基本信息
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Career Trajectory
Bio
The group works in three areas: viral genomics pertaining to any virus family: herpesviruses, West Nile virus, SARS-CoV-2, cancers caused by Kaposi Sarcoma-associated herpesviruses, and the fundamental biology of exosomes.
We established the UNC Vironomics core (http://www.med.unc.edu/vironomics) to apply cutting-edge genomic technologies, such as next-generation sequencing to viral genomes and virus gene expression. This includes single-cell measurements, and it utilizes samples from clinical trials in the U.S., South Africa, and Malawi.
Approximately 1/4 of all human cancers are of viral origin or require viral infection as an essential cofactor. The main goal of our research is to understand cancers that are caused by Kaposi sarcoma-associated herpesvirus (KSHV). In the U.S., KS is seen in the context of HIV or in transplant patients. In Sub-Saharan Africa, KS is the most common cancer in males and is also seen in children. We have developed transgenic mice, which express the viral proteins and micro RNAs.
Exosomes are a new and exciting area of research in the lab. Exosomes are on 50-120 nm particles, which like viruses, carry proteins and miRNAs to neighboring cells and are intricately linked to viral pathogenesis.
Research Interests
Papers共 316 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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主题
期刊级别
合作者
合作机构
Lakshmi Rajdev,Chia-Ching Jackie Wang,Himanshu Joshi,Shelly Lensing,Jeannette Lee,Juan Carlos Ramos,Robert Baiocchi,Lee Ratner,Paul G. Rubinstein,Richard Ambinder,David Henry,Howard Streicher,Richard F. Little,Elizabeth Chiao,Dirk P. Dittmer,Mark H. Einstein,Ethel Cesarman,Ronald Mitsuyasu,Joseph A. Sparano
Cancerno. 6 (2024): 985-994
Cell host & microbe (2024)
BMC BIOINFORMATICSno. 1 (2023)
crossref(2023)
Carolina Caro-Vegas,Alice Peng,Angelica Juarez,Allison Silverstein,William Kamiyango,Jimmy Villiera,Casey L. Mcatee,Rizine Mzikamanda,Tamiwe Tomoka,Erin C. Peckham-Gregory,Razia Moorad,Carrie L. Kovarik,Liane R. Campbell,Parth S. Mehta,Peter N. Kazembe,Carl E. Allen,Michael E. Scheurer,Nmazuo W. Ozuah,Dirk P. Dittmer,Nader Kim El-Mallawany
JCI Insight (2023)
JOURNAL OF EXTRACELLULAR VESICLESno. 6 (2023)
crossref(2023)
crossref(2023)
Methods in molecular biology (Clifton, NJ) (2023): 45-55
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Author Statistics
#Papers: 314
#Citation: 12422
H-Index: 56
G-Index: 103
Sociability: 7
Diversity: 4
Activity: 75
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