基本信息
浏览量:1
职业迁徙
个人简介
The research program in my laboratory focuses on investigating and understanding the molecular and cellular mechanisms that govern the immune function. My laboratory has identified a novel development pathway that generates a CD4 T cell population bearing a unique innate effector function. These cells are called innate CD4 (iCD4) T cells. iCD4 T cells are similar to natural killer T cells that is another type of innate T cells. Innate T cells produce both Th1 and Th2 cytokines immediately after stimulation and exhibit a regulatory function. Development and function of innate T cells require adequate signaling delivered by pathways including mTOR, SLAM and Wnt. The different signaling requirements appear to contribute to distinct cell metabolism in innate T cells.
Innate T cells have high levels of reactive oxygen species (ROS) and thus susceptible to oxidative stress and undergo apoptosis. Modulation of ROS levels controls the cytokine expression suggesting a key role of ROS for the effector function. In contrast, innate T cells are resistant to ER stress. Innate T cells also exhibit a different glycolysis potential. Currently, we are working to discover how cell metabolism is regulated in innate T cells; how the difference in cell metabolism influences inflammatory responses; how mTOR and Wnt signaling pathways regulate the metabolic machinery and the effector function.
We are also studying human innate T cells to understand an inflammatory role caused by metabolic changes during immunopathogenesis.
Innate T cells have high levels of reactive oxygen species (ROS) and thus susceptible to oxidative stress and undergo apoptosis. Modulation of ROS levels controls the cytokine expression suggesting a key role of ROS for the effector function. In contrast, innate T cells are resistant to ER stress. Innate T cells also exhibit a different glycolysis potential. Currently, we are working to discover how cell metabolism is regulated in innate T cells; how the difference in cell metabolism influences inflammatory responses; how mTOR and Wnt signaling pathways regulate the metabolic machinery and the effector function.
We are also studying human innate T cells to understand an inflammatory role caused by metabolic changes during immunopathogenesis.
研究兴趣
论文共 94 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Ajay Kumar,Chenxian Ye, Afia Nkansah, Thomas Decoville,Garrett M Fogo,Peter Sajjakulnukit,Mack B Reynolds,Li Zhang,Osbourne Quaye, Young-Ah Seo,Thomas H Sanderson,Costas A Lyssiotis,
JOURNAL OF IMMUNOLOGYno. 1 (2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn