My major research focus areas have been in defining and characterising antigen and receptor targets for cancer therapy, signaling and metabolic pathways in cancer cells, antibody-based therapy and immune regulation of tumours, and molecular imaging of cancer. I have developed a program to translate our laboratory discoveries to use in the clinic, which has so far led to 10 novel antibodies and recombinant proteins progressing successfully through first-in-human, Phase I and II cancer trials. This program has delivered several key outcomes, including 21 patents and the licensing of seven discoveries to Pharma and Biotech. I have published over 330 peer-reviewed papers and 22 book chapters, principally in the areas of oncology and molecular imaging. My invited reviews in leading journals include Nature Reviews Cancer, Nature Reviews Clinical Oncology and Cancer Research. I am actively involved in the training and mentoring of young scientists and clinicians, and am currently supervising several doctoral students in addition to postdoctoral fellows and Nuclear Medicine trainees.