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As the king of tumor suppressors, p53 plays a central role in tumor prevention. p53 is the most frequently-mutated gene in human tumors; over 50% of all human tumors harbor p53 mutations, and over 80% of tumors have p53 dysfunction. As a transcription factor, p53 regulates a wide variety of cellular responses, including cell cycle arrest, apoptosis, senescence, metabolism, autophagy, ferroptosis and immune response, to exert its function in tumor suppression. Given its critical role in cancer, p53 has attracted tremendous studies and become an extremely attractive target for cancer therapy. One of our main research interests is to study the mechanism of p53 in tumor suppression and how it can be targeted for cancer therapy. We study new regulators and new regulation mechanisms for p53 and its signaling pathway, such as new E3 ubiquitin ligases, microRNAs and Sumoylation modification that regulate p53 and its signaling pathway. Furthermore, many tumor-associated mutant p53 proteins often gain new oncogenic activities in promoting tumorigenesis in addition to loss of wild-type p53 function in tumor suppression, which is defined as mutant p53 gain-of-function. We study the mechanism underlying the mutant p53 gain-of-function in tumorigenesis and how to target mutant p53 for cancer therapy.
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论文共 198 篇作者统计合作学者相似作者
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Xue Yang,Jianming Wang,Chun-Yuan Chang,Fan Zhou,Juan Liu,Huiting Xu,Maria Ibrahim, Maria Gomez,Grace L. Guo, Hao Liu,Wei-Xing Zong,Fredric E. Wondisford,
Nature Communicationsno. 1 (2024): 1-15
Nature Communicationsno. 1 (2024): 1-15
Zhihua Kang,Pan Fu,Hui Ma, Tao Li, Kevin Lu,Juan Liu, Vasudeva Ginjala,Peter Romanienko,Zhaohui Feng,Ming Guan,Shridar Ganesan,Bing Xia
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Cancer Researchno. 6_Supplement (2024): 432-432
The American journal of pathologyno. 5 (2024): 637-640
Zhaohui Feng,Wenwei Hu, Elisa de Stanchina, Angelika K. Teresky, Shengkan Jin,Scott Lowe,Arnold J. Levine
crossref(2023)
bioRxiv : the preprint server for biology (2023)
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Zhaohui Feng,Wenwei Hu, Elisa de Stanchina, Angelika K. Teresky, Shengkan Jin,Scott Lowe,Arnold J. Levine
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EMBO Reportsno. 9 (2023)
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