Objective To investigate clinicopathological characteristics and differential diagnosis of malignant melanoma of the skin.Method The histopathological characteristics and clinical date of 29 cases were analyzed retrospectively.Results By microscopy,the cells type were composed of epithelioid,spindle,nevus-like,hylocyte and tumour giant.The tumour cells were arranged in nest-like,beam-like,adeniform fascicle-like,laciform,whirlpool and diffusion pattern.The immunohistochemically,the positive rates of S-100 protein,HMB45,Vimentin in 29 cases were 100%,93%,93%.Conclusion The histopathological structures and morphological characters of malignant melanoma are complex.The diagnosis relies mainly on histopathological and immunohistochemically findings.

Objective To investigate clinicopathological characteristics and differential diagnosis of primary thyroid lymphoma(PTL).Methods Two cases of PTL were studied and confirmed by histologic and immunohistochemical staining,and 199 cases with valid clinical information of PTL reported in literature by other authors in recent 10 years were reviewed.Results PTL occurred more often in old female,presenting as tumour in unilateral or bilateral thyroid,B-cell type were accounted for 94.5%(190/201) and of T-cell type,5.5% only(11/201).Conclusion PTL is a rare neoplasm.The diagnosis relies mainly on histopathological and immunohistochemical findings.

目的本文探讨9例神经母细胞瘤的临床病理特点,诊断及鉴别诊断要点.方法收集杨浦区中心医院1980年以来诊断为神经母细胞瘤病例临床资料及镜下表现.结果本文病例年龄最大14岁,最小2岁,5岁以下占62%,8岁以下占90%,9例中7例有转移.结论神经母细胞瘤是高发于儿童及幼儿的一种较少见的肿瘤,可发生于任何部位的一种胚胎性肿瘤,预后差.

Objective To investigate the expression of ER,PR,PCNA and C-CrbB-2 in uterine leiomyoma and its relationship with the growth of uterine leiomyoma.Method The positive rate of expression of ER,PR,PCNA and C-CrbB-2 in 50 cases of uterine leiomyoma was measured with immunochemistric method.The patients were divided into several groups according to the course of disease,symptom,diameter and number of uterine leiomyoma,menstrual cycle(proliferative phase and secretory phase).Results There were significant statistical differences between the positive rate of ER and PR expression and the diameter of uterine leiomyoma.The positive rate of ER expression in uterine leiomyoma during the proliferative phase was higher than that during the secretory phase(P0.05).The positive rate of PCNA and C-CrbB-2 expression was not associated with uterine leiomyoma.Conclusions The growth of uterine leiomyoma is closely related to the contents of ER and PR,but hardly related to the division and proliferation of cells,and not related to the expression of oncogene.