基本信息
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Career Trajectory
Bio
邓宏魁,北京大学博雅讲席教授、长江学者特聘教授,北京大学干细胞研究中心主任,清华-北大生命科学联合中心高级研究员,国家杰出青年科学基金获得者,973项目和国家重点研发计划首席科学家。课题组长期以来致力于开发调控细胞命运的新方法和建立多潜能干细胞制备的全新底层技术,累计发表论文160余篇,被引用16,000余次,尤其在小分子化合物诱导细胞命运转变方面做出了一系列开拓性工作:1)首次实现完全使用小分子化合物逆转“发育时钟”,让小鼠体细胞重新获得多潜能性(Science, 2013),在后续的研究工作中揭示了化学重编程全新的分子机制(Cell, 2015; Cell Stem Cell, 2018),一系列成果开创了全新的体细胞重编程体系;2) 首次实现完全使用小分子化合物诱导人类体细胞转变为多潜能干细胞(hCiPS细胞)(Nature, 2022),是我国从源头上独创的新一代多潜能干细胞制备技术;3)利用小分子化合物建立了一种全新的具有全能性特征的干细胞(EPS细胞)(Cell, 2017),从小鼠2细胞胚胎建立了新型全能性干细胞(TPS细胞)(Cell Res, 2022);4)利用小分子化合物实现功能成熟细胞在体外的长期维持(Science, 2019),从多潜能干细胞诱导制备功能成熟的肝细胞,在急性肝衰猪模型上成功完成了人工肝治疗的动物实验;从多潜能干细胞高效分化制备功能成熟的胰岛细胞,在糖尿病小鼠和猴模型上验证了有效性和安全性(Nature Medicine, 2022);5)实现小分子化合物诱导小鼠体细胞成为功能性神经元(Cell Stem Cell, 2015),并实现了在成年小鼠大脑中将体细胞原位转变神经元的体内重编程(Cell Discov, 2021)。
Research Interests
Papers共 262 篇Author StatisticsCo-AuthorSimilar Experts
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Science China Life Sciencesno. 3 (2024): 529-542
Yingfeng Zhang, Yuanyuan He, Chenyi Dai, Zhengyang Zhou, Yudi Miao, Zixin Zhao, Qi Lei,Cheng Li,Chengyan Wang,Hongkui Deng
Cell reports methodsno. 9 (2024): 100843-100843
Huangfan Xie,Guangya Li, Yunxi Fu,Nan Jiang, Simeng Yi,Xi Kong,Jihang Shi,Shigang Yin,Jianhua Peng,Yong Jiang,Shichun Lu,Hongkui Deng,Bingqing Xie
Stem Cell Research & Therapyno. 1 (2024): 1-17
Zhilang Li, Lisha Ma,Zhaoya Gao, Xiya Wang, Xuan Che, Pengchong Zhang, Yixian Li, Qianjing Zhang, Tianxing Liu, Yuan Sun,Yun Bai,Hongkui Deng
Yun Lv, Ziyan Rao,Lulu Liu,Jun Jia,Chenyang Wu,Jun Xu,Yuanyuan Du,Yinan Liu,Bei Liu,Jihang Shi,Guangya Li,Dongyu Zhao,Hongkui Deng
CELL PROLIFERATIONno. 2 (2024): e13540-e13540
Huijuan Hua,Yaqi Wang, Xiaofeng Wang,Shusen Wang, Yunlu Zhou,Yinan Liu,Zhen Liang,Huixia Ren, Sufang Lu,Shuangshuang Wu, Yong Jiang,Yue Pu, Xiang Zheng,Chao Tang,Zhongyang Shen,Cheng Li,Yuanyuan Du,Hongkui Deng
Cell stem cell (2024)
Jingjing Zhao,Jiebin Dong,Changwen Deng, Qianjing Zhang,Shicheng Sun,Honggang Li,Yun Bai,Hongkui Deng
OncoImmunologyno. 1 (2023): 2265703-2265703
Wenjun Yang,Yaqi Wang,Yuanyuan Du, Jiyong Li,Minzhi Jia, Sheng Li,Ruimiao Ma,Cheng Li,Hongkui Deng,Ping Hu
Journal of cachexia, sarcopenia and muscleno. 2 (2023): 903-914
Qi Dong, Kailin Chen,Hongkui Deng, Hui‐Lan Rao,Huiqiang Huang,Yiji Liao,Xiaofei Sun,Suying Lü,Zhimin Yuan,Dan Xie, Qing-Qing Cai
openalex(2023)
Liang, Zhen,Sun, Dong,Lu, Shuaiyao, Lei, Zhengjun,Wang, Shusen,Luo, Zhifeng, Zhan, Jinqin,Wu, Shuangshuang, Jiang, Yong,Lu, Zhi,Sun, Shicheng, Shi, Yingying,Long, Haiting,Wei, Yanling,Yu, Wenhai, Wang, Zhihui,Yi, Liew Soon, Zhang, Yun, Sun, Wenyong, Fang, Xiaofeng,Li, Yanyan, Lu, Sufang, Lv, Jiayun,Sui, Weiguo,Shen, Zhongyang,Peng, Xiaozhong,Du, Yuanyuan,Deng, Hongkui
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Author Statistics
#Papers: 266
#Citation: 28896
H-Index: 69
G-Index: 169
Sociability: 7
Diversity: 3
Activity: 80
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