Objective：Thoracoscopic pulmonary nodule resection can cause stress reaction, which is not conducive to the rehabilitation of patients. This paper explores the effect of nursing intervention based on the concept of rapid rehabilitation surgery on this situation. Methods: A total of 100 patients receiving thoracoscopic pulmonary nodule resection in our hospital during the same period（December 2019-December 2020）were selected as the subjects of this study. They were equally divided by random number table method. The reference group was given routine nursing intervention. The study group was given nursing intervention under the guidance of the concept of rapid rehabilitation surgery. The stress response indexes, rehabilitation effect and complications of the two groups were compared. Results: The postoperative heart rate index of the study group was higher than that of the reference group, while the C-reactive protein ( CRP ), interleukin-6 ( IL-6 ) and tumor necrosis factor-α ( TNF-α ) indexes were lower than those of the reference group ; the time of hospitalization, tracheal tube placement and thoracic drainage tube placement in the study group were shorter than those in the reference group, and the World Health Organization Quality of Life Scale-Brief ( WHOQOL-BREF ) score was higher than that in the reference group. The total probability of postoperative complications in the study group was lower than that in the reference group, and the difference was statistically significant ( P < 0.05 ). Conclusion: After thoracoscopic pulmonary nodule resection, nursing intervention based on the concept of rapid rehabilitation surgery can effectively alleviate the postoperative stress response of patients and strengthen the postoperative rehabilitation effect of patients, which has application significance.

目的:综合评价新生儿的出生质量,并进一步分析新生儿出生质量的影响因素,为卫生保健部门有效开展妇幼卫生工作提供理论依据.方法:随机选取到潍坊市4家不同级别的医院分娩或就诊的新生儿为调查对象.自行设计调查表,由妇幼专业人员采用面对面访谈的形式获取资料.应用均数、标准差及构成比等指标对新生儿出生质量进行描述,用四格表x2、R×C列表的x2检验分析可能的影响因素.结果:460例新生儿的各项形态学指标均在正常值范围内；小于胎龄儿、适于胎龄儿和大于胎龄儿分别占9.78％、86.52％、3.70％.新生儿出生质量与新生儿基本特征、母亲因素及家族史三方面有关.影响新生儿出生质量的因素包括分娩方式、宫内生长发育情况、母亲异常孕产史、妊娠合并症或并发症、是否患病或感染病毒5个因素.结论:针对性开展妇幼保健工作有利于提高新生儿的出生质量.

objective: To detect the expression and clinical significance of HIF-1α factor protein in endometrial carcinoma.Methods: 1.Using immunohistochemical staining method to detect the expression of HIF-1α protein in 72 cases of endometrial carcinoma tissue;2 Using labeled with colloidal gold immunoelectron microscopy methods to detect the expression of HIF-1α protein in the ultrastructure of endometrial cancinoma.Results:1.Immunohistochemical staining results show: in the 72 clinical cases of endometrial cancer tissue,39 cases of HIF-1expression was positive,the positive rate was 54.2%(39 /72);2.The results of labeled with colloidal gold immunoelectron microscopy show: the black circular HIF-1α colloidal gold particles exist in endometrial cancer cells endoplasmic reticulum and nuclear envelope,occasionally in the nucleus.Conclusion: Immunohistochemical and immunoelectron microscopy revealed: The expression of HIF-1α in the endometrial cancer tissue,suggesting that HIF-1α can be the new molecular target in endometrial cancer treated.

Objective:To evaluate the birth quality of neonates comprehensively,further analyze the effect factors of birth quality of neonates,provide a theoretical basis for health care departments to carry out maternal and child health works.Methods:The neonates who were born in four hospitals at different levels in Weifang city were selected randomly as study objects.A self-designed questionnaire was used to obtain data in a way of face-to-face interview conducted by maternal and child health workers.The indexes including mean,standard deviation,and constituent ratio were used to describe the birth quality of neonates,χ2 test was used to analyze the probable effect factors.Results:The morphological indexes of 460 neonates were in normal range;the proportions of small for gestational age infants,appropriate for gestational age infants,and large for gestational age infants accounted for 9.78%,86.52%,and 3.70%,respectively.The birth quality of neonates was related to general characteristics of neonates,maternal factor,and family history.The effect factors of birth quality of neonates included delivery modes,intrauterine growth and development,abnormal pregnant history of mothers,pregnant complications,falling ill and viral infection or not.Conclusion:Targeted work on maternal and child health should be carried out to improve the birth quality of neonates.

[Objective]To evaluate the birth quality of neonates and find the related influencing factors of the pregnancy,in order to provide evidence for carrying out effective measures for the maternity and child care.[Methods]Interview wea carried outandomly among the children who were born or received treatment in the following four hospitals,Weifang People's Hospital,Affiliated Hospital of Weifang Medical College,Maternity and Child Care Centers of Weifang City and Kuiwen District.[Results]The morphology indicators,height,head size,bust and BPD of the 460 neonates were all within the normal range;the clinical Agpar score higher than 7 were more than 95%;the proportion of birth weight 2.5 kg,2.5-4.0 kg,4.0 kg was 9.67%,86.59% and 3.74% respectively.The proportion of the normal birth weight,pregnancy live in the countryside,urban and city was 59.41%,90.32%,90.18%(P0.01),the cultural level was 80.95%,89.27%,90.24%(P0.05)respectively,the income level were 80.52%,96.55%,91.93%,84.00%(P0.01);with or without complications during the pregnancy was 65.71% and 88.45%(P0.01);with or without virus infection was 77.78% and 88.71%(P0.01);have or not have abnormal history was 76.79% and 87.80%(P0.05) respectively.[Conclusion]The height,head size,bust and BPD of the neonates are all in the normal range,part of them have lower birth weight.Living in the countryside,having complications during the pregnancy are the major reasons of the lower birth weight.

目的观察比较在人工流产术前分别口服和阴道放置米索前列醇用于软化宫颈的临床效果及安全性。方法将200例妊娠45～70天,要求行人工流产术的妇女随机分成两组,试验组100例用米索前列醇0.2mg于人工流产术前4～6h置于阴道后穹隆;对照组100例于手术前4～6小时口服米索前列醇0.2mg。观察两组病例手术时宫颈软化程度、宫口大小、出血量、子宫收缩情况、人工流产综合征的发生率。结果两组妇女宫颈软化程度、子宫收缩情况、出血量、人工流产综合征的发生率均有显著性差异(P<0.05)。结论人工流产术前阴道后穹隆放置米索前列醇,能软化宫颈、扩张宫颈,其方法简便、安全,能有效减轻妇女人工流产时的痛苦,预防人工流产并发症的发生。

目的 检测先兆流产患者和正常妊娠妇女羊水甲胎蛋白(AFP)的含量及胎盘增殖细胞核抗原(PCNA)的表达,探讨AFP,PCNA与先兆流产发生的关系.方法 2008年10月～2009年12月,我院32例先兆流产患者为研究组,32例正常妊娠妇女为对照组.用电化学发光法检测各组羊水AFP含量,免疫组织化学SP法检测胎盘组织PCNA的表达.结果 正常妊娠组及先兆流产组羊水AFP分别为(8356±607)μg/L,(7024±498)μg/L,两组之间比较差异有显著性(P<0.01).正常妊娠组及先兆流产组PCNA分别为(56.49±2.17)%,(48.96±1.43)%,两组比较差异有显著性(P<0.01).两组中胎盘PCNA增殖指数与同组羊水AFP显著相关(P均<0.01).结论 先兆流产的发生可能与AFP和PCNA的表达水平异常降低有关.

Objective To study the relationship between alpha-fetoprotein (AFP),proliferation cell nuclear antigen (PCNA) in amniotic fluid and spontaneous abortion through detecting the level of AFP and PCNA in spontaneous abortion patients and normal pregnancy women. Methods sixty-four spontaneous abortion patients were collected as study group,who was further divided into 2 subgroups corresponding to threatened abortion with 32 patients and missed abortion with 32 patients. The other 32 cases of normal pregnancy were as control group. The level of AFP in amniotic fluid was determined with chemiluminescence immunoassay. The expression of PCNA in placenta tissue was examined SP immune-histochemistry technique. Results The level of amniotic fluid AFP was(8 356±607)μg/L in normal pregnancy group,(7 024±498) μg/L in threatened abortion group,(5 638±533)μg/L in missed abortion group respectively. There were significant differences among three groups (P0.05). The positive rate of PCNA expression was(56.49±2.17)% in normal pregnancy group,(48.96±1.43)% in threatened abortion group,(39.53±1.74)% in missed abortion group recpectively. There were significant differences among three groups (P0.05). Proliferation index(PI) of PCNA was closely related to level of amniotic fluid AFP in every group (P0.05). Conclusion The results showed that low expression of AFP and PCNA may have relationship with spontaneous abortion.

Objective To probe into an effective mathematical model for fitting the prevalence of birth defect among the perinatal infants, so as to provide the theoretical evidence for the department of preventive measures. Methods Based on the national birth defect surveillance data between 2001 and 2006, 3 kinds of mathematical models (Linear model, Power model and Quadratic model) were used to fit the trend of prevalence of birth detect. The models were assessed by comparing the indexes of fitness and residues of the models. Results The Quadratic model was more suitable than the other models. The Quadratic function was: Y=92.8+12.018X-0.551X2. Conclusion The Quadratic model was an effective model in fitting the prevalence of birth defect in Chian from 2001 to 2006.

目的:探讨湿润烧伤膏外敷预防化疗性静脉炎的疗效。方法:将130例化疗患者随机分为观察组和对照组各65例,观察组采用距穿刺点0.5 cm上沿血管走向长10 cm、宽5 cm区域内皮肤涂湿润烧伤膏的方法,3次/d,输液结束后局部冷敷4h;对照组仅给予局部冷敷4h。观察1周后两组静脉炎的发生率。结果:观察组静脉炎发生率为9.2%,对照组静脉炎发生率为49.2%,两组比较有极显著性差异(P<0.01)。结论:湿润烧伤膏外敷预防化疗药物引起静脉炎效果明显优于单纯局部冷敷法。

近来,我们收治1例妊娠合并植入性胎盘患者,经积极治疗与精心护理,效果满意.现将护理体会报告如下. 1 病历资料 患者女,33岁,门诊以妊娠38周、重度子痫前期收入院.

2006年1月～6月,我们将度冷丁与非那根联合应用于1348例人工流产术中,取得满意效果.现报告如下.

2004年8月～2005年3月,我们对静脉化疗致静脉炎49例患者给予马铃薯片贴敷,效果满意.现报告如下.

浅静脉留置针具有减少血管损伤、利于定时给药和抢救等优点[1],已作为临床输液治疗的主要工具,封管是延长静脉留置针留置时间的重要环节,为降低堵管率,延长留置时间,我们对封管方法进行了研究.现报告如下.

众所周知,化疗药物对血管刺激性大,损害严重,外渗至外周组织可引起坏死,即使在确保静脉点滴畅通的情况下,大部分患者由于反复静脉输注化疗药物,引起血管红、肿、疼痛,血管硬化或萎缩,色素沉着等.我科自2002年11月开始应用红花酒湿敷血管,取得满意疗效.现将护理体会介绍如下.

乳腺癌不仅影响患者本身,而且包括患者配偶,易产生抑郁、焦虑、恐惧等负面情绪,致使生活质量下降.他们随着妻子病情的发展而变化,得出诊断时,他们感到无助,治疗期间忧虑加重,治疗后心理需求仍未满足.