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个人简介
The research of Dr. Nelson is focused on the elucidating the endocrine and metabolic control of cancer pathophysiology. He is specifically interested in the molecular physiology behind how obesity and hypercholesterolemia contribute to cancer progression. His work has found that a metabolite of cholesterol 27-hydroxycholesterol, can bind to and activate the estrogen receptors, promoting breast tumor growth. 27-hydroxycholesterol was also found to increase breast cancer metastasis, a striking finding considering that the majority of breast cancer patients will eventually succumb to metastatic disease, not to the primary tumor. His laboratory is currently working on determining the mechanisms behind this observation and how other endocrine factors influence metastasis. The major goal is to develop novel lifestyle or therapeutic strategies to prevent and treat metastatic disease. This research is of incredible importance, given the current obesity crisis and that the majority of breast cancer patients will eventually relapse with metastatic disease
研究兴趣
论文共 177 篇作者统计合作学者相似作者
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Yu Wang, Bryan Duong,Natalia Krawczynska,Shruti V. Bendre, Claire P. Schane, Erin Weisser, Lara Kockaya, Yifan Fei,Anasuya Das Gupta, Hashni E. Vidana Gamage,Adam T. Nelczyk,Erik R. Nelson
Cancer Researchno. 6_Supplement (2024): 1409-1409
GUT MICROBESno. 1 (2024): 2295429-2295429
Cancer Researchno. 6_Supplement (2024): 1258-1258
Cancer Researchno. 6_Supplement (2024): 6000-6000
Journal of Biological Chemistryno. 3 (2024)
Shruti V. Bendre,Natalia Krawczynska, Shaunak Bhogale, Erin Weisser, Simon Han, Basel Hajyousif, Avni Singh, Rajendra K C,Yu Wang, Claire P. Schane,Adam T. Nelczyk, Anasuya DasGupta,
Cancer Researchno. 6_Supplement (2024): 174-174
Mahmoud A. Alfaqih,Erik R. Nelson, Wen Liu,Rachid Safi, Jeffery S. Jasper,Everardo Macias, Joseph Geradts,J. Will Thompson,Laura G. Dubois, Michael R. Freeman,Ching-yi Chang, Jen-Tsan Chi,
crossref(2023)
Andrea K Corbet,Emmanuel Bikorimana,Raya I Boyd,Doha Shokry, Kelly Kries,Ayush Gupta, Anneliese Paton,Zhengyang Sun,Zeeshan Fazal,Sarah J Freemantle,Erik R Nelson,Michael J Spinella,
Translational oncology (2023): 101676-101676
Mahmoud A. Alfaqih,Erik R. Nelson, Wen Liu,Rachid Safi,Jeffery S. Jasper,Everardo Macias, Joseph Geradts,J. Will Thompson,Laura G. Dubois, Michael R. Freeman,Ching-yi Chang, Jen-Tsan Chi,
crossref(2023)
Mahmoud A. Alfaqih,Erik R. Nelson, Wen Liu,Rachid Safi, Jeffery S. Jasper,Everardo Macias,Joseph Geradts,J. Will Thompson,Laura G. Dubois, Michael R. Freeman,Ching-yi Chang, Jen-Tsan Chi,
crossref(2023)
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