1. A patient acquired 2 gonococcical infections in an interval of 5 months from 2 different partners. Treatment with chloromycetin failed but with the use of Penbritin the patient was cured. 2. The fact that both infections were not cured by chloromycetin suggests to us not only to consider resisting germs but what happens in the organism of the patient with the chloromycetin he has taken.

The effect of the oral contraceptives Noracyclin 22, Anovlar 21, Eugynon, Provera, and progesterone on longitudinal growth, width (acanthosis), pigmentation, and sebaceous glands of guinea pig teats were recorded. Treatment for 21 days consisted of 1/4 or 1/40 of a tablet orally; controls received .05 mcg hormoestrol (p,p-dioxydiphenylhexane), and another untreated control group was included. All drugs elongated guinea pig teats, measured by silhouette, and caused spreading (acanthosis). All of those containing estrogen induced hyperpigmentation of the aureolae, hormoestrol being the most potent. Hypertrophy of sebaceous glands developed after hormoestrol, Noracyclin, Eugynon in 1/40 tablet dose only, Provera and progesterone, but not Eugynon 1/4 tablet or Anovlar in either dose. The results on pigmentation were deemed clinically interesting with repsect to cholasma.

Les glandes sébacées au niveau de la tétine du cobaye augmentent sous l'influence d'oestrogènes.