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职业迁徙
个人简介
After completing my PhD in biophysical protein chemistry at the University of Copenhagen (2005) I joined the NMR group of prof. Lewis E. Kay at the University of Toronto for postdoctoral training. The main focus of my postdoctoral research was development of NMR methodology to study protein dynamics and develop methods to characterise thermally excited and low populated states of proteins. These excited states often play important roles in ligand binding, molecular recognition, enzyme catalysis, and protein folding, however, they are ‘invisible’ to most of the traditional tools of structural biology. With our new methods we can now determine excited state structures by NMR relaxation dispersion experiment, so long as their lifetimes are between 0.5 and 10 ms and their population exceeds 0.5%. We applied our new methods to determine the structure and dynamics of protein folding intermediates, etc.
In October 2010 I joined the ISMB with a BBSRC David Phillips fellowship.
In October 2010 I joined the ISMB with a BBSRC David Phillips fellowship.
研究兴趣
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Journal of Magnetic Resonancepp.107699, (2024)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 4 (2024): 2319-2324
crossref(2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 41 (2023): e2310910120-e2310910120
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
STRUCTUREno. 11 (2023): 1360-1374
Zenodo (CERN European Organization for Nuclear Research) (2023)
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