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Research Summary
Objectives include:
Elucidating the molecular mechanisms that are responsible for cardiac failure in diabetes.
Elucidating the molecular signals that coordinate the mitochondrial and metabolic adaptations to cardiac growth.
Elucidating the mechanisms by which insulin and growth factor signaling regulate cardiac mitochondrial function and the adaptation of the heart to stress.
Elucidating the role of mitochondrial dysfunction in the pathogenesis of insulin resistance, diabetes and its complications.
Our recent studies have underscored the importance of mitochondrial oxidative stress as a major mechanism leading to cardiac dysfunction in obesity and diabetes. Recent studies have focused on: (1) The contribution of excessive myocardial insulin signaling in the myocardium in accelerating left ventricular remodeling in the hypertrophied and failing heart. (2) The regulation of myocardial autophagy by insulin signaling. (3) The mechanisms by which myocardial lipid overload alters autophagy in cardiac muscle (4) The role of altered mitochondrial dynamics in the pathophysiology of cardiac dysfunction in obesity and insulin resistant states. (5) Mechanisms for increased thrombosis in obesity and insulin resistant states.
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Sarah H. Bjorkman,Alex Marti,Jayashree Jena, Luis Miguel García-Peña,Eric T. Weatherford,Kevin Kato,Jivan Koneru,Jason Chen, Ayushi Sood,Matthew J. Potthoff,Christopher M. Adams,E. Dale Abel,
Scientific Reportsno. 1 (2024): 1563-1563
Diabetesno. 2 (2024): 151-161
The EMBO journalno. 3 (2024): 362-390
Physiology (Bethesda, Md.) (2024)
IEEE transactions on nanobioscienceno. 1 (2024): 157-166
Cardiovascular research (2024)
IEEE TRANSACTIONS ON NANOBIOSCIENCEno. 1 (2024): 157-166
Natali Froese,Malgorzata Szaroszyk,Paolo Galuppo,Joseph R. Visker,Christopher Werlein,Mortimer Korf-Klingebiel,Dominik Berliner,Marc R. Reboll, Rana Hamouche, Simona Gegel, Yong Wang,Winfried Hofmann,
JOURNAL OF THE AMERICAN HEART ASSOCIATIONno. 3 (2024): e033553-e033553
Kit Neikirk,Zer Vue,Prasanna Katti, Ben I. Rodriguez, Salem Omer,Jianqiang Shao,Trace Christensen, Edgar Garza Lopez,Andrea G. Marshall,Caroline B. Palavicino‐Maggio, Jessica Ponce,Ahmad F. Alghanem,
Advanced Biologyno. 6 (2023)
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