Neuronal activity drives parvalbumin-expressing interneuron maturation in the mouse cortex via its effects on the transcriptional cofactor PGC1α.

In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippocampus-dependent memory deficits.

A study in mice identifies formin 2 as a regulator of axon regeneration and a potential target for promoting nerve repair after peripheral nerve injury.

A study finds that microglia depletion has no effect on experience-dependent maturation of visual cortex circuitry in mice.

A study reveals a subpopulation of neuropeptide S-expressing neurons that regulates arousal and breathing.

A study identified two different blood biomarker profiles in people hospitalized for COVID-19 that predicted later cognitive deficits.

A study reports that in the mouse hippocampus, the induction of long-term potentiation is dependent on the structural functions of CaMKII and not its enzymatic activity.

The G-protein-coupled receptor GPR158 acts as a metabotropic glycine receptor in mice.

In a mouse model of tauopathy, neurodegeneration is dependent on the gut microbiota and is affected by apolipoprotein E isoform expression.

A new study examines thalamic innervation of cortical layer 2/3 pyramidal neurons and models how this thalamic connectivity affects visual responses in these cells.

new study shows that α-synuclein can interact with protein components of membraneless organelles involved in mRNA metabolism, and that such interactions may have relevance in Parkinson disease.

The modern human variant of the gene transketolase-like 1, but not the Neanderthal variant, promotes the production of basal radial glia during neocortical development.

new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.

In mice, infusions of young cerebrospinal fluid into the brains of aged animals promote oligodendrogenesis and improve memory.

study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.

A study shows that reducing tau acetylation protected neurons in a mouse model of traumatic brain injury.

A new study reports gene coexpression networks from across 12 major human brain regions and insights obtained from them into the biology and disorders of the brain.