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个人简介
The primary focus of her research is to understand the tug-of-war between the immune system and bacterial pathogens during infections. She is particularly intrigued by host-adapted enteric pathogens that have evolved to persist within hosts for long periods of time and spread to new hosts. She has discovered specific immune responses that help the host tolerate high levels of pathogen, referred to as “superspreaders”. She studies pathogen-microbiota interactions in the gut and has discovered that specific commensal bacteria-derived metabolites help defend against bacteria that cause food poisoning. In addition, her laboratory studies how immune cells recognize pathogenic bacteria that are residing within them. Her lab discovered that two innate immune pathways are sequentially linked and that this 2-tiered response is a host gauge of the “danger” level before commitment to host cell death.
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论文共 197 篇作者统计合作学者相似作者
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Alvin Han, Courtney Hudson-Paz,Beatriz G Robinson, Laren Becker,Amanda Jacobson,Julia A Kaltschmidt, Jennifer L Garrison,Ami S Bhatt,Denise M Monack
Lab animalpp.1-12, (2024)
Ruth Schade,Daniel S C Butler,Joy A McKenna, Blanda Di Luccia, Vida Shokoohi,Meagan Hamblin,Trung H M Pham,Denise M Monack
Scientific reportsno. 1 (2024): 12811-12811
Benjamin X Wang, Dmitry Leshchiner, Lijuan Luo, Miles Tuncel,Karsten Hokamp,Jay C D Hinton,Denise M Monack
Nature genetics (2024)
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2024): 120-120
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Journal of Immunologyno. 1 (2023): 82.06-82.06
Current opinion in immunology (2023): 102367-102367
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