。在《封禅书》的末尾,司马迁写道:"而方士之候神人,入海求蓬莱,终无有验。而公孙卿之候神者,犹以大人之迹为解,无有效。天子益怠厌方士之怪迂语矣。然羁縻不绝,冀遇其真。自此之后,方士言神祠者弥众,然其效可睹矣。"这是一段很值得体味的话,至少有两点引人深思:第一,司马迁接连用了三个"效验",即"终无有验"、"无有效"、"其效可睹矣"。很明显,无论是司马迁还是被司马迁所记述的秦皇汉武,其"神仙"均是在"效验"视界中的神仙。就是说,

Following the famous phenomenological slogan "To the things themselves",we are sent directly into the fundamental intention of modern western philosophy.Through the foundation of Cartesianism,philosophy has constructed the intrinsic "home" and the dependable "land": pursuing absolute certainty in the light of self-consciousness.From Descartes to Hegel,philosophy had perched on this "home" and had planted,cultivated and harvested on this "land".Hence,a breakthrough from self-consciousness is imperative.After the sweeping of Husserl's phenomenology as "rigorous science",did "the things themselves" finally walk out from the ambush on all sides of self-consciousness? It is under the oppression of this predicament that Heidegger's thinking has stood out.By the phenomenological thinking of "being-in-the-world",Heidegger dissolves consciousness philosophy's immortal body,and then hits epistemological philosophy's "being-in-itself" which has been peaceful,pervading but unreachable,i.e."the things themselves" which are rolling in,agitating and sweeping us over.

The Xiang'er Annotation to Laozi was of epochal significance in the rise of Taoist religion,because the ideas of this annotation served as the road signs of the Taoist religion;for example,they were the religious doctrines in Wu-Dou-Mi Taoist sect.The religious nature expounded in this classic annotation manifests itself in the Way of Xiang'er,which transformed the traditional belief in immortals from a soft individual faith into a powerful communal religious belief.

The system uses SQL tool to build the database core,Dreamwaver tool to design the interactive page.Users,based on different status authentication,hand on or approve the scientific research project.The final results of the system will be returned to both terminals,while data will be stored.The system uses the Internet to approve the declaration from time to time,so a lot of human time will be saved with higher efficiency.

《我思念的长眠中的南国公主》是旅台马来西亚华人作家张贵兴近年来的争议性作品。该小说延续了其一贯的风格,以典型的张贵兴式"情欲美学"对婆罗洲雨林中的"群象"进行暴力式书写,赤裸裸地呈现了两性间的仇恨与人性的罪恶。同时,在结构方面,南洋和台湾两条叙事线索虚实相生,展示出了独属于马华作家的伤痛,及其在迷幻、奢靡的文字游戏中找寻与守候的无奈宿命。

foundation of The Instructing, in any sense,has always been laid by originalfaith in the Sacred Way. former at any time derived from latter.In other words,just because depending on Dasein of faith as well as relying on existence of faith, it is possible for sages to share holiness of The Instructing according to Sacred in brilliance of their possessed faith and thus truly realize The Instructing according to Sacred Way and all under heaven yield submission to them. The Instructing according to Sacred is most original and secret existing way of Chinese ancient civilization.These characters embody foundation of kingly way's legality,contain origin of sages' holiness and hide secret of whole ideology's long-stretching operation.

“Immortality Idea” and “Immortality Faith” are quite different dimensions in the human existence. Immortality, as a kind of faith, is not any concepts, thoughts or knowledge concerning immortality but a special existential way released from human being as potentiality for being. The author holds that immortality in essence is a kind of regenerative way impending in revealing, namely, the regenerative way in which mortals exist towards infinite horizon.

海德格尔对桥的现象学沉思的启示在于:让"物"抖落自己的刚性外壳,从而让自身释放到天、地、人、神四相的柔性存在中去;让人之栖居从"遗忘存在"的对存在者的偏执追逐中解放出来,从而让人之栖居那深渊般的自由是其所是地绽露出来,开放出来.

海德格尔说:长久以来统治我们的对物的形而上学的规定不过是对物的扰乱,它并没有赢获物之物性.海德格尔宣称"物的本质乃是聚集",这一思想突破了几千年根深蒂固、枝繁叶茂的传统的物观念,粉碎了以对象化为本质的循环之路的概念性思维对事情本身的拦截.不管主观、客观,不管具体、抽象,物不再作为对象之物、现成之物现身,物只是开显着又隐匿着的"聚集"本身.在我们反复咀嚼着"物乃聚集本身"之际,一个开端,一个作为真正转折的"思"的开端,已经引而不发地到时了.