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个人简介
From an entity perspective, research of the lab is centered around hematological malignancies, but also reaches out to GI tract cancers, melanoma and breast cancer. We have a long-standing interest in cellular failsafe mechanisms, i.e. programmed responses to severe cellular insults, as barriers to tumor manifestation, and, likewise, as effector principles of anticancer therapies. Complementing apoptosis and autophagy, cellular senescence is the failsafe program we are mostly interested in, because this terminal cell-cycle arrest condition has far-reaching ramifications in tumor biology, immunology, and treatment outcome. We investigate molecular mechanisms and translational implications of senescence in mouse models of lymphoma and melanoma, further exploit molecular findings in patient-reminiscent clinical trial-like “panomics” mouse studies, and probe their relevance in cross-species investigations of human tumor material with annotated clinical courses of the patients the material was derived from. More specifically, test platforms for primary patient-derived material include xenografts in mice, lymphoma-on-a-chip and other novel biotechnological approaches and will implment synthetic biology, too. Our interest in senescence spans fundamental cell biology ([epi-]genomics to systems biology), dynamics/reversibility and reprogramming/plasticity (e.g. senescence-associated stemness) over time, as well as host immune interdependencies.
研究兴趣
论文共 187 篇作者统计合作学者相似作者
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AMERICAN JOURNAL OF HEMATOLOGYno. 5 (2024): 1008-1011
JOURNAL OF EXPERIMENTAL MEDICINEno. 4 (2024)
Gabriel Rinnerthaler, Simon Gampenrieder,Angelika Pichler, Walter Herz,Andreas Petzer, Renate Pusch,Marija Balic,Christoph Suppan,Sonja Heibl, Lukas Scagnetti, Margit Sandholzer,Clemens Schmitt,
Cancer Researchno. 9_Supplement (2024): PO4-04
Simon Gampenrieder,Gabriel Rinnerthaler,Angelika Pichler, Walter Herz,Andreas Petzer, Clemens Dormann,Marija Balic,Christoph Suppan,Sonja Heibl, Lukas Scagnetti, Margit Sandholzer,Clemens Schmitt,
Cancer Researchno. 9_Supplement (2024): PO1-05
Gabriel Rinnerthaler,Daniel Egle,Rupert Bartsch,Clemens Schmitt,Andreas Petzer,Marija Balic,Edgar Petru, Ursula Denison,Christian F. Singer,Vesna Bjelic-Radisic, Simon Gampenrieder,Michael Knauer,
Cancer Researchno. 9_Supplement (2024): PO1-01
Yi Bei, Luca Bramé,Marieluise Kirchner,Raphaela Fritsche-Guenther,Severine Kunz, Animesh Bhattacharya, Mara-Camelia Rusu,Dennis Gürgen, Frank P.B. Dubios, Julia K.C. Köppke,Jutta Proba, Nadine Wittstruck,
crossref(2024)
Yi Bei,Luca Brame,Marieluise Kirchner,Raphaela Fritsche-Guenther,Severine Kunz, Animesh Bhattacharya, Mara-Camelia Rusu,Dennis Guergen, Frank P. B. Dubios, Julia K. C. Koeppke,Jutta Proba, Nadine Wittstruck,
CANCER DISCOVERYno. 3 (2024): 492-507
Heinz Ludwig, Thomas Melchardt, Ilvy Schweitzer,Siegfried Sormann, Martin Schreder,Johannes Andel,Bernd Hartmann, Niklas Zojer, Laurenz Schöffmann,Eberhard Gunsilius,Klaus Podar, Alexander Egle,
EJHaemno. 3 (2024): 494-504
S. Denker,Aitomi Bittner,Mareike Frick,Julia Kase,Joerg Hoffmann, Corinna Trenker,Ulrich Keller, Christian Bogner,Andreas Hüttmann,Jan Dürig,Martin Janz,Stephan Mathas,
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