The immune system plays a crucial role in protecting the body against infections, and its suppression can lead to severe complications during chemotherapy. Bee products are rich in bioactive phenolic compounds with antioxidant and immunomodulatory properties. This study aimed to characterize the phenolic composition of Moroccan honey, bee pollen, and propolis and to evaluate their potential, individually and in combination, to counteract CTX-induced immunosuppression in mice. Phenolic compounds were analyzed by HPLC-DAD, total phenolics, and flavonoids were quantified using colorimetric assays, and antioxidant activity was determined by DPPH, RP, and TAC methods. In vivo, CTX-induced immunocompromised mice were distributed into six groups and treated orally for 21 days with honey (1 g/kg), bee pollen (100 mg/kg), propolis (100 mg/kg), or their mixture at a volume ratio of 1:1:1 (v/v/v). Results showed that propolis had the highest total phenolic and flavonoid content and exhibited the strongest antioxidant activity. All bee products significantly improved leukocyte counts, thymus and spleen indices, IgG/IgM levels, and delayed hypersensitivity response compared with the CTX non-treated group, with propolis, bee pollen, and the mixture showing the most pronounced effects. Molecular docking revealed strong interactions of major phenolics (apigenin, kaempferol, isorhamnetin, pinocembrin) with immune-related proteins (STAT3, JNK, and SYK), suggesting a multi-target mechanism of immunoprotection. These findings highlight Moroccan bee products as promising natural adjuvants for supporting immune function during chemotherapy.

Diabetes mellitus is a major global health challenge associated with high morbidity and mortality. Natural products, including bee-derived products, are valued for their bioactive compounds with potential antidiabetic properties. The present study aimed to experimentally evaluate and compare the antihyperglycemic and protective effects of honey, propolis, bee pollen, and their combination on acute and chronic hyperglycemia. Acute hyperglycemia was assessed using the oral glucose tolerance test (OGTT), while chronic hyperglycemia was evaluated using a streptozotocin (STZ)-induced experimental type 1 diabetic model. Diabetic animals were orally treated for three weeks with distilled water (10 mL/kg), glibenclamide (2.5 mg/kg), honey (1 g/kg), bee pollen (100 mg/kg), propolis (100 mg/kg), or their mixture (10 mL/kg, 1:1:1, v/v/v). Glycémia, body weight, biochemical (AST, ALT, urea, creatinine), inflammatory (IL-6, CRP), and histological parameters were evaluated. In addition, molecular docking was performed to explore potential interactions between major phenolic compounds and key metabolic (α-amylase, α-glucosidase) and inflammatory targets (DPP-IV and COX-2). In the OGTT, all bee products significantly reduced postprandial glucose excursions, with honey showing the most pronounced effect. In STZ-induced diabetic rats, bee products markedly reduced blood glucose levels, prevented body weight loss, improved hepatorenal biomarkers, decreased IL-6 and CRP levels, and preserved pancreatic histological features, with the mixture showing the most sustained overall improvement. Docking analyses revealed favorable predicted interactions between selected phenolic compounds and α-amylase, α-glucosidase, DPP-IV, and COX-2. These findings provide experimental support for the traditional use of bee-derived products in the management of hyperglycemia and diabetes-associated inflammatory and tissue alterations.

Honey from citrus limon is of interest for wound healing due to its antimicrobial, antioxidant, and immunomodulatory properties . This in vitro study investigates whether citrus lemon honey (CLH) can modulate key cellular and biochemical processes involved in wound healing, in comparison with Manuka honey. Antioxidant, anti-inflammatory, and antibacterial activities were evaluated alongside keratinocyte (HaCaT) proliferation and migration assays. Physicochemical analysis showed high water-soluble protein content (480.9 ± 28.4 mg equivalent [Eq] bovine serum albumin/100 g), acidic pH (3.4 ± 0.02), low moisture (19.5%), and moderate electrical conductivity (41.6 ± 2.61 μS/cm). In addition, CLH exhibited notable phenolic (313.6 ± 0.6 mg Eq gallic acid/100 g) and flavonoid contents (6.9 ± 2.6 mg Eq quercetin/100 g), accompanied by strong antioxidant activity (total antioxidant capacity: 3.5 ± 0.05 g Eq ascorbic acid/100 g). CLH demonstrated antibacterial activity against both Gram-positive and Gram-negative bacteria (minimum inhibitory concentrations of 0.8–3.1 w/w%), including clinically relevant wound-associated pathogens, highlighting its potential to reduce microbial burden and prevent infection in wound environments. Furthermore, CLH modulated nitric oxide production in lipopolysaccharide-activated THP-1 macrophages. Functionally, CLH promoted keratinocyte viability and migration in a concentration-dependent manner, with an approximately 20% increase in cell viability at 1–2 mg/mL and a 35% enhancement in migration, without cytotoxicity. These effects were comparable in trend, though less pronounced, to those observed with Manuka honey. Taken together, the combined antibacterial, anti-inflammatory, and pro-regenerative effects suggest that CLH may support wound healing by enhancing tissue repair and limiting infection. From a host–microbe interaction perspective, the antibacterial and immunomodulatory effects of CLH suggest a coordinated role in wound healing, where reduced microbial burden and controlled regulation of inflammation may act synergistically to support tissue repair and restore skin integrity. However, further in vivo and clinical studies are required to confirm its therapeutic relevance.

Background: Acute mesenteric ischemia (AMI) is a rare vascular and digestive emergency associated with high mortality. Its clinical presentation is often nonspecific, which contributes to delayed diagnosis and progression to intestinal necrosis. Methods: We conducted a retrospective, longitudinal, descriptive and analytical study in the polyvalent intensive care unit A4 of Hassan II University Hospital in Fez over a seven- year period, from January 2013 to December 2019. All adult patients hospitalized for AMI were included when the diagnosis was established preoperatively on clinical, biological and radiological grounds, or intraoperatively. Incomplete records and patients managed only in the resuscitation room were excluded. Statistical analysis was performed using SPSS 20. Quantitative variables were expressed as means and qualitative variables as percentages. Univariate analysis was performed, with statistical significance set at p<0.05. Results: Sixteen patients were included, representing approximately 0.3% of ICU admissions during the study period. The mean age was 64.8 ± 12.68 years and 62.5% of patients were women. Atrial fibrillation was the most frequent comorbidity (43.75%). The mean delay before consultation was four days. All patients presented with abdominal pain, 62.5% with vomiting and 31.25% with an occlusive syndrome. CT/CT angiography established the preoperative diagnosis in 10 patients. Fifteen patients underwent surgery; intestinal necrosis was found in all operated patients. Invasive mechanical ventilation was required in 81% of patients, vasoactive drugs in 62%, and therapeutic anticoagulation in all patients. Overall mortality was 62.5%. Factors significantly associated with mortality were central venous catheterization, invasive mechanical ventilation and septic shock. Conclusion: AMI in the ICU remains associated with high mortality. Prognosis depends on early clinical suspicion, rapid CT angiography and multidisciplinary management involving intensive care, digestive surgery and vascular surgery.

Carotid endarterectomy is a well-established procedure for the secondary prevention of stroke. While general anaesthesia (GA) has traditionally been the standard approach, ultrasound-guided locoregional anaesthesia (LRA) has gained popularity due to advantages such as improved haemodynamic stability and real-time neurological monitoring. In our series, ultrasound-guided cervical plexus block was systematically employed, providing satisfactory anaesthetic comfort without the need for conversion to GA. These findings are consistent with existing literature, including the GALA trial, which highlighted the importance of individualised anaesthetic choice. Ultrasound guidance enhances the safety and precision of cervical blocks by enabling direct visualisation of anatomical structures and optimising anaesthetic diffusion. In our experience, the block was performed in an average of 10 minutes, with high surgeon satisfaction. Complications were rare and minor .Postoperative analgesia was generally effective with minimal opioid use. Despite the study’s limitations, our results support ultrasound-guided LRA as a safe and effective alternative to GA in carotid endarterectomy.

Background: Difficult tracheal intubation (DTI) may be a major cause of morbidity and mortality if not anticipated. Pre-anesthesia airway risk assessment is a must for safety reasons. The aim of this study is to analyze the clinical predictive criteria for DTI with particular focus on the Mallampati score in the supine and sitting positions. Methods: This is a 6-month prospective observational study including all surgical adult patients requiring oro-tracheal intubation and not relevant to an indication for fibroscopic intubation nor urgent surgery (N = 500). DTI predictive criteria, composite scores, mask ventilation, laryngoscopy, and glottic catheterization were collected. Primary outcome was the ability of the collected criteria to predict DTI. Secondary outcome was the comparison of the Mallampatti score in the sitting vs. supine position to predict DTI using Cohen's kappa non-parametric test. Results: Mean age was 46.5 years. 10 % had diabetes. The incidence of DTI was 26 %. Six predictive factors for DTI were identified in multivariate analysis (p < 0.05): body mass index greater than 30 kg/m(2), mouth opening <3.5 cm, thyromental distance <6.5 cm, grades III and IV of Mallampati sitting and supine scores and Cormack and Lehane score IV. Mallampati supine score outperformed Mallampati sitting score in predicting the risk of difficult intubation, with respective ROCs at 0.898 (IC95 % 0.857-0.938) vs 0.751 (IC95 % 0.678-0.824). Conclusions: Incidence of DTI was higher in our population, probably related to our specific context of care. Predictive factors of DTI are consistent with previous studies while composite scores are not conclusive. The supine Mallampati performed better than sitting Mallampati in predicting DTI and may be reliable pre-operatively to assess the airway in patients unable to sit.

BACKGROUND:Propolis and honey are known for their antioxidant, hypoglycemic, and antiproteinuric effects. AIM:To explore the effect of propolis, and honey, against D-glucose-induced hyperglycemia, acute kidney injury (AKI), liver injury, dyslipidemia, and changes in the oxidants and antioxidants in renal, hepatic, and pancreatic tissues. METHODS:The chemical analysis and antioxidant content of propolis and honey and their effect on alpha-amylase and alpha-glucosidase activity were studied. The study included five groups of male rats; four groups (2, 3, 4 and 5) were treated with D-glucose, and one group was untreated, group 1. In addition to D-glucose, groups 3, 4, and 5 were treated with propolis, honey, and their combination, respectively. Blood glucose levels, liver and renal function tests, urine protein and electrolytes, oxidant and antioxidant parameters, and histopathological changes in hepatic, renal, and pancreatic tissues were examined. RESULTS:Propolis contains a higher level of total protein and exhibits a higher antioxidant activity. Honey has a higher alpha-amylase and glucosidase inhibitory activity than propolis. D-glucose caused a significant elevation of blood glucose, insulin, homeostasis model assessment, blood urea, creatinine, lipid parameters, liver enzymes, and urine protein levels. It significantly increases malondialdehyde and decreases antioxidant parameters in pancreatic, hepatic, and renal tissues. D-glucose caused histopathological changes in hepatic, renal, and pancreatic tissues; these changes were significantly ameliorated by honey and propolis. CONCLUSION:Propolis, honey, or their combination treated hyperglycemia, AKI, proteinuria, liver injury, and dyslipidemia induced by D-glucose, most likely, through their antioxidant activity and alpha-amylase and alpha-glucosidase inhibitory activity. This will pave the way for testing this natural combination in the prevention of diabetic complications, as a complement to basic therapies.

Methanol poisoning is an uncommon poisoning in France. Absorption for suicidal or accidental purposes (adulterated alcohols) can occur through the digestive or transcutaneous route. The product is toxic through its metabolites: formaldehyde and formic acid, responsible for an inhibition of the enzymes of the respiratory chain and a metabolic acidosis whose part is linked to formates and lactates remains to be specified. After a variable period, corresponding to the metabolism time of the product, the prodromes appear in the form of digestive and visual disorders. The period of state associates in severe forms a coma of variable appearance, sometimes convulsive, a state of cardiogenic and/or hypovolemic shock and optic neuritis: severe metabolic acidosis is accompanied by an increase in anionic indoses and the osmolar gap. Brain CT scan reveals non-specific hypodensities of the central gray nuclei that can guide the etiological diagnosis of a coma. Only the methanol dosage will provide diagnostic certainty. Treatment, a toxicological emergency, must be started before the results. It requires massive alkalinization associated with the usual treatments for shock and coma. Etiological treatment is based on the purification of toxic substances by hemodialysis rather than peritoneal dialysis, which is less effective, and on blocking the metabolism of methanol with methyl alcohol or 4-methylpyrazole.

This study provides a comprehensive evaluation of Ziziphus jujuba honey, commonly referred to as sidr honey (SH), collected from five distinct botanical origins in Morocco: SHE from Errachidia (Daraa-Tafilalet), SHZ from Zaggota (Rabat-Sale-Kenitra), SHA from Ain Chair (Oriental), SHS from Saka (Oriental), and SHK from Khenifra (Beni Mellal-Khenifra). The research investigates the honey’s antibacterial properties against a range of gram-positive and gram-negative bacterial strains. Furthermore, key physicochemical parameters were analyzed according to international honey standards, including pH, electrical conductivity, Brix scale, refractive index, color, hydrosoluble protein, and total sugar content. Besides, bioactive compounds of SH honey samples, namely Total Flavonoid Content (TFC), and Total Phenolic Content (TPC) were measured. The antioxidant capacity was assessed through Total Antioxidant Capacity (TAC) measurements and the DPPH assay. The results demonstrated significant variations in the biochemical and physical properties of the SH samples. SHZ had the highest protein content at 209.59 ± 0.91 mg Eq BSA/100 g and TFC of 77.10 ± 1.21 mg QE/100 g, besides a strong antioxidant activity with a DPPH IC50 value of 10.53 ± 0.01 mg/ml and a TAC value of 50.23 ± 0.60 AAE/100 g. Antibacterial assays revealed that SHZ displayed the most potent antibacterial effects, particularly targeting gram-negative bacteria, with an MIC of 0.024 w/w% for S. aureus and 0.049 w/w% for P. aeruginosa, both with corresponding MBC values. In contrast, SHS demonstrated weaker antibacterial activity, with MIC values reaching 12.5 w/w% for several strains. In addition, the analysis of the honey samples indicates substantial relationships among physicochemical parameters, bioactive components, antioxidant and antibacterial activities. These results demonstrate that SH exhibits notable antibacterial and antioxidant properties, underscoring its potential as a natural health product. However, further studies are essential to explore the precise mechanisms driving these bioactive effects and their broader implications for health and nutrition.

Background: Wernicke encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency. Though often linked to alcoholism, it can result from prolonged vomiting during pregnancy (hyperemesis gravidarum).Case Presentation: We describe the case of a 21-year-old primigravida at 16 weeks’ gestation, presenting with incoercible vomiting. Initial investigations revealed hepatic cytolysis and biliary sludge. Post-surgical deterioration led to neuropsychiatric symptoms. Brain MRI revealed periaqueductal hyperintensities suggestive of WE. High-dose intravenous thiamine resulted in marked clinical improvement.Conclusion: WE is a medical emergency that should be considered in pregnant women with persistent vomiting. Early recognition and treatment are crucial to prevent irreversible complications.

Bee pollen is a valuable cocktail of natural compounds with high dietary and health importance for both bees and humans. Recently, the consumption of this bee product has risen significantly because of the advanced consumer knowledge of its nutritional and health benefits. Hence, this chapter highlights the composition, physicochemical and functional properties, biological activities, health benefits, and food safety of bee pollen. The data summarized in this chapter reveal that bee pollen is rich in nutrients and bioactive compounds. In addition, it has been proven that this bee product has many health benefits, including anticancer, antioxidant, antimicrobial, and antidiabetic properties. In sum, bee pollen is unequivocally a nutraceutical product if it is well stored and free from contamination with pesticides, heavy metals, and microbes.

BACKGROUND:Cardiopulmonary resuscitation (CPR) training is crucial for nursing students as future nurses are the first responders in the ambulatory and hospital care chain. Simulation-based learning has been shown to be more effective in acquiring the knowledge and technical and non-technical skills required for CPR. The present study aims to evaluate the impact of high-fidelity simulation-based adult CPR training on the acquisition and retention of knowledge and the development of technical and non-technical skills of nursing students at the Higher Institute of Nursing Professions and Health Techniques in Fez, Morocco. METHODS:We conducted an interventional study with 49 nursing students. Twenty-five students (51.02%) in the simulation group received both traditional CPR training (theoretical lecture and demonstration of procedures) and simulation CPR training, while 24 students (48.97%) in the control group received only traditional training. Data were obtained using a questionnaire on theoretical knowledge of CPR, a technical skills assessment grid, and the Team Emergency Assessment Measure (TEAM) for non-technical skills. RESULTS:The post-test scores for theoretical knowledge immediately after simulation were significantly higher for the simulation group (16.41±1.73 out of 20) than for the control group (13.15±1.96 out of 20). Mean CPR knowledge retention scores 30 days after training were significantly higher in the simulation group (15.60±1.71) compared with the control group (11.38±1.93). Assessment of technical skills on a high-fidelity mannequin showed a considerable advantage for the simulation group (30.88±1.64 out of 34) over the control group (18.00±0.78 out of 34). In addition, the results demonstrated a significant difference between the TEAM score of the simulation group (37.84±2.67 out of 44) and the control group (22.33±0.96 out of 44) and a significant difference between the Global Team Performance of the simulation group (8.16±0.68) out of 10 and the control group (4.83±0.38). CONCLUSION:The findings demonstrated that adult CPR training using high-fidelity simulation was superior to the traditional method with regard to knowledge acquisition and retention and the development of technical and non-technical skills in undergraduate nursing students.

Introduction: Cardiac arrest is one of the most serious circumstances needing quick response. Nurses are the first to arrive at the patient's bedside in the event of cardiac arrest, starting cardiopulmonary resuscitation (CPR).As a method of teaching CPR, high-fidelity simulation has been demonstrated to have a substantial impact.Thus, the present study aims to evaluate the impact of adult CPR training based on high-fidelity simulation on anxiety and evolution in self-efficacy, satisfaction and self-confidence of undergraduate nursing students at the Higher Institute of Nursing Professions and Health Techniques in Fez, Morocco. Methods: An intervention study with a simulation group and a control group was carried out with 49 student nurses. The simulation group (n=25) received traditional training (theoretical lecture and procedural demonstration) and simulation-based CPR training, while the control group (n=24) received only traditional training. Data were obtained using the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2), the Self-Efficacy Scale and the Student Learning Satisfaction and Confidence Scale. Results: Post-test results of the STAI-Y1 scale revealed a significant reduction in situational anxiety in the simulation group, with a mean score of 30.84 +/- 1.84 out of 80, compared with the control group score (43.04 +/- 1.36). Assessment of post-simulation self-efficacy showed a significant advantage for the simulation group (35.28 +/- 2.47) out of 40 over the control group (20.96 +/- 1.36). Mean CPR self-efficacy retention scores 30 days after training were significantly higher for the simulation group (34.80 +/- 2.19) than for the control group (20.88 +/- 1.36). Nevertheless, a significant decrease in mean self-efficacy scores was recorded for the simulation group between the post-test immediately after simulation training (35.28 +/- 2.47) and the post-test 30 days after training (34.80 +/- 2.19). Thus, the results revealed that mean satisfaction (23.16 +/- 0.68 out of 25) and self-confidence (36.08 +/- 0.99 out of 40) scale scores were high immediately after the simulation experience in the simulation group. Nevertheless, a significant increase in satisfaction (24.08 +/- 0.99) and a significant decrease (33.72 +/- 1.59) in self-confidence were recorded 30 days after simulation training. Conclusion: The outcomes demonstrated that adult CPR training using high-fidelity simulation was superior to the conventional approach in terms of decreasing anxiety and enhancing and maintaining undergraduate nursing students' self-efficacy, satisfaction, and confidence.

The current study used a design of experiments to evaluate the potential synergistic effects of three Moroccan bee products (honey (H), propolis (P), and bee pollen (BP)) on the free radical inhibition and antibacterial activity against clinical strains of Staphylococcus aureus and Escherichia coli. The phytochemical contents of these three bee products were first evaluated using HPLC‐DAD with 20 identified compounds (9 in both H and P extracts and 13 in BP extract). The P extract had the highest phytochemical content, with high levels of flavanone pinocembrin, flavanol catechin, lignan pinoresinol, and simple phenolics (p‐coumaric and gallic acids). Then, the optimized mixtures were determined using an augmented simplex‐centroid design. The optimized formulations (H33%:P43%:BP24%) and (H21%:P47%:BP32%) presented the optimal total phenolic content and DPPH‐IC50 with 226.88 mgGAE/g and 10.64 µg/mL, respectively, whereas the formulations (H26%:P52%:BP22%) and (H35%:P40%:BP25%) showed the optimal antimicrobial activity against S. aureus (MICS.aureus equal to 4.34 µg/mL) and E. coli (MICE.coli equal to 5.70 µg/mL), respectively. The predicted responses from these mixture proportions were also experimentally validated. Compared to the single free radical activity and antibacterial effect of each isolated bee product, these optimized formulations demonstrated an increased biological activity, and the determination of the fractional inhibitory concentrations revealed a synergistic effect between these products. This study emphasizes the interest in optimized bee product mixtures for practical applications beyond the pharmaceutical and food industries. Their potential can be extended to nutraceuticals, cosmeceuticals, animal health, environmental sustainability, and advanced biomedical research, offering holistic solutions for diverse challenges across various sectors. Exploring these applications further can unlock new avenues for innovation and sustainable development.

As the population ages, the number of elderly patients admitted to the ICU continues to rise. The physiological changes associated with ageing represent a challenge for the management of this often-fragile population at high cognitive risk. An epidemiologic and evolution profile in our Moroccan context is necessary to improve survival and its quality in post-intensive care in our elders. This is a retrospective analytic study including all patients over 65 years of age admitted to the A4 polyvalent intensive care unit of the Hassan II University Hospital in Fez, from January 2017 to December 2021, excluding patients initially admitted for COVID-19 infection. The epidemiology, stay, management and outcome data were collected and analyzed.

Post-traumatic Perthes syndrome in adults is a rare manifestation. It poses a management problem and treatment is based on aggressive and directed management of the cardiopulmonary systems associated with rapid recognition and treatment of progressive lesions. The result differs depending on the duration, mechanism and severity of the compression, which justifies extreme caution in the approach to these patients. We report the observation of a rare case in a patient, with a history of DALY under treatment and hypertension poorly monitored under treatment, admitted to intensive care for Perthes syndrome resulting from serious thoraco-abdominal trauma following to a fall from a crane and whose clinical evolution was satisfactory. The objective is to emphasize the beneficial effects of early treatment of this rare syndrome in adults.

Introduction: Myasthenia crisis (MC) occurs in 15 % to 20 % of myasthenia gravis (MG) patients. How to prevent post-operative myasthenic crisis (POMC) is of great importance to the treatment of post-surgery MG patients. Methods: Retrospective study including myasthenia patients who underwent thymectomy and were admitted to our unit from January 2013 to December 2019. Variables analyzed were age, gender, history of MC, duration of disease, diagnostic parameters, preoperative functional muscle and Leventhal scores, Ossermann classification, patient comorbidities, treatment, and outcomes. Results: Thirty patients were included in this study. The mean age was 36.86 years. The sex ratio M/F was 0.30. Twenty percent of the patients had a history of MC. Bulbar symptoms were present in 50 % of cases. Anti-acetylcholine receptor antibodies were positive in 93 % of cases. The functional muscle score varied between 60 and 100 points with a mean of 83.63 points. The mean vital capacity was 3.302 liters. The Leventhal score was greater than 10 in five patients. Curarization was necessary in 25 patients and monitored in four cases. Surgical approach was median sternotomy in 86.67 % of cases and mean surgery duration was 159.83 minutes. The univariate analysis identified 5 variables significantly (p < 0.05) associated with the occurrence of POMC: Leventhal score > 10, weak functional muscle score, low vital capacity, prolonged duration of surgery, and prolonged length of ICU stay. Conclusion: Leventhal score > 10, weak functional muscle score, low vital capacity and prolonged surgery duration were independent risk factors for POMC.

Abstract Propolis and honey possess antioxidant, hypoglycemic, and antiproteinuric effects. The study aimed to explore the effect of propolis, honey, and their combination against D-glucose-induced hyperglycemia, acute kidney injury, liver injury, dyslipidemia, and changes in the oxidants and antioxidants in renal, hepatic, and pancreatic tissues. The chemical analysis and antioxidant content of propolis and honey were studied. The inhibitory effect of propolis and honey on alpha-amylase and alpha-glucosidase activity was studied. The study included five groups of rats, four groups treated with D-glucose and one group untreated. The D-glucose treated group (diabetic group) was divided into 1-4 groups. In addition to D-glucose, groups 2,3, and 4 were treated with propolis, honey, and a combination of propolis and honey respectively. Blood glucose levels, liver and renal function tests, urine protein and electrolytes, oxidant and antioxidant parameters, and histopathological changes in hepatic, renal, and pancreatic tissues were studied. Treatment with D-glucose continued for seven weeks, and with other interventions for the following 3 weeks. Propolis has a higher level of total protein and antioxidant activity than honey while honey contains higher carbohydrate levels. Honey has a higher alpha-amylase and glucosidase inhibitory activity than propolis. D-glucose caused a significant elevation of blood glucose, insulin, HOMA, blood urea, creatinine, lipid parameters, liver enzymes, and urine protein level. It significantly increases MDA and decreases antioxidant parameters in pancreatic, hepatic, and renal tissues. D-glucose caused histopathological changes in hepatic, renal, and pancreatic tissues. Propolis, honey, and their combination significantly ameliorated these changes. Propolis, honey, or their combination treated hyperglycemia, acute kidney injury, proteinuria, liver injury, and dyslipidemia, induced by D-glucose, most likely, by antioxidant activity and alpha-amylase and alpha-glucosidase inhibitory activity.