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Christopher Huang has contributed to understanding of the transduction and propagation of biological signaling events at the cellular and systems levels. This includes the initiation of striated muscle and osteoclast activity, mechanisms of cardiac arrhythmogenesis and cortical spreading depression in the central nervous system. This involved developing and integrating electrophysiological, spectrofluorimetric, confocal/electronmicroscope, magnetic resonance imaging (MRI), and mathematical modeling methods latterly in genetically modified murine systems. His current translational work on cardiac arrhythmogenesis similarly studies spreading physiological cellular and systems phenomena. It has separated the roles of after-depolarization phenomena, conduction velocity, restitution gradients, refractoriness and altered intracellular Ca2+homeostasis in ventricular arrhythmogenesis in hypokalaemic and genetically modified murine cardiac models for the Brugada, LQT3, LQT5, Scn3b-/-, catecholaminergic polymorphic ventricular tachycardic and metabolic syndromes. These arrhythmic exemplars are being used to develop a systematic classification of arrhythmogenic mechanisms in these conditions. It is separating the roles of after-depolarization and refractory phenomena, restitution gradients and altered intracellular Ca2+ homeostasis and conduction velocity in initiation of ventricular arrhythmogenesis potentially leading to sudden cardiac death. Having characterized fundamental arrhythmic mechanisms in experimental platforms recapitulating specific ion channel disorders, He is now proceeding to examine arrhythmic events in translational models for common human disorders such as metabolic disease and cardiac failure.
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Joshua A. Morris, Oliver J. Bardsley,Samantha C. Salvage,Antony P. Jackson,Hugh R. Matthews,Christopher L-H. Huang
FRONTIERS IN PHYSIOLOGY (2024): 1280151-1280151
Frontiers in physiology (2024): 1359560-1359560
FRONTIERS IN PHYSIOLOGY (2024): 1342761-1342761
Biologics : targets & therapy (2024): 115-127
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2024)
JOURNAL OF CELLULAR PHYSIOLOGY (2023)
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Journal of cellular physiologyno. 6 (2023): 1354-1367
Journal of Cellular Physiologyno. 6 (2023): 1354-1367
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Philosophical transactions of the Royal Society of London. Series B, Biological sciencesno. 1879 (2023): 20220160-20220160
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