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I have several ongoing studies in my lab that deal with developmental cognitive disorders, studies that involve both children and rodent models. The goals of the animal studies are to determine the nature and underlying neural basis of the cognitive dysfunction, with implications for therapeutic intervention and for elucidating basic brain-cognition relationships. Four ongoing research projects concern, respectively, prenatal cocaine exposure, early postnatal lead exposure, and mouse models of Down syndrome and Fragile X syndrome. In the latter three projects we are also testing potential interventions. In the case of early lead exposure we are assessing the efficacy of the chelating agent, succimer, to lessen lead-induced cognitive deficits. In the research involving a mouse model of Down syndrome, we are planning to assess the ability to choline supplementation to improve cognitive functioning. In addition, I am just beginning two collaborative projects that focus on the cognitive effects of nutrient alterations during early development. One project is designed to assess the lasting effects of early iron supplementation on cognitive and affective development in children in Africa at high risk for anemia. The second project is designed to assess the effects of altered folate status -- due to both nutrition and genetics -- on cognitive functions dependent on neurogenesis. This project may inform recommendations about optimal folate intake to optimize early brain development and lessen aging-related cognitive decline.
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Progress in Neuro-Psychopharmacology and Biological Psychiatry (2024): 110949-110949
Neurotoxicology and teratology (2024): 107337-107337
biorxiv(2023)
bioRxiv : the preprint server for biology (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Frontiers in aging neuroscience (2021): 723046-723046
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