BackgroundCongenital absence of the right coronary artery (RCA) is an extremely rare coronary anomaly with a very low incidence in the general population. The prevalence of complete atrioventricular (AV) block also appears to be low. No previous reports have documented the coexistence of congenital absence of the RCA and complete AV block in the same patient.Case summariesCase 1 was a 52-year-old man with no significant past medical history who experienced syncope. The initial ECG revealed complete AV block with a non-specific ST-T segment. Coronary angiography showed mild, non-obstructive atherosclerosis in the dominant left circumflex artery (LCx), which continued along the anatomical course of the RCA. The patient underwent a dual-chamber pacemaker implantation for complete AV block. Case 2 was a 79-year-old man with a history of hypertension and coronary heart disease who presented with gradually worsening fatigue lasting 6 h. ECG showed complete AV block with a non-specific ST-T segment. Coronary angiography revealed an abnormal origin of the RCA arising from the distal portion of a dominant LCx, which retrogradely followed the course of a normal RCA to the base of the heart. The patient also underwent a dual-chamber pacemaker implantation for complete AV block.ConclusionThese two cases represent the first reported instances of complete AV block coexisting with congenital absence of the RCA, where the LCx supplied the territory of the RCA without evidence of myocardial infarction.

BACKGROUND:In recent years, the impact of diet and lifestyle on coronary heart disease (CHD) has garnered significant attention. Caffeine, a common dietary component, and its metabolites may influence cardiovascular health. OBJECTIVE:This study aimed to investigate the association between urinary levels of caffeine and its metabolites and the incidence of CHD as well as to assess how these associations vary across different population groups. METHODS:Data from the NHANES database (2009-2014) were analyzed using multivariable logistic regression models and smooth curve fitting techniques. Participants were categorized into a control group (n = 5,005) and a CHD group (n = 222) based on CHD status. Urinary levels of caffeine and its metabolites were measured and recorded. Multivariable logistic regression was used to evaluate the association between urinary caffeine/metabolite levels and CHD incidence, while smooth curve fitting was employed to explore potential nonlinear relationships. A significance level of 5% was used to determine statistical significance. RESULTS:Higher urinary paraxanthine levels were associated with a lower risk of CHD. In contrast, elevated urinary caffeine levels were positively associated with CHD incidence among Mexican Americans, an association not observed in other racial/ethnic groups. CONCLUSION:Lower urinary paraxanthine levels may reflect a reduced risk of CHD, while higher urinary caffeine levels could indicate an increased CHD risk in specific populations.

Resumo Fundamento: Nos últimos anos, a influência da alimentação e do estilo de vida sobre a doença arterial coronariana (DAC) tem despertado crescente interesse. A cafeína, um componente alimentar amplamente consumido, e seus metabólitos podem exercer efeitos sobre a saúde cardiovascular. Objetivo: Investigar a associação entre os níveis urinários de cafeína e de seus metabólitos com a ocorrência de DAC, bem como avaliar se essas associações variam entre diferentes subgrupos populacionais. Métodos: Foram analisados dados do banco NHANES (2009-2014) por meio de modelos de regressão logística multivariada e técnicas de suavização por curvas. Os participantes foram categorizados em grupo controle (n = 5.005) e grupo com DAC (n = 222), conforme a presença ou ausência da doença. Os níveis urinários de cafeína e de seus metabólitos foram quantificados. A regressão logística multivariada foi empregada para avaliar a associação entre os níveis urinários dessas substâncias e a incidência de DAC, e a análise de curvas suavizadas permitiu explorar possíveis relações não lineares. O nível de significância adotado foi de 5%. Resultados: Níveis mais elevados de paraxantina urinária estiveram associados a menor risco de DAC. Por outro lado, concentrações mais altas de cafeína urinária apresentaram associação positiva com a incidência de DAC entre indivíduos mexicano-americanos, associação esta não observada em outros grupos raciais/étnicos. Conclusão: Concentrações urinárias reduzidas de paraxantina podem indicar menor risco de DAC, enquanto níveis elevados de cafeína urinária podem refletir risco aumentado em populações específicas.

Background: NHHR (non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio) is a new lipid parameter used to assess the risk of cardiovascular disease. However, the association between NHHR and the risk of depression has not been studied before. Methods: We conducted a cross-sectional study using datasets from the National Health and Nutrition Examination Survey (NHANES) 2005-2016. The PHQ-9 questionnaire was used to evaluate depression. A weighted multivariable logistic regression model and a restricted cubic spline (RCS) model were applied to investigate the association between NHHR and depression risk. Additionally, subgroup and sensitivity analyses were conducted to test the robustness of the results. Results: In the total population, compared with the lowest reference group of NHHR, participants in the fourth quartile had a significantly increased risk of depression after full adjustments (OR: 1.61, 95%CI: 1.05-2.49). A linear dose-response relationship existed between NHHR and depression risk (P non-linearity = 0.264). The association remained significant in several subgroup analyses. Limitations: The cross-sectional design and use of self-reported scales. Conclusion: NHHR was significantly associated with a higher risk of depression in U.S. adults. Additional research on NHHR would help in depression prevention and treatment.

Heart failure (HF) is a syndrome of symptoms and signs caused by cardiac insufficiency and have become a serious global health problem. The aim of this study is to clarify the role and mechanism failure of MIR17HG. We established the in vitro HF model by using H2O2-treated AC-16 and HCM cells, and the reactive oxygen species (ROS) level and natriuretic peptide precursor B (NPPB) expression were also detected. The RNA expression of MIR17HG, miR-153-3p, SIRT1, and NPPB were detected by quantitative reverse transcription PCR while the SIRT1 and NPPB expression were detected by western blot. The binding relationship among MIR17HG, miR-153-3p, and SIRT1 were assessed by dual-luciferase reporter assay and RNA binding protein immunoprecipitation assay. Then, MIR17HG and SIRT1 were overexpressed by lentivirus transfection, and the influence of MIR17HG and SIRT1 on H2O2-induced apoptosis mediated by p53 were evaluated. The results show that MIR17HG and SIRT1 were significantly downregulated, while miR-153-3p was significantly upregulated in HF model. Overexpression of MIR17HG reduced miR-153-3p and alleviated HF, while knockdown of SIRT1 weakened the effects of MIR17HG, suggesting that SIRT1 was the direct target of MIR17HG/miR-153-3p axis. MIR17HG is significantly downregulated in HF model. Our research shows that MIR17HG protects cardiomyocytes from ROS-induced damage via the MIR17HG/miR-153-3p/SIRT1 axis, suggesting that MIR17HG and SIRT1 are potential therapeutic targets in HF.

Abstract Background Glyphosate-based herbicides (GBHs) are used extensively around the world and have become the leading agrochemicals. However, study about the association between glyphosate exposure and diabetes is scarce. This study used four years of NHANES data (2013–2016) to further investigate the association. Methods A total of 2,806 participants were enrolled in this cross-sectional study. The baseline information and urine glyphosate levels in diabetic and non-diabetic groups were compared. We also divided urine glyphosate levels into tertiles. Three models were developed using weighted logistic regression. Further subgroup analyses based on categorical variables were also conducted. Results Urine glyphosate levels were 0.35ng/ml in people with diabetes and 0.44ng/ml in participants without diabetes (P < 0.05). Regardless of adjustment, the highest glyphosate level in the tertile3 group was significantly linked with an elevated risk of diabetes (OR 1.595, 95% CI 1.016–2.504, P = 0.043) compared to the tertile1 group. Subgroup analyses suggested that the associations were constant in participants who were male, older age (60–100), had a college degree, income ratio = 5, BMI > 30, and smoking. Conclusions This study provides new evidence that glyphosate exposure was associated with a higher risk of diabetes in the American general adult population.

BackgroundAlthough observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.MethodsWe conducted a two-sample Mendelian randomization (MR) study to analyze the causal relationship between TIA and CAD using data from the FinnGen genome-wide association study. Analysis was performed using the inverse-variance weighted (IVW) method. The robustness of the results was evaluated using MR-Egger regression, the weighted median, MR pleiotropy residual sum, and outlier (MR-PRESSO) and multivariable MR analysis.ResultsResults from IVW random-effect model showed that TIA was associated with an increased risk of coronary artery atherosclerosis (OR 1.17, 95% CI 1.06–1.28, P = 0.002), ischemic heart disease (OR 1.15, 95% CI 1.04–1.27, P = 0.007), and myocardial infarction (OR1.15, 95% CI 1.02–1.29, P = 0.025). In addition, heterogeneity and horizontal pleiotropy were observed in the ischemic heart disease results, while the sensitivity analysis revealed no evidence of horizontal pleiotropy in other outcomes.ConclusionsThis MR study demonstrated a potential causal relationship between TIA and CAD. Further research should be conducted to investigate the mechanism underlying the association.

BackgroundObservational studies have reported the association between fatigue and coronary artery disease (CAD), but the causal association between fatigue and CAD is unclear.MethodWe conducted a bidirectional Mendelian randomization (MR) study using publicly available genome-wide association studies (GWAS) data. The inverse-variance weighted (IVW) method was used as the primary analysis. We performed three complementary methods, including weighted median, MR-Egger regression, and MR pleiotropy residual sum and outlier (MR-PRESSO) to evaluate the sensitivity and horizontal pleiotropy of the results.ResultSelf-reported fatigue had a causal effect on coronary artery atherosclerosis (CAA) (OR 1.047, 95%CI 1.033–1.062), myocardial infarction (MI) (OR 1.027 95%CI 1.014–1.039) and coronary heart disease (CHD) (OR 1.037, 95%CI 1.021–1.053). We did not find a significant reverse causality between self-reported fatigue and CAD. Given the heterogeneity revealed by MR-Egger regression, we employed the IVW random effect model. For the examination of fatigue on CHD and the reverse analysis of CAA, and MI on fatigue, the MR-PRESSO test found horizontal pleiotropy. No significant outliers were found.ConclusionThe MR analysis reveals a causal relationship between self-reported fatigue and CAD. The results should be interpreted with caution due to horizontal pleiotropy.

Background:Heart failure (HF) is a complex and multifactorial syndrome caused by impaired heart function. The high morbidity and mortality of HF cause a heavy burden of illness worldwide. Non-thyroidal illness syndrome (NTIS) refers to aberrant serum thyroid parameters in patients without past thyroid disease. Observational studies have indicated that NTIS is associated with a higher risk of all-cause mortality in HF. This meta-analysis aimed to investigate the association between NTIS and HF prognosis. Methods:Medline, Embase, Web of Science, and the Cochrane database were searched for any studies reporting an association between NTIS and HF prognosis from inception to 1 July 2022. A meta-analysis was then performed. The quality of studies was assessed using the Newcastle-Ottawa Scale. The heterogeneity of the results was assessed with I2 and Cochran's Q statistics. Sensitivity analysis and publication bias analysis were also conducted. Results:A total of 626 studies were retrieved, and 18 studies were finally included in the meta-analysis. The results showed that NTIS in HF patients was significantly associated with an increased risk of all-cause mortality and major cardiovascular events (MACE), but not with in-hospital mortality. The stability of the data was validated by the sensitivity analysis. There was no indication of a publication bias in the pooled results for all-cause mortality and MACE. Conclusions:This meta-analysis showed that NTIS was associated with a worse outcome in HF patients. However, the association between NTIS and in-hospital mortality of HF patients requires further investigation.

In patients receiving surgery, increased blood pressure variability may contribute to the onset of acute kidney injury (AKI). However, the extent and significance of blood pressure variability in patients undergoing aortic dissection surgery have yet to be determined. The authors analyzed all patients operated for aortic dissection at Peking University Shenzhen Hospital from January 1, 2011 to December 31, 2021. Preoperative blood pressure variability was expressed as standard deviation, coefficient of variation (CV), and range. The primary outcome was postoperative AKI. After multivariate analysis, systolic blood pressure variability was found to be independently associated with AKI after aortic dissection surgery. The odds ratios and 95% confidence intervals for standard deviation, CV, and systolic blood pressure range were 1.232 (1.011–1.500), 1.451 (1.058–1.991), and 1.138 (0.986–1.288) for postoperative AKI, respectively. However, there was no significant relationship between diastolic blood pressure variability and AKI after aortic dissection surgery. Finally, in patients undergoing surgery for aortic dissection, the variability of systolic blood pressure is actually an important factor in the development of AKI.

This study attempted to identify exosomal circular RNAs (circRNAs) as diagnostic and prognostic biomarkers for patients with ST-segment elevation myocardial infarction (STEMI). The differentially expressed exosomal circRNAs (DEECs) were screened from microarray dataset (GSE160717 and GSE197137) and RNA-Seq dataset (GSE208194), and the expression levels of DEECs in patients with STEMI were validated using reverse transcription and quantitative real-time PCR. The diagnostic value of DEECs was assessed using receiver operating characteristic curves. The major adverse cardiovascular event (MACE)-free 1-year survival rate was evaluated using the Kaplan-Meier method, and the factors affecting prognosis were determined using Cox regression model analysis. Results showed that four DEECs were screened including exo-circ-0001490, exo-circ-0020887, exo-circ-0009590, and exo-circ-0055440, and only upregulated exo-circ-0020887 and exo-circ-0009590 expression was validated in patients with STEMI. The exo-circ-0020887 and exo-circ-0009590 expression was positively correlated with hs-CRP, LDL-C, cTnI, and CK-MB. The exo-circ-0020887 and exo-circ-0009590 showed good diagnostic efficacy to distinguish STEMI patients from healthy controls (area under the curves: 0.85 and 0.80). STEMI patients with high levels of exo-circ-0020887 and exo-circ-0009590 had lower MACE-free 1-year survival rate, and exo-circ-0020887 and exo-circ-0009590 expression was independent risk factors for adverse prognosis. In summary, upregulation of plasma exo-circ-0020887 and exo-circ-0009590 might act as potential biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in patients with STEMI.

BACKGROUND:The effect of antecedent hypertension on mortality after acute coronary syndromes (ACS) in the percutaneous coronary intervention era is unclear. Therefore, this meta-analysis aimed to assess the effect of antecedent hypertension on short-term and long-term mortality after ACS in the coronary intervention era.METHODS:PubMed, Medline, EMBASE, and the Cochrane library were systematically searched up to July 2023. Ten studies with a total of 64,989 of patients met the inclusion criteria. The outcomes of interest were all-cause in-hospital mortality and long-term all-cause mortality.RESULTS:No significant difference was observed in in-hospital mortality between the antecedent hypertension and non-antecedent hypertension groups in the ACS patients (pooled OR 1.07; 95% CI 0.79-1.45; I2=82%), which was the same as the ST elevation myocardial infarction group (pooled OR 1.01; 95% CI 0.73-1.39; I2=66%). However, the result was statistically significant for non-ST elevation myocardial infarction patients (pooled OR 0.67; 95% CI 0.55-0.82; p=0.0001; I2=0%). Antecedent hypertension was related to increased long-term mortality in patients with ACS (pooled OR 1.28; 95% CI 1.16-1.40; p=0.0001; I2=0%), which was the same as the ST elevation myocardial infarction subgroup.CONCLUSION:In the percutaneous coronary intervention era, antecedent hypertension is associated with higher long-term mortality in ACS patients. This meta-analysis found no significant difference in in-hospital mortality between the hypertension and non-hypertension groups. However, antecedent hypertension may be a protective factor related to in-hospital mortality for non-ST elevation myocardial infarction patients.

Background Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by exocrine and extra-glandular symptoms. The literature indicates that SS is an independent risk factor for atherosclerosis (AS); however, its pathophysiological mechanism remains undetermined. This investigation aimed to elucidate the crosstalk genes and pathways influencing the pathophysiology of SS and AS via bioinformatic analysis of microarray data. Methods Microarray datasets of SS (GSE40611) and AS (GSE28829) were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were acquired using R software’s “limma” packages, and the functions of common DEGs were determined using Gene Ontology and Kyoto Encyclopedia analyses. The protein–protein interaction (PPI) was established using the STRING database. The hub genes were assessed via cytoHubba plug-in and validated by external validation datasets (GSE84844 for SS; GSE43292 for AS). Gene set enrichment analysis (GSEA) and immune infiltration of hub genes were also conducted. Results Eight 8 hub genes were identified using the intersection of four topological algorithms in the PPI network. Four genes (CTSS, IRF8, CYBB, and PTPRC) were then verified as important cross-talk genes between AS and SS with an area under the curve (AUC) ≥0.7. Furthermore, the immune infiltration analysis revealed that lymphocytes and macrophages are essentially linked with the pathogenesis of AS and SS. Moreover, the shared genes were enriched in multiple metabolisms and autoimmune disease-related pathways, as evidenced by GSEA analyses. Conclusion This is the first study to explore the common mechanism between SS and AS. Four key genes, including CTSS, CYBB, IRF8, and PTPRC, were associated with the pathogenesis of SS and AS. These hub genes and their correlation with immune cells could be a potential diagnostic and therapeutic target.

BackgroundThe 5-year outcomes and predictors of atrial fibrillation (AF) recurrence following cryoballoon (CB) ablation in Chinese population remain scarce. Our aim was to report 5-year outcomes and predictors of AF recurrence following a single CB ablation procedure in a Chinese population.MethodsFrom December 2013 to August 2016, we included 256 consecutive patients (mean age: 58 ± 10.9 years old; female: 41.0%) with paroxysmal or persistent AF successfully underwent first-generation CB ablation at Fuwai hospital in this prospective study. All patients were followed at least 5 years or when there was recurrent AF. Independent predictors of AF recurrence were determined by Cox proportional hazards regression analysis.ResultsThe 5-year success rate after pulmonary vein isolation (PVI) by a single procedure was 59.4%. The recurrence rate was the highest (14.5%) within the first year after the index procedure, and then stabilized. Patients with paroxysmal AF had a higher incidence of freedom from AF recurrence than patients with persistent AF (63.2% vs. 36.4%, log-rank P < 0.01). The overall incidence of complications related to CB ablation was 7.8%. Phrenic nerve injury (PNI) was the most common complication, with an incidence of 3.5%, and patients with PNI were recovered within the 1-year follow-up. Only persistent AF (HR 1.72, 95%CI 1.028–2.854, P < 0.05) was significantly and independently associated with an increased risk of AF recurrence after adjusting for other factors.ConclusionPulmonary vein isolation using CB ablation was safe and effective with an acceptable complication and 5-year success rate in a Chinese population with AF, and persistent AF was the independent predictor for 5-year AF recurrence after a single CB ablation procedure.

目的从超声、生化、临床方面探讨沙库巴曲缬沙坦对射血分数降低心力衰竭（HFr EF）患者心功能改善的短期疗效。方法选择2018年6月～2019年9月在我院首诊为HFr EF的患者为研究对象,共20例,年龄51.4±9.923岁,规律服用血管紧张素转化酶抑制剂依那普利3月后换用沙库巴曲缬沙坦继续治疗3月。自身前后对比,分别比较患者确诊时、依那普利治疗3月时和换用沙库巴曲缬沙坦治疗3月后N末端脑钠肽前体、经胸超声心动图测定左室射血分数、6 min步行实验和纽约心功能分级。结果沙库巴曲缬沙坦治疗3月后患者左室射血分数的增幅大于依那普利治疗3月后对比于确诊时的增幅（P＜0.05）,沙库巴曲缬沙坦治疗3月后患者N末端脑钠肽前体的降幅大于依那普利治疗3月后对比于确诊时的降幅（P＜0.05）;同时患者使用2类药物后6 min步行实验、纽约心功能分级均有改善,差异有统计学意义（P＜0.05）,且沙库巴曲缬沙坦改善程度大于依那普利。结论沙库巴曲缬沙坦对射血分数降低心力衰竭患者心功能改善方面的短期疗效（3月）优于依那普利。

Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which results in cardiac hypertrophy and subsequent heart failure. Chronic inflammation in the diabetic heart results in loss of cardiomyocytes and subsequentially cardiac dysfunction. Accumulated evidence implicated pyroptosis as a vital contributor to the hyperglycemia-induced cardiac inflammatory response. Exendin-4, a GLP analog, promotes survival of cardiomyocytes in cardiovascular diseases, including diabetic cardiomyopathy. However, the role of Exendin-4 in cardiac pyroptosis remains to be elucidated. Our study revealed that Exendin-4 treatment protected against heart remolding and dysfunction and attenuated cardiac inflammation in high-fat diet-fed rats. The activity of caspase-1 and production of pyroptotic cytokines were significantly inhibited by Exendin-4 treatment in the diabetic heart and in high glucose-treated cardiomyocytes as well. In an effort to understand the signaling mechanisms underlying the antipyroptotic property of Exendin-4, we found that blockade of AMPK, an oxidative stress sensor, activity diminished the antipyroptotic property of Exendin-4. Phosphorylation of AMPK resulted in degeneration of TXNIP that promoted the activation of the NLRP3 inflammasome. Exendin-4 treatment decreased the protein level of TXNIP. Moreover, RNA silencing of TXNIP mimicked the antipyroptotic actions of Exendin-4. These findings promoted us to propose a new signaling pathway mediating cardioprotective effect of Exendin-4 under hyperglycemic conditions: Exendin-4 → ROS↓ → pAMPK↑ → TXNIP↓ → caspase-1↓ → IL-1β and IL-18↓ → pyroptosis↓. In general, our study identified Exendin-4 as a pyroptotic inhibitor protecting against hyperglycemia-induced cardiomyocyte pyroptosis via the AMPK-TXNIP pathway.

目的 探讨快速康复治疗理念在老年股骨颈骨折患者行人工髋关节置换围术期中的应用效果.方法 将138例老年股骨颈骨折患者按随机数字表法分为实验组和对照组,每组69例,均予以围术期传统模式治疗,实验组在此基础上予以围手术期快速康复治疗,观察3个月.采用Harris髋关节功能评分量表评定髋关节功能状况,生活质量综合评定问卷评定生活质量,疼痛视觉模拟评分法评定疼痛状况,自拟康复满意度调查问卷评定患者的住院康复满意度,统计并发症发生率及住院时间.结果 治疗后两组Harris髋关节功能评分量表、生活质量综合评定问卷评分均较治疗前显著升高,且实验组显著高于对照组(P<0.01);术后各时点实验组疼痛程度缓解显著优于对照组(P<0.01),并发症发生率显著低于对照组(P<0.01),康复满意度显著高于对照组(P<0.01),住院时间显著短于对照组(P<0.01).结论 老年股骨颈骨折行人工髋关节置换患者围术期予以快速康复治疗,能显著改善髋关节功能及生活质量,降低并发症发生率,缩短住院时间,提高康复满意度.

Objective To investigate the clinical significance of tricuspid annular plane systolic excursion (TAPSE) in patients with rheumatic mitral stenosis and regurgitation.Methods We prospectively studied the consecutive patients who were diagnosed as rheumatic mitral stenosis and regurgitation in the Fourth Hospital of Harbin Medical University between January 1,2014 and December 31,2015.No patients had been performed heart surgery ever.The biochemical markers,6-minute walking distance test and echocardiography were measured.Clinical data was obtained by clinical visits or telephone interviews.The end point date was taken as the occurrence date of endpoint events or a censor date of 10 June,2016.The primary endpoint events:rehospitalized for heart failure;secondary endpoint events:death or cardiac surgery.Results We enrolled 74 rheumatic mitral stenosis and regurgitation patients,including 9 males and 65 females.Of which 53 cases of patients had atrial fibrillation.TAPSE had good relation with serum BNP level and 6 minutes walking distance.The cut point of TAPSE was 13.5mm which was selected by receiver operating characteristic analysis (area under the curve 0.721,P =0.002).The patients with TAPSE ＜ 13.5mm had higher plasma BNP levels and poor 6-minute walk distance.By Kaplan-Meier survival curves,the survival of the subjects with TAPSE ＜ 13.5mm was significantly poor than those with TAPSE ≥ 13.5mm (P =0.005).Conclusion TAPSE is a powerful variable to reflect heart function and predict the survival of re-hospitalization in patients with rheumatic mitral stenosis and regurgitation.

Objective: To determine the features of supraventricular tachycardia (SVT) by examining cases from two main medical centers in the Heilongjiang province of northeastern China. Methods: A total of 1677 consecutive SVT patients diagnosed by electrocardiography at the Second and Fourth Affiliated Hospitals of Harbin Medical University between January 2009 and January 2012 were included in the study. Results: The SVT healing rate was 96%. Electrophysiology confirmed 550 patients with atrioventricular nodal re-entrant tachycardia (AVNRT, 33%) and 1076 patients with atrioventricular re-entrant tachycardia (AVRT, 64%). The patients underwent subsequent radiofrequency catheter ablation (RFCA). The RFCA success rate was 98.9% and 99.1% in the AVNRT and AVRT groups, respectively. AVRT patients were younger than AVNRT patients (41.6 +/- 15.7 years vs. 46.9 +/- 14.7 years). Women with AVNRT had a higher morbidity rate than men (61% vs. 39%), while men with AVRT had a higher morbidity rate than women (55% vs. 45%). Of AVRT and AVNRT patients, 98% and 97.3% were of Han nationality, respectively, which was not statistically significant compared with the local Han population. Conclusion: Nearly two-thirds of the residents in northeastern of China with SVT had AVRT. The morbidity rates for different types of SVT differed statistically with respect to age and gender. The majority of patients with SVT (96%) can be cured by RFCA.

Background The polyphenol resveratrol (Rev) has been reported to exhibit cardioprotective effects, such as inhibition of TAC (transverse aortic constriction) or isoprenaline (ISO)‐induced hypertrophy. Micro RNA ‐155 (miR‐155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of miR‐155 on cardiac hypertrophy, focusing on the role of breast cancer type 1 susceptibility protein ( BRCA 1). Methods and Results We demonstrated that Rev alleviated severity of hypertrophic myocardium in a mice model of cardiac hypertrophy by TAC treatment. Down‐regulation of miR‐155 was observed in pressure overload– or ISO ‐induced hypertrophic cardiomyoctyes. Interestingly, administration of Rev substantially attenuated miR‐155 level in cardiomyocytes. In agreement with its miR‐155 reducing effect, Rev relieved cardiac hypertrophy and restored cardiac function by activation of BRCA 1 in cardiomyoctyes. Our results further revealed that forkhead box O3a (FoxO3a) was a miR‐155 target in the heart. And miR‐155 directly repressed FoxO3a, whose expression was mitigated in miR‐155 agomir and mimic treatment in vivo and in vitro. Conclusions We conclude that BRCA 1 inactivation can increase expression of miR‐155, contributing to cardiac hypertrophy. And Rev produces their beneficial effects partially by down‐regulating miR‐155 expression, which might be a novel strategy for treatment of cardiac hypertrophy.