In Ayurveda, the commonly used term is Pariksha. Pariksha means viewing or examining an object from all sides and aspects. There are different synonyms for Pariksha like Pramana, Jnana, Upalabdhi. Before prescribing medicine or treatment for an individual, the examination is the basic primary tool used to define both Rogabala and Rogibala. The purpose of Pariksha is to obtain knowledge regarding the line of treatment that should be adopted to correct the morbidity. Hence, a patient should be examined with the help of Prakruti, Vikruti, Sara, Samhanana, Pramana, Satmya, Satwa, Aharashakti, Vyayamashakti and Vaya. These ten factors are considered Dashavidha Pariksha, which helps determine the Rogabala and Rogibala of the individual. Pariksha should be done systemically to get the outcome effectively. It is essential to know the individual's condition to carry out proper treatment modalities.

Hashimoto's thyroiditis is chronic inflammation of the thyroid gland due to the formation of autoantibodies. It is an autoimmune disorder that would lead to hypothyroidism. Failures of host defense do occur, however, and fall into three broad categories: immune deficiencies, autoimmunity and hypersensitivities. Ayurveda has a unique approach in treating the auto immune disorders through Shodhana and Rasayana Therapies. Due to Nidana Sevana, Kapha - pitta vata dushti takes place leading to Jatharagni Vaishamya and Ama Utpatti. This causes Asamyak Ahara Pachana, Rasavaha Srotodushti, Rasa Dhatwagni Vaishamya leads to Uttarottara dhatwagni and Dhatu Vaishamya. When Agni becomes too low, metabolism is affected. Shodhana karma has a great efficacy in Sroto-shodhana and in turn it corrects the functioning of Jatharagni, dhatwagni Srotas and Doshas. The present case study includes a female patient of 26 years age suffering from Hashimoto's thyroiditis complaints of gradual increase in size of swelling over neck for 3 years She was treated with Shodhana and Shamana Aushadhis for 3 months and found effective in reducing the levels of antibodies.

IN BRIEFDiabetic peripheral neuropathy affects up to 50% of older type 2 diabetic patients. Whereas some patients may have extremely painful symptoms, others with a more marked neuropathic deficit may be asymptomatic. Diagnosis requires careful examination of the lower limbs. Management involves establishing that the neuropathy is caused by diabetes instead of more sinister causes and aiming for optimal glycemic control. Medications, usually tricyclic drugs or anticonvulsant agents, may be required. Patients with peripheral neuropathy must be considered at risk of insensate foot ulceration and must receive preventive education and podiatric care.

Ankylosing spondylitis is an auto immune, systemic rheumatic disease, meaning it affects the entire body.A type of arthritis in which there is long term inflammation of the joints of the spine.Typically, the joints where the spine joins the pelvis are affected.Occasionally other joints such as the shoulders or hips are involved.Modern science has very limited option to treat Ankylosing spondylitis.So there is a growing interest towards Ayurvedic system of medicine for the treatment of Ankylosing spondylitis.Panchakarma procedures like Virechana, Basti, Nasya, etc play a significant role in the management of Ankylosing spondylitis.Hence this article highlights the importance of Panchakarma in the management of Ankylosing spondylitis.

The color of the skin plays very important role in the society especially in India.Switra is a hypopigmentary disorder of skin.Based on the symptoms, Switra can be correlated to Vitiligo of modern science.This Vitiligo affects the estimated 1% of world's population.In the present study 22 cases of Switra were sampled in to 2 groups with 11 patients in each group.The first group of patients received Sramsana therapy followed by internal medicine and lepa.Patients of second group received only lepa.In first group moderate improvement was seen in 72.73 % patients and mild improvement seen in 22.27 % patients.In test group marked improvement was seen in 18.18 % patients whereas marked improvement was observed in 63.64 % patients and mild improvement in 18.18 % patients.When the results of the two groups were compared with unpaired't' test statistically non-significant was obtained which proves the application of lepa alone can produce repigmentation in the mandalas by decreasing their number and size.

Among Nasagath Rogas, most of the acharyas described pratishyaya with its complications which proves the seriousness of the disease.Acharya susrutha clearly mentioned in Uttar tantra that Pratishyaya is the disease condition in which Vata and Kapha dusti was observed.Allergic Rhinitis is a disease characterized by sudden and frequent attacks of sneezing, profuse watery nasal discharge associated with nasal obstruction which is intermittent, watering of the eyes, heaviness of head, respiratory distress and anosmia.The present study aims to comparatively evaluate the clinical efficacy of shadbindu gritha nasya with haridra khanda internally in pratishayaya.The principle objective of the study is to find a most effective, economical and simple treatment for pratishayaya.Here 45 patients of pratishyaya-Allergic Rhinitis were treated in 3 groups.15 patient of group A treated with Shadbindu gritha Nasya.15 patient of group B treated with Haridrakhanda orally.15 patient of group C treated with both Shadbindu gritha nasya and haridrakhanda as a combined therapy.After the enrollment of the patients in the study, vital signs and symptoms of Pratishyaya-Allergic rhinitis such as Nasa srava, Khavatu, Nasa avarodha, gala talu shuskata, were studied before and after the treatment.The results of the study indicated that the group c bestowed with highly significant relief in almost all the signs and symptoms in comparison to group A and group B.

Abhraka is one of the most important Rasadravya mentioned in Rasashastra and most widely used in Lohavada, Dehavada and Chikitsa.According to Minerology Abhraka (Mica) comes under Sheet Silicate group.Mica is a complex mineral, tough and hard.Hence Nirvapa is adopted to make it brittle so that it is easy to convert in to powder form.For the Nirvapa Kanji, Gomutra, Thriphala Kwatha and Goksheera were mentioned.In this Study, Goksheera and Badara Kwatha were selected for Abhraka Shodhana as Dhanyabhraka process was not mentioned for Badara Kwatha Shodhita Abhraka.Badara Kwatha Shodhita Abhraka doesn't need Dhanyabhraka process as it becomes small particles as Dhanyabhraka.