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个人简介
Research Description: Mechanisms of activation and detoxication of chemical carcinogens and toxicants; characterization of enzymes involved in these processes Major areas of interest include the metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA. Several approaches are being used to understand the catalytic mechanisms of the human cytochrome P450 enzymes, including site-directed and random mutagenesis, kinetic analysis, isotope effects, and substrate-activity relationships. Work on halogenated hydrocarbons is done with trichloroethylene, ethylene dibromide, and methylene dihalides and the adducts they form. Glutathione transferase-mediated bioactivation is under investigation, as well as in the case of some bifunctional electrophiles. Studies on the polymerases involve the use of modified oligonucleotides, steady-state and pre-steady-state kinetics, and physical approaches such as x-ray diffraction. A major goal is to understand how carcinogen-DNA adducts cause polymerases to stall and misincorporate bases.
See website at www.toxicology.mc.vanderbilt.edu/CenterInvest/guengerich.
See website at www.toxicology.mc.vanderbilt.edu/CenterInvest/guengerich.
研究兴趣
论文共 991 篇作者统计合作学者相似作者
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Journal of biological chemistry/The Journal of biological chemistryno. 2 (2024): 105625-105625
International journal of molecular sciencesno. 16 (2024)
Archives of toxicology (2024)
Chemical research in toxicologyno. 5 (2024): 671-674
Journal of Biological Chemistryno. 1 (2024): 105495
Yasuhiro Tateishi,Stephany N Webb,Bian Li, Lu Liu,Kristie Lindsey Rose,Micheal Leser, Purvi Patel,F Peter Guengerich
The Journal of biological chemistryno. 3 (2024): 105688-105688
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作者统计
#Papers: 991
#Citation: 57239
H-Index: 119
G-Index: 201
Sociability: 8
Diversity: 0
Activity: 4
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