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个人简介
My research focuses on T cell antigen recognition and how it determines T cell responses. I use ultrasensitive two-dimensional (2D) methods to analyze T cell antigen recognition by measuring 2D kinetics of T cell receptor (TCR) and coreceptor (CD4/8) interacting with pMHC on live T cells at the single molecule/single cell level. I am currently working on a project looking at how diabetogenic CD8 T cells recognize beta-cell self-antigens and how 2D kinetics parameters correlate with type I diabetes. I am generally interested in the application of 2D methods to further our understanding of T cell antigen recognition in the broad context of viral infection, autoimmune diseases, and tumor immunology.
研究兴趣
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Nature Communicationsno. 1 (2023): 2616
JOURNAL OF IMMUNOLOGYno. 1 (2023)
Journal of Immunologyno. 1_Supplement (2023): 68.18-68.18
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Viva Jeanne Rase,Elizabeth M. Kolawole,Baoyu Liu,Cory M. Ayres, Jhordan Rogers,Khalid Salaita,Brian M. Baker,Brian D. Evavold
JOURNAL OF IMMUNOLOGYno. 1 (2023): 221.30-221.30
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Molecular & Cellular Biomechanicsno. 3 (2019): 211-223
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