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Today, my laboratory has two main foci of research. The first is the heterogeneity of the neuroinflammatory response in the Alzheimer’s disease brain and assessing how this heterogeneity contributes to the progression of the pathology and clinical symptoms of the disease. We use both human autopsy tissue and transgenic mouse models to assess this. We are also studying immune modulating therapies targeting the TREM2 microglial receptor in our animal models as potential therapies for Alzheimer’s disease. We have developed the hyperhomocysteinemia (HHcy) model of VCID. This is a model that generates grey matter microhemorrhages, neuroinflammation and cognitive impairment. The model of HHcy is generated by diet administration, which can therefore be administered to different genetic backgrounds or models.
研究兴趣
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ALZHEIMERS & DEMENTIAno. 2 (2024): 1374-1386
Brain communicationsno. 3 (2024): fcae157-fcae157
Dana M. Niedowicz,Jenna L. Gollihue,Erica M. Weekman, Panhavuth Phe,Donna M. Wilcock, Christopher M. Norris,Peter T. Nelson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISMno. 4 (2024): 595-610
Strokeno. 4 (2024): 801-811
Frontiers in aging neuroscience (2024): 1412006-1412006
Molecular Neurodegenerationno. 1 (2023): 1-3
Ahmed A Bahrani,Erin L Abner,Charles S DeCarli,Justin M Barber, Abigail C Sutton,Pauline Maillard, Francisco Sandoval,Konstantinos Arfanakis, Yung-Chuan Yang,Arnold M Evia,Julie A Schneider,Mohamad Habes,
Journal of Alzheimer's disease : JADno. 2 (2023): 683-693
Courtney M Kloske, Christopher J Barnum,Andre F Batista,Elizabeth M Bradshaw,Adam M Brickman,Guojun Bu,Jessica Dennison,Mary D Gearon,Alison M Goate,Christian Haass,Michael T Heneka,William T Hu,
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 6 (2023): 2677-2696
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