Eliot R. Spindel
教授
Division of Neuroscience
Oregon National Primate Research Center, Oregon Health & Science University;Knight Cancer Institute, School of Medicine, Oregon Health & Science University;Department of Behavioral Neuroscience, School of Medicine, Oregon Health & Science University;Department of Cell, Developmental and Cancer Biology, School of Medicine, Oregon Health & Science University
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Fetal lung, infant lung, mature lung and lung cancer are all direct targets of nicotine because of the high expression of nicotinic receptors in normal, developing and diseased lung. A major focus of the Spindel laboratory is to understand the role of nicotinic receptors in normal lung development and develop therapeutic approaches to block the effects of prenatal nicotine exposure on lung development. This is being pursued in clinical studies in conjunction with the OHSU pediatrics and maternal-fetal medicine departments, in studies in monkeys and in transgenic mice. Key to understanding the effects of maternal smoking during pregnancy on lung development is understanding the balance between the nicotine addiction that drives continued smoking and the direct effects of nicotine on the developing lung. The epigenetic mechanisms underlying how maternal smoking during pregnancy causes life-long changes in offspring lung function are also being investigated. Because so many of the effects of smoking during pregnancy are mediated by nicotine, the Spindel laboratory is also interested in potential harms of e-cigarette use during pregnancy on offspring respiratory health.
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论文共 212 篇作者统计合作学者相似作者
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Adam Crosland,Ava Mandelbaum,Bharti Garg,Sarena Hayer, Kimberly Ryan,Cindy McEvoy,Lyndsey Shorey-Kendrick,Eliot Spindel,Aaron B. Caughey,Jamie Lo
American Journal of Obstetrics and Gynecologyno. 1 (2024): S348-S349
Journal of Urologyno. Supplement 4 (2023)
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JOURNAL OF UROLOGY (2023): E3-E4
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Clinical Epigeneticsno. 1 (2023): 104-104
Pingfang Song, Harmanjatinder S. Sekhon,Xiao Wen Fu, Michelle Maier,Yibing Jia,Jie Duan, Becky J. Proskosil, Courtney Gravett,Jon Lindstrom, Gregory P. Mark, Saurabh Saha,Eliot R. Spindel
crossref(2023)
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