Genome and epigenome editing
For nearly a decade, the lab has developed robust reagents and methods that enable targeted genome editing, including: zinc finger nucleases, tale nucleases, crispr/cas nucleases, and base editors.
We have shown the utility of these platforms for targeted epigenome editing, through histone modification and heterotopic activation to alter gene expression.
Together, we and our collaborators have created genome and epigenome edits with high efficiencies in zebrafish, plants or human somatic and pluripotent stem cells.
Keith's PRESENTATION at ASGCT 2023 summarizes the LAB's research achievements