Objective: To evaluate the effect of combined suspl SD-Ag and SD-Ag-Zn-Azone cream on the wound healing in extensively burned patients.Methods: 174 burned patients admitted from January 2008 to December 2010,with burn size exceeding 35% TBSA,were randomly allocated into two groups:combined suspl SD-Ag and SD-Ag-Zn-Azone cream group was applied in 98 patients;while in other 76 patients povidone-iodine was used as control.Results: There was no significant difference between the two groups in mean age,burn size,and treatment.Wound infections,days of antibiotics administration,times of grafting,healing times and degree of scar hyperplasia were remarkably reduced in combined suspl SD-Ag and SD-Ag-Zn-Azone cream group.Conclusion: Combination of SD-Ag Suspension with SD-Ag-Zn-Azone Cream in wound healing of extensively burned patients can significantly increase resistance to infection compared with Iodophor,which is suitable for topical use in the self-healing of extensively burned patients.