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Our goal is to understand the fundamental molecular motions and interactions that are responsible for cellular movement, to determine the molecular bases of muscle disorders, and to devise novel therapies based on these discoveries. We approach this multidisciplinary problem with a wide range of techniques — physiology, enzyme kinetics, molecular genetics, peptide synthesis, computer simulation — but our forte is site-directed spectroscopic probes.
After attaching probes (spin labels, fluorescent dyes, phosphorescent dyes, or isotopes) to selected muscle proteins in solution or in cells, we perform magnetic resonance or optical spectroscopy to directly detect the motions of the force-generating proteins, actin and myosin, or the membrane ion pumps and channels responsible for muscle excitation and relaxation. These same tools are then used to test the efficacy of gene or drug therapies designed to treat heart failure or muscular dystrophy.
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Levy M Treinen, Johnathan C Solberg,Robyn T Rebbeck, Marzenna Brinkmann,Kaja Berg, Jake A Schwarz,Andrew R Thompson,Courtney C Aldrich,David D Thomas,Jennifer J Thomas,Razvan L Cornea
Journal of immunological methods (2023): 113440-113440
David Thomas, Vijayvardhan Kamalumpundi, Amirtha Thampi,Kashelle Lockman, Mary B Carter,Navjyot Vidwan, Ann Broderick
Antimicrobial Stewardship & Healthcare Epidemiologyno. 1 (2023): e196-e196
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biorxiv(2023)
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