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个人简介
Dr. Liu has a long-term interest in understanding of molecular basis of psychiatric diseases. His laboratory participated in one of the bipolar genetics research consortiums and discovered the rare copy number variant (CNV) burden in early-onset bipolar disorder. His lab is one of the leading research groups on genome-wide study of postmortem brain gene expression and DNA methylation, pioneered in study of gene expression regulatory network in human brain. He established the methylation quantitative trait loci (mQTLs) in human brain, indicating that DNA methylation of some sequences could be highly regulated by genetic variants. His lab currently focuses more on understanding genomic and epigenomic mechanisms in human brains for psychiatric disorders. His research has been supported by NIMH, NARSAD, and Brain Research Foundation. He has published more than 100 peer-reviewed papers and several book chapters, and been cited for more than 7,000 times, with H-index of 37. He has served as reviewer for dozens of journals and foundations including NIH. Dr. Liu’s major research focuses on using a comprehensive approach that is composed of genetics, bioinformatics, genomics, cellular and animal models to identify the molecular mechanisms of major psychiatric diseases, particularly bipolar disorder and schizophrenia. Constructing multidimensional regulatory network in human brains, and relating that to etiology and pathology of mental illness is the major mission of this lab.
Current major NIH-funded project is the psychENCODE project, investigating multi-dimensional biological features, networks in brains of bipolar disorder, schizophrenia and normal.
Current major NIH-funded project is the psychENCODE project, investigating multi-dimensional biological features, networks in brains of bipolar disorder, schizophrenia and normal.
研究兴趣
论文共 273 篇作者统计合作学者相似作者
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Chenglin Lyu,Roby Joehanes,Tianxiao Huan, Daniel Levy,Yi Li, Mengyao Wang,Xue Liu,Chunyu Liu,Jiantao Ma
BRITISH JOURNAL OF NUTRITIONpp.1-24, (2024)
Yu Chen,Sihan Liu,Zongyao Ren,Feiran Wang,Yi Jiang,Rujia Dai,Fangyuan Duan,Cong Han,Zhilin Ning,Yan Xia, Miao Li, Kai Yuan,
medRxiv : the preprint server for health sciences (2024)
Ashok Patowary,Pan Zhang, Connor Jops, Celine K Vuong,Xinzhou Ge,Kangcheng Hou,Minsoo Kim, Naihua Gong,Michael Margolis, Daniel Vo,Xusheng Wang,Chunyu Liu,
Science (New York, N.Y.)no. 6698 (2024): eadh7688-eadh7688
bioRxiv : the preprint server for biology (2024)
HUMAN REPRODUCTION OPENno. 1 (2024): hoae003-hoae003
Science advancesno. 21 (2024): eadh2588-eadh2588
Yan Xia,Cuihua Xia, Yi Jiang,Yu Chen,Jiaqi Zhou,Rujia Dai,Cong Han, Zhongzheng Mao,PsychENCODE Consortium,Chunyu Liu,Chao Chen,PsychENCODE Consortium
Science translational medicinepp.eadh9974-eadh9974, (2024)
The Cochrane database of systematic reviewsno. 6 (2024): CD015014-CD015014
Cindy Wen,Michael Margolis,Rujia Dai,Pan Zhang,Pawel F Przytycki, Daniel D Vo,Arjun Bhattacharya,Nana Matoba, Miao Tang,Chuan Jiao,Minsoo Kim,Ellen Tsai,
Science (New York, N.Y.)no. 6698 (2024): eadh0829-eadh0829
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