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He will be best known for his achievements in MRSA research including: development of a rapid PCR detection method for MRSA now used in Europe and the USA (1996), discovery of the first VISA Mu50 and hetero-VISA Mu30 (1997) and identification of SCCmec types I~III from healthcare-associated MRSA (HA-MRSA) and types IV, V from community-associated MRSA (CAMRSA) (1999~2004). He was the first to sequence S. aureus (N315, Mu50) (2001) and CA-MRSA MW2 (2002). He also proposed thickened cell wall and ‘peptidoglycan clogging’ as a mechanism for vancomycin resistance in VISA strains (2003~2007) and discovered of the origin of mecA gene in S. fleurettii (2010).
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FIRMAN SETIAWAN,TADASHI BABA,YUH MORIMOTO, YOSUKE NAKAGAWA, RYOTARO SHIMOGAMI,TERUO KIRIKAE,KEIICHI HIRAMATSU
Juntendo Medical Journalno. 2 (2022): 147-156
Scientific reportsno. 1 (2021): 5447-5447
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